Results 1 to 10 of about 4,300 (176)

Development of a set of bacterial engineered glycoconjugates as novel serogroup-specific antigens for the serodiagnosis of Escherichia coli O26, O111, O103 and O45 infections associated to hemolytic uremic syndrome [PDF]

Microbial Cell Factories
Hemolytic uremic syndrome associated to Shiga toxin-producing Escherichia coli infection (STEC-HUS) is a life-threatening condition characterized by microangiopathic hemolytic anemia, thrombocytopenia, and acute kidney failure. Among STEC, E.
Ana J. Caillava, Luciano J. Melli, Malena Landoni, Stella Maris Landivar, Isabel Chinen, Alicia S. Couto, Marta Rivas, Juan E. Ugalde, Diego J. Comerci, Andrés E. Ciocchini   +9 more
doaj   +2 more sources

A widespread single amino acid mutation in AcrA reduces tigecycline susceptibility in Klebsiella pneumoniae

Microbiology Spectrum
Whole-genome sequencing of a clinical tigecycline non-susceptible Klebsiella pneumoniae strain reveals a novel T188A mutation in AcrA, raising awareness on its role in tigecycline resistance.
Wenya Su, Mingyu Wang, Hai Xu
exaly   +3 more sources

Detection of AcrA and AcrB Efflux Pumps in Multidrug-Resistant Klebsiella pneumonia that Isolated from Wounds Infection Patients in Al-Diwaniyah Province [PDF]

Archives of Razi Institute, 2023
Many infections produced by multidrug-resistant (MDR) Klebsiella pneumoniae are the main cause of death and treatment restrictions worldwide. In K. pneumoniae, the efflux pump system is dangerous in drug resistance.
S Abid Fazaa ALmiyah
doaj   +1 more source

Unravelling the Pathotype, Biofilm, Virulome and Resistome Profile of MultiDrug-Resistant Bacteria Isolated From Cattle Faeces Using Whole Genome Sequence Analysis. [PDF]

Int J Microbiol
The high mortality and morbidity resulting from diarrhoeal cases worldwide are associated with the increasing incidence of antimicrobial resistance (AMR) and represent a serious public health concern. Cattle are a major reservoir of AMR organisms, and faecal shedding may facilitate their transmission into the food chain.
Abolarinwa TO, Ajose DJ, Oluwarinde BO, Ewunkem AJ, Montso PK, Engohang-Ndong J, Callaway TR, Fayemi OE, Aremu AO, Ateba CN.   +9 more
europepmc   +2 more sources

Integrons and Efflux Pump-Mediated Antibiotic Resistance in Multidrug-Resistant (MDR) Uropathogenic Escherichia coli. [PDF]

Biomed Res Int
Objective Integrons facilitate the acquisition and expression of antibiotic resistance genes, with Classes 1 and 2 commonly found in clinical E. coli. The AcrAB–TolC efflux pump is a major RND system that expels diverse antimicrobial agents and contributes to resistance.
Gonbadi MA, Dini Y, Mohammadi M, Pournajaf A, Halaji M.   +4 more
europepmc   +2 more sources

ACRA Perfusion Study [PDF]

Circulation: Cardiovascular Interventions, 2019
BACKGROUND: Transradial intervention (TRI) may impair digital perfusion with hand dysfunction as a result. However, the effect of TRI on digital perfusion has never been investigated, including the influence of variations of the collateral arterial network and the effect on hand dysfunction.
Leeuwen, M.A.H. van, Heijden, D.J. van der, Hollander, M.R., Mulder, M.J.H.L., Ven, P.M. van de, Ritt, M., Kiemeneij, F., Mieghem, N.M. van, Royen, N. van   +8 more
openaire   +4 more sources

Surface Contamination by Multidrug-Resistant Gram-Negative Bacteria in a Healthcare Facility: Resistance Determinants and Biofilm-Associated Adhesion. [PDF]

Int J Microbiol
Hospital surfaces represent a major reservoir of multidrug‐resistant Gram‐negative bacteria (MDR‐GNB), which contributes to healthcare‐associated infections. This study characterized the occurrence, resistance determinants, and biofilm‐forming behavior of MDR‐GNB isolated from hospital surfaces in a Moroccan regional hospital.
Dihmane A, Aniba R, Raqraq H, Ressmi A, Nayme K, Timinouni M, Barguigua A.   +6 more
europepmc   +2 more sources

Efflux Pump-Binding 4(3-Aminocyclobutyl)Pyrimidin-2-Amines Are Colloidal Aggregators

Biomolecules, 2023
Efflux pumps are a relevant factor in antimicrobial resistance. In E. coli, the tripartite efflux pump AcrAB-TolC removes a chemically diverse set of antibiotics from the bacterium.
Tania Szal, Shweta Singh Chauhan, Philipp Lewe, Fatima-Zahra Rachad, Marina Madre, Laura Paunina, Susanne Witt, Ramakrishnan Parthasarathi, Björn Windshügel   +8 more
doaj   +1 more source

Defining the RND-binding residues of AcrA

Access Microbiology, 2020
The resistance-nodulation-division (RND) family of efflux pumps confer clinically relevant antibiotic resistance in Gram-negative bacteria, such as Salmonella enterica. RND pumps, including AcrB, are organized as tri-partite systems, consisting of an inner membrane RND pump, a periplasmic adaptor protein (PAP) and an outer membrane channel. Previously,
Ilyas Alav, Ricardo Torres, Vassiliy Bavro, Jessica Blair   +3 more
openaire   +1 more source

Conformational restriction shapes the inhibition of a multidrug efflux adaptor protein

Nature Communications, 2023
Membrane efflux pumps play a major role in bacterial multidrug resistance. The tripartite multidrug efflux pump system from Escherichia coli, AcrAB-TolC, is a target for inhibition to lessen resistance development and restore antibiotic efficacy, with ...
Benjamin Russell Lewis, Muhammad R. Uddin, Mohammad Moniruzzaman, Katie M. Kuo, Anna J. Higgins, Laila M. N. Shah, Frank Sobott, Jerry M. Parks, Dietmar Hammerschmid, James C. Gumbart, Helen I. Zgurskaya, Eamonn Reading   +11 more
doaj   +1 more source