Results 21 to 30 of about 22,878 (213)

Conformational restriction shapes the inhibition of a multidrug efflux adaptor protein

open access: yesNature Communications, 2023
Membrane efflux pumps play a major role in bacterial multidrug resistance. The tripartite multidrug efflux pump system from Escherichia coli, AcrAB-TolC, is a target for inhibition to lessen resistance development and restore antibiotic efficacy, with ...
Benjamin Russell Lewis   +11 more
doaj   +1 more source

The Efficiency Analysis of Pension Savings and Pension Reserves under the Management of Russian Non-State Pension Funds

open access: yesКорпоративные финансы, 2017
This research addresses the problem of pension savings and pension reserves management efficiency analysis of the whole Russian pension system and non-state pension funds.
Yury Nogin
doaj   +1 more source

Expression of the Fluoroquinolones Efflux Pump Genes acrA and mdfA in Urinary Escherichia coli Isolates [PDF]

open access: yesPolish Journal of Microbiology, 2017
Escherichia coli is one of the most frequent causes of urinary tract infections. Efflux system overexpression is reported to contribute to E. coli resistance to several antibiotics. Our aim in this study was to investigate the relation between antibiotic
Sarah M. Abdelhamid, Rania R. Abozahra
doaj   +1 more source

Defining the RND-binding residues of AcrA

open access: yesAccess Microbiology, 2020
The resistance-nodulation-division (RND) family of efflux pumps confer clinically relevant antibiotic resistance in Gram-negative bacteria, such as Salmonella enterica. RND pumps, including AcrB, are organized as tri-partite systems, consisting of an inner membrane RND pump, a periplasmic adaptor protein (PAP) and an outer membrane channel. Previously,
Ilyas Alav   +3 more
openaire   +1 more source

A bacterial glycoengineered antigen for improved serodiagnosis of porcine brucellosis [PDF]

open access: yes, 2016
Brucellosis is a highly zoonotic disease that affects animals and human beings. Brucella suis is the etiological agent of porcine brucellosis and one of the major human brucellosis pathogens.
Balzano, Rodrigo E.   +9 more
core   +1 more source

Welcome to Children — A New Open Access Journal Dedicated to Sharing Medical Research Relevant to Children’s Health

open access: yesChildren, 2013
I am very excited about the upcoming launch of Children, a journal dedicated to the streamlined yet scientifically rigorous electronic dissemination of peer-reviewed science related to childhood health and disease in developed and developing countries ...
Sari Acra
doaj   +1 more source

Regular Combinators for String Transformations [PDF]

open access: yes, 2014
We focus on (partial) functions that map input strings to a monoid such as the set of integers with addition and the set of output strings with concatenation.
Alur R.   +3 more
core   +2 more sources

A Novel Routing Algorithm for Power Line Communication over a Low-voltage Distribution Network in a Smart Grid

open access: yesEnergies, 2013
A novel artificial cobweb routing algorithm (ACRA) for routing the tree-type physical topology of a low-voltage distribution network in a smart grid is proposed and analyzed in this paper.
Dianguo Xu   +3 more
doaj   +1 more source

Membrane fusion proteins of type I secretion system and tripartite efflux pumps share a binding motif for TolC in gram-negative bacteria. [PDF]

open access: yesPLoS ONE, 2012
The Hly translocator complex of Escherichia coli catalyzes type I secretion of the toxin hemolysin A (HlyA). In this complex, HlyB is an inner membrane ABC (ATP Binding Cassette)-type transporter, TolC is an outer membrane channel protein, and HlyD is a ...
Minho Lee   +5 more
doaj   +1 more source

Detection of acrA, acrB, aac(6′)-Ib-cr, and qepA genes among clinical isolates of Escherichia coli and Klebsiella pneumoniae [PDF]

open access: yes, 2016
Background: The distribution of drug resistance among clinical isolates of Escherichia coli and Klebsiella pneumoniae has limited the therapeutic options. The aim of this study was to report the prevalence of quinolone resistance genes among E.
Bahramian, Aghil   +6 more
core   +1 more source

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