Results 11 to 20 of about 22,878 (213)

Development and validation of a novel diagnostic test for human brucellosis using a glyco-engineered antigen coupled to magnetic beads. [PDF]

PLoS Neglected Tropical Diseases, 2013
Brucellosis is a highly contagious zoonosis and still a major human health problem in endemic areas of the world. Although several diagnostic tools are available, most of them are difficult to implement especially in developing countries where complex ...
Andrés E Ciocchini, Diego A Rey Serantes, Luciano J Melli, Jeremy A Iwashkiw, Bettina Deodato, Jorge Wallach, Mario F Feldman, Juan E Ugalde, Diego J Comerci   +8 more
doaj   +6 more sources

Development of a set of bacterial engineered glycoconjugates as novel serogroup-specific antigens for the serodiagnosis of Escherichia coli O26, O111, O103 and O45 infections associated to hemolytic uremic syndrome [PDF]

Microbial Cell Factories
Hemolytic uremic syndrome associated to Shiga toxin-producing Escherichia coli infection (STEC-HUS) is a life-threatening condition characterized by microangiopathic hemolytic anemia, thrombocytopenia, and acute kidney failure. Among STEC, E.
Ana J. Caillava, Luciano J. Melli, Malena Landoni, Stella Maris Landivar, Isabel Chinen, Alicia S. Couto, Marta Rivas, Juan E. Ugalde, Diego J. Comerci, Andrés E. Ciocchini   +9 more
doaj   +2 more sources

Conformational Flexibility in the Multidrug Efflux System Protein AcrA [PDF]

Structure, 2006
Intrinsic resistance to multiple drugs in many gram-negative bacterial pathogens is conferred by resistance nodulation cell division efflux pumps, which are composed of three essential components as typified by the extensively characterized Escherichia coli AcrA-AcrB-TolC system.
Helen I Zgurskaya, Partho Ghosh
exaly   +3 more sources

Genetic analysis of acrA and lir mutations of Escherichia coli [PDF]

Journal of Bacteriology, 1982
An analysis of acrA (acriflavine- and methylene blue-sensitive) and lir (lincomycin- and erythromycin-sensitive) mutants of Escherichia coli indicated that these mutations are probably within the same gene.
J M, Henson, J R, Walker
exaly   +3 more sources

Molecular cloning and characterization of acrA and acrE genes of Escherichia coli [PDF]

Journal of Bacteriology, 1993
The DNA fragment containing the acrA locus of the Escherichia coli chromosome has been cloned by using a complementation test. The nucleotide sequence indicates the presence of two open reading frames (ORFs). Sequence analysis suggests that the first ORF encodes a 397-residue lipoprotein with a 24-amino-acid signal peptide at its N terminus.
D, Ma, D N, Cook, M, Alberti, N G, Pon, H, Nikaido, J E, Hearst   +5 more
exaly   +3 more sources

A widespread single amino acid mutation in AcrA reduces tigecycline susceptibility in Klebsiella pneumoniae

Microbiology Spectrum
Whole-genome sequencing of a clinical tigecycline non-susceptible Klebsiella pneumoniae strain reveals a novel T188A mutation in AcrA, raising awareness on its role in tigecycline resistance.
Mingyu Wang, Hai Xu, Xuhua Zhang
exaly   +3 more sources

Unravelling the Pathotype, Biofilm, Virulome and Resistome Profile of MultiDrug-Resistant Bacteria Isolated From Cattle Faeces Using Whole Genome Sequence Analysis. [PDF]

Int J Microbiol
The high mortality and morbidity resulting from diarrhoeal cases worldwide are associated with the increasing incidence of antimicrobial resistance (AMR) and represent a serious public health concern. Cattle are a major reservoir of AMR organisms, and faecal shedding may facilitate their transmission into the food chain.
Abolarinwa TO, Ajose DJ, Oluwarinde BO, Ewunkem AJ, Montso PK, Engohang-Ndong J, Callaway TR, Fayemi OE, Aremu AO, Ateba CN.   +9 more
europepmc   +2 more sources

Integrons and Efflux Pump-Mediated Antibiotic Resistance in Multidrug-Resistant (MDR) Uropathogenic Escherichia coli. [PDF]

Biomed Res Int
Objective Integrons facilitate the acquisition and expression of antibiotic resistance genes, with Classes 1 and 2 commonly found in clinical E. coli. The AcrAB–TolC efflux pump is a major RND system that expels diverse antimicrobial agents and contributes to resistance.
Gonbadi MA, Dini Y, Mohammadi M, Pournajaf A, Halaji M.   +4 more
europepmc   +2 more sources

ACRA Perfusion Study [PDF]

Circulation: Cardiovascular Interventions, 2019
BACKGROUND: Transradial intervention (TRI) may impair digital perfusion with hand dysfunction as a result. However, the effect of TRI on digital perfusion has never been investigated, including the influence of variations of the collateral arterial network and the effect on hand dysfunction.
Leeuwen, M.A.H. van, Heijden, D.J. van der, Hollander, M.R., Mulder, M.J.H.L., Ven, P.M. van de, Ritt, M., Kiemeneij, F., Mieghem, N.M. van, Royen, N. van   +8 more
openaire   +5 more sources

Efflux Pump-Binding 4(3-Aminocyclobutyl)Pyrimidin-2-Amines Are Colloidal Aggregators

Biomolecules, 2023
Efflux pumps are a relevant factor in antimicrobial resistance. In E. coli, the tripartite efflux pump AcrAB-TolC removes a chemically diverse set of antibiotics from the bacterium.
Tania Szal, Shweta Singh Chauhan, Philipp Lewe, Fatima-Zahra Rachad, Marina Madre, Laura Paunina, Susanne Witt, Ramakrishnan Parthasarathi, Björn Windshügel   +8 more
doaj   +1 more source