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Epigenetic Regulation Towards Acquired Drug Resistance in Cancer
2022Therapy resistance remains the most challenging obstacle in cancer treatment. Substantial efforts and evidences have accumulated over decades suggesting not only genetic but non-genomic mechanisms underlying this adaptation of tumor cells. Alterations in epigenome can have a fundamental effect on cellular functions and response to stresses like ...
Madhura, Ketkar, Shilpee, Dutt
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Intrinsic or acquired drug resistance and metastasis: Are they linked phenotypes?
Journal of Cellular Biochemistry, 1994AbstractEvidence is reviewed which suggests a linkage may exist between certain forms of de novo or acquired drug resistance and metastasis. This includes finding that expression of certain dominantly acting mutant oncogenes or tumor suppressor genes, e.g.
R S, Kerbel, H, Kobayashi, C H, Graham
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DRUG-RESISTANT PATHOGENS IN COMMUNITY- AND HOSPITAL-ACQUIRED PNEUMONIA
Clinics in Chest Medicine, 1999Antimicrobial resistance has been a problem since the early days of the antibiotic era, but in recent years, this resistance has increased in the hospital and is being recognized more in the community setting. Respiratory pathogens such as S. pneumoniae and H.
J T, Cross, G D, Campbell
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Drug-resistant Streptococcus pneumoniae in community-acquired pneumonia
Current Infectious Disease Reports, 2003The emergence of Streptococcus pneumoniae isolates resistant to not only penicillin, but to other antipneumococcal agents as well, has major public health implications. Drug-resistant S. pneumoniae are distributed worldwide, and resistance has become increasingly prevalent in the United States within the past decade.
Michael, Henry, Howard L., Leaf
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Primary antituberculosis drug resistance and acquired rifampicin resistance in Gujarat, India
Tubercle, 1988The prevalence of primary antituberculosis drug resistance in Gujarat, as studied between 1983 and 1986, was found to be significantly high, especially for isoniazid (13.9%) and streptomycin (7.4%). Primary rifampicin and pyrazinamide resistance were not detected in any strain. The prevalence of rifampicin resistance among treatment failure and relapse
S S, Trivedi, S G, Desai
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Risk factors for acquired drug-resistant tuberculosis
European Respiratory Journal, 2013According to WHO estimates Moldova leads among 27 countries with highest level of MDR-TB, with 27% in new cases and 51% in previously treated, causing 76% of TB-deaths. Patients with treatment failure have the highest rate of MDR. Aim risk factors study for acquired drugresistant-TB (DR-TB). Design Case-control study included 121 new pulmonary TB cases
Evelina Lesnic +2 more
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Acquired resistance to drugs: the loss of selectivity
1975A drug designer may build the highest degree of selectivity into his agents, only to see it lost through the development of resistance in his target organism. Drug resistance can arise in at least five distinct ways.
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Somatic Evolution of Acquired Drug Resistance in Cancer
2011Acquired drug resistance is a central problem in cancer medicine. The diverse molecular mechanisms of acquired drug resistance all arise through the same process of somatic (within-body) cellular evolution. Even targeted drugs are subject to this failure.
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Biofilm-Associated Multi-Drug Resistance in Hospital-Acquired Infections: A Review
Infection and Drug Resistance, 2022Azanaw Amare, Muluneh Assefa
exaly
Acquired drug resistance in tuberculosis in Harayana, India.
The Journal of the Association of Physicians of India, 2001Sputa of 200 treatment failure cases of pulmonary tuberculosis over a period of 1991-1995 were subjected to culture and sensitivity testing against commonly used anti-tuberculosis drugs. Out of 200 cases, 75% revealed resistance to one or more anti-TB drugs, resistance to isoniazid was observed in 72% cases, it was 49% for rifampicin, and 37% for ...
A K, Janmeja, B, Raj
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