Results 31 to 40 of about 412 (248)

Molecular Glue cc‐885 Inhibits VHL‐Deficient Clear Cell Renal Cell Carcinoma via ETS1 Degradation

Advanced Science, EarlyView.
VHL‐deficient kidney cancer lacks effective treatments. This study reveals that the molecular glue degrader cc‐885 hijacks the cellular recycling system to selectively destroy the oncogenic protein ETS1, effectively killing VHL‐mutant tumors. Combining CC‐885 with the approved drug belzutifan achieves powerful synergy, offering a promising new ...
Taowei Yang, Qihao Li, Kun Ye, Kezhi Liu, Mi Zhou, Minyu Chen, Lican Liao, Kangbo Huang, Zhu Wang, Qiong Deng, Jieyan Wang, Meiyu Jin, Xu Chen, Hui Liang, Jiaxing Zhang, Junhang Luo   +15 more
wiley   +1 more source

A Quantitative Lithium Inventory Framework for Anode‐Free Lithium Metal Batteries

Advanced Energy Materials, EarlyView.
A component‐resolved lithium inventory framework quantitatively tracks Li redistribution across the cell in anode‐free NMC622||Cu pouch cells throughout cycling. Three sequential degradation stages are identified: formation‐driven cathode Li depletion, midlife inactive Li0 accumulation, and late‐stage runaway SEI thickening. The cathode, as the sole Li
Wurigumula Bao, Alex Liu, Thomas S. Marchese, Yuanlong Bill Zheng, Weikang Li, Dhevathi Rajan Rajagopalan Kannan, Vallabha Rao Rikka, Vinay Premnath, Judith Jeevarajan, Ying Shirley Meng   +9 more
wiley   +1 more source

Accounting for Substitution: Improving Estimates of GHG Reductions From Cattle‐Based Product Demand Shifts

Applied Economic Perspectives and Policy, EarlyView.
ABSTRACT Estimates of reductions in greenhouse gas (GHG) emissions from lower demand for cattle‐based products must account for substitution effects. This study collected data through two surveys—one on ground beef and another on dairy milk—to evaluate substitution effects and potential GHG reductions.
Brandon R. McFadden, Sara Gardner Hedgecock, Lawton L. Nalley, Alvaro Durand‐Morat, Aaron Shew, Rodolfo M. Nayga Jr   +5 more
wiley   +1 more source

Do Tax Incentives for Farmland Leases Increase Farm Supply? Evidence From Iowa's Beginning Farmer Tax Credit

Applied Economic Perspectives and Policy, EarlyView.
ABSTRACT In recent decades, agriculture has become increasingly concentrated through horizontal mergers and acquisitions via corporate entities, and policy makers are concerned this will be exacerbated by the aging population of farm operators. To reduce market concentration in agriculture, many states have enacted policies to entice new prospective ...
Justin M. Ross, Wesley M. Zebrowski, Julia C. D. Valliant   +2 more
wiley   +1 more source

Acquiescence and Its Role in the Settlement of Island Disputes: “Silence May also Speak”, But to What Extent?

Chinese Journal of International Law, 2021
Abstract Acquiescence usually takes the form of silence or absence of protest in circumstances that reasonably call for objections. This notion has been frequently invoked by States in territorial cases, especially recent island disputes. Based on the latest international jurisprudence, this article will study whether, and to what extent,
openaire   +1 more source

A longitudinal study of the relationships between four differentially motivated forms of employee silence and burnout [PDF]

, 2019
Although previous research has established that employee silence can weaken organizational performance and development, less is known about potential detrimental effects of silence on individual employees, who may believe that they have plausible reasons
Weigelt, O., Knoll, M., Hall, R.
core   +1 more source

Organizational cynicism, silence, gossip, "onstage communication", "offstage communication"

, 2022
Three datasets: Study 1, Study2, Study 3 relate to the consequences of organizational cynicism, which are negative gossip about the supervisor and employee silence.
Adamska Krystyna
core   +1 more source

THE EFFECT OF TRANSFORMATIONAL AND TRANSACTIONAL LEADERSHIP ON ORGANİZATİONAL SILENCE [PDF]

, 2020
Çalışanlar fikir ve önerilerini özgür bir şekilde söyleyebildiklerinde ve seslerini duyurabildiklerinde daha etkili görev yapmaktadırlar. Çalışanların sessizliği örgütsel değişimin önünde engel olarak görülmektedir.
Özden AKIN, Akın, Özden
core   +1 more source

Analyzing individual rent price ratios in eastern German agricultural land markets: A GAMLSS approach

Agribusiness, EarlyView.
Abstract This study explores the rent price ratio in agricultural land markets, crucial for evaluating market efficiency, policy needs, and farmer decision‐making. Traditionally, the analyses faced challenges due to the absence of concurrent sale and rent data for the same land, potentially leading to biased results.
Marius Michels, Cord‐Friedrich von Hobe, Miryam Sarah Merk, Thomas Kneib, Oliver Musshoff   +4 more
wiley   +1 more source

How Does Cultural and Colonial Heritage Affect Optimal Branding Strategies? Evidence From the Rice Sector in Senegal

Agribusiness, EarlyView.
ABSTRACT Africa's cultural and colonial heritage has profoundly segmented rice markets. Whereas in ancient centers of rice domestication, consumers maintained preferences for local rice consistent with their cultural heritage, preferences have shifted toward imported Asian rice in coastal areas around seaports, due to prior exposure to colonial import ...
Kofi Britwum, Matty Demont
wiley   +1 more source