Results 101 to 110 of about 69,662 (247)

Multi‐Targeting Ligands as Prospective Therapeutics for Alzheimer's Disease, a Prevalent Neurodegenerative Disorder: Mechanistic Insights, Emerging Targets and Drug Discovery Campaigns

Medicinal Research Reviews, EarlyView.
ABSTRACT Alzheimer's disease (AD) is a debilitating neurodegenerative condition characterized by progressive cognitive impairment, memory deterioration, and neuronal dysfunction. Its complex pathophysiology involves multiple interlinked processes, including amyloid‐β (Aβ) aggregation, tau hyperphosphorylation, oxidative stress, neuroinflammation ...
Amandeep Thakur, Mandeep Rana, Sakshi Vanjani, Kei‐Chi Liou, Rajeev Taliyan, Kunal Nepali, Chih‐Hao Yang   +6 more
wiley   +1 more source

Multi‐target fluorescence staining of bacteria smears enables rapid machine learning‐assisted species classification

mLife, EarlyView.
Abstract Rapid identification of bacterial species from patient samples is crucial for clinical decision‐making. In severe infections, such as bloodstream infections, the early start of an effective treatment is directly associated with reduced mortality rates.
Maxence Galvan, Michael Fujarski, Can Beslendi, Frieder Schaumburg, Julian Varghese, Johannes Liesche   +5 more
wiley   +1 more source

Boron‐10 carriers and their applications in boron neutron capture therapy

Precision Radiation Oncology, EarlyView.
Summary of different types of boron drugs. Abstract Boron neutron capture therapy (BNCT) has emerged as a promising therapeutic modality in cancer treatment, demonstrating the ability to selectively eliminate cancer cells through the 10B(n,α)7Li nuclear reaction with minimal side effects on normal tissues.
Dachao Tang, Mengqi Shi, Zhichen Mao, Weiya Chen, Xiaoling Li, Xiao Yan Zhao, Zhigang Liu, Xiao Xu   +7 more
wiley   +1 more source

Cytotoxic Effect of Freeze-Dried Extract of Ecballium elaterium Fruit on Gastric Adenocarcinoma (AGS) and Esophageal Squamous Cell Carcinoma (KYSE30) Cell Lines [PDF]

Purpose Ecballium elaterium (L.) A. Rich (Cucurbitaceae), also known as the “squirting cucumber,” is a wild medicinal plant found abundantly in Moghan, Ardabil province, Iran.
بهلولی, شهاب, جاهد, شهرام, جعفری, ناصر   +2 more
core   +1 more source

Dual Role of Subphthalocyanine Dyes for Optical Imaging and Therapy of Cancer [PDF]

, 2018
This is the peer-reviewed version of the following article: van de Winckel, E., Mascaraque, M., Zamarrón, A., Juarranz de la Fuente, Á., Torres, T., & de la Escosura, A. (2018).
Escosura Navazo, Andrés de la, Juarranz de la Fuente, Ángeles, Mascaraque Checa, Marta, Torres Cebada, Tomás, van de Winckel, Eveline, Zamarrón, Alicia   +5 more
core   +1 more source

9-(2-Ethylphenoxycarbonyl)-10-methylacridinium trifluoromethanesulfonate

Acta Crystallographica Section E, 2010
In the crystal structure of the title compound, C23H20NO2+·CF3SO3−, the cations form inversion dimers through π–π interactions between the acridine ring systems.
Damian Trzybiński, Karol Krzymiński, Artur Sikorski, Piotr Malecha, Jerzy Błażejowski   +4 more
doaj   +1 more source

Fluorescence microscopy imaging with a Fresnel zone plate array based optofluidic microscope [PDF]

, 2011
We report the implementation of an on-chip microscope system, termed fluorescence optofluidic microscope (FOFM), which is capable of fluorescence microscopy imaging of samples in fluid media.
Han, Chao, Lee, Lap Man, Pang, Shuo, Yang, Changhuei   +3 more
core   +1 more source

Advances in the Different Synthetic Routes of Fluorinated Hydrazines

The Chemical Record, EarlyView.
This review highlights the various routes to the preparation of fluorinated hydrazines, thereby promoting the exploration of innovative methods for the synthesis of new N‐fluorinated hydrazines. Their synthesis mainly involves synthetic routes such as organometallic, organocatalytic, and photocatalytic.
Dimitra Kyrko, Benoît Crousse
wiley   +1 more source

Acridine orange fluorescent microscopy is more sensitive than India ink light microscopy in the rapid detection of cryptococcosis among CrAg positive HIV patients.

PLoS ONE, 2017
BackgroundIndia ink microscopy on cerebrospinal fluid is still utilized in resource limited settings for the diagnosis of cryptococcal meningitis despite its poor sensitivity.
Richard Kwizera, Andrew Akampurira, Darlisha Williams, David R Boulware, David B Meya, ASTRO-CM Study Team   +5 more
doaj   +1 more source

3,3-Dimethyl-10-(4-methoxyphenyl)-9-(4-nitrophenyl)-1,2,3,4,5,6,7,8,9,10-decahydroacridine-1,8-dioneContribution No. 20272019.

Acta Crystallographica Section E, 2008
The title compound, C28H28N2O5, consists of a partially hydrogenated acridine ring system with two substituted phenyl substituents on the dihydropyridine ring which are both nearly perpendicular to the mean plane of the acridine unit [dihedral angles of ...
Chunbao Miao, Changsheng Yao, Shujiang Tu, Xiaoqiang Sun   +3 more
doaj   +1 more source