Unravelling the Pathotype, Biofilm, Virulome and Resistome Profile of MultiDrug-Resistant Bacteria Isolated From Cattle Faeces Using Whole Genome Sequence Analysis. [PDF]
Int J MicrobiolThe high mortality and morbidity resulting from diarrhoeal cases worldwide are associated with the increasing incidence of antimicrobial resistance (AMR) and represent a serious public health concern. Cattle are a major reservoir of AMR organisms, and faecal shedding may facilitate their transmission into the food chain.
Abolarinwa TO +9 more
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Integrons and Efflux Pump-Mediated Antibiotic Resistance in Multidrug-Resistant (MDR) Uropathogenic Escherichia coli. [PDF]
Biomed Res IntObjective Integrons facilitate the acquisition and expression of antibiotic resistance genes, with Classes 1 and 2 commonly found in clinical E. coli. The AcrAB–TolC efflux pump is a major RND system that expels diverse antimicrobial agents and contributes to resistance.
Gonbadi MA +4 more
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Conformational Flexibility in the Multidrug Efflux System Protein AcrA [PDF]
Structure, 2006 Intrinsic resistance to multiple drugs in many gram-negative bacterial pathogens is conferred by resistance nodulation cell division efflux pumps, which are composed of three essential components as typified by the extensively characterized Escherichia coli AcrA-AcrB-TolC system.
Helen Zgurskaya, Partho Ghosh
exaly +3 more sources
Molecular cloning and characterization of acrA and acrE genes of Escherichia coli [PDF]
Journal of Bacteriology, 1993 The DNA fragment containing the acrA locus of the Escherichia coli chromosome has been cloned by using a complementation test. The nucleotide sequence indicates the presence of two open reading frames (ORFs). Sequence analysis suggests that the first ORF encodes a 397-residue lipoprotein with a 24-amino-acid signal peptide at its N terminus.
John E Hearst, D N Cook, H Nikaido
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Surface Contamination by Multidrug-Resistant Gram-Negative Bacteria in a Healthcare Facility: Resistance Determinants and Biofilm-Associated Adhesion. [PDF]
Int J MicrobiolHospital surfaces represent a major reservoir of multidrug‐resistant Gram‐negative bacteria (MDR‐GNB), which contributes to healthcare‐associated infections. This study characterized the occurrence, resistance determinants, and biofilm‐forming behavior of MDR‐GNB isolated from hospital surfaces in a Moroccan regional hospital.
Dihmane A +6 more
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Development of a set of bacterial engineered glycoconjugates as novel serogroup-specific antigens for the serodiagnosis of Escherichia coli O26, O111, O103 and O45 infections associated to hemolytic uremic syndrome. [PDF]
Microb Cell FactHemolytic uremic syndrome associated to Shiga toxin-producing Escherichia coli infection (STEC-HUS) is a life-threatening condition characterized by microangiopathic hemolytic anemia, thrombocytopenia, and acute kidney failure. Among STEC, E.
Caillava AJ +9 more
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Microbiology SpectrumWhole-genome sequencing of a clinical tigecycline non-susceptible Klebsiella pneumoniae strain reveals a novel T188A mutation in AcrA, raising awareness on its role in tigecycline resistance.
Hai Xu, Mingyu Wang, Ling Li
exaly +3 more sources
Detection of AcrA and AcrB Efflux Pumps in Multidrug-Resistant Klebsiella pneumonia that Isolated from Wounds Infection Patients in Al-Diwaniyah Province [PDF]
Archives of Razi Institute, 2023 Many infections produced by multidrug-resistant (MDR) Klebsiella pneumoniae are the main cause of death and treatment restrictions worldwide. In K. pneumoniae, the efflux pump system is dangerous in drug resistance.
S Abid Fazaa ALmiyah
doaj +1 more source