Results 71 to 80 of about 69,601 (190)

Pharmacokinetics, Safety, and Efficacy of Intravitreal Digoxin in Preclinical Models for Retinoblastoma [PDF]

, 2015
PURPOSE:To assess in vitro cytotoxic activity and antiangiogenic effect, ocular and systemic disposition, and toxicity of digoxin in rabbits after intravitreal injection as a potential candidate for retinoblastoma treatment.METHODS:A panel of two ...
Abramson, David, Arana, Eloisa, Buitrago, Emiliano, Chantada, Guillermo Luis, Croxatto, Juan Oscar, del Sole, Maria Jose, Djaballah, Hakim, Francis, Jasmine, Laurent, Viviana Eunice, Mena, Hebe Agustina, Negrotto, Soledad, Schaiquevich, Paula Susana, Sgroi, Mariana, Winter, Ursula Andrea   +13 more
core   +2 more sources

Bis(tricyclic) Aromatic Enes That Exhibit Efficient Fluorescence in the Solid State

Molecules
We report herein that bis(tricyclic) aromatic enes (BAEs) consisting of 6-6-6-membered frameworks such as acridine, xanthene, thioxanthene, and thioxanthene-S,S-dioxide act as a new class of organic luminophores that exhibit blue-to-green fluorescence in
Masaki Shimizu, Kenta Nishimura, Mizuki Mineyama, Rin Terao, Tsuneaki Sakurai, Hiroshi Sakaguchi   +5 more
doaj   +1 more source

Electron Transfer-oxy Radical Mechanism for Anti-cancer Agents: 9-anilinoacridines [PDF]

, 1987
A possible mode of action involving electron transfer is advanced for the 9- anilinoacridines. The mechanism entails formation of toxic oxy radicals which destroy the neoplasm.
Ames, James R., Kovacic, Peter, Ryan, Michael D.   +2 more
core   +1 more source

In Vivo Antidiabetic and Antilipidemic Effect of Thiazolidine-2,4-Dione Linked Heterocyclic Scaffolds in Obesity-Induced Zebrafish Model

Pharmaceuticals
Background: Type 2 diabetes mellitus (T2DM) presents a significant global health challenge, with obesity being a major contributing risk factor alongside genetic and non-genetic elements.
Asmaa Galal-Khallaf, Dawlat Mousa, Aml Atyah, Mohamed El-Bahnsawye, Mona K. Abo Hussein, Ibrahim El Tantawy El Sayed, Elshaymaa I. Elmongy, Reem Binsuwaidan, Abdel Moneim A. K. El-Torgoman, Hamed Abdel-Bary, Khaled Mohammed-Geba   +10 more
doaj   +1 more source

2,6-Dimethylphenyl acridine-9-carboxylate

Acta Crystallographica Section E, 2013
In the title compound, C22H17NO2, the acridine ring system and the benzene ring are oriented at a dihedral angle of 37.7 (1)°. The carboxyl group is twisted at an angle of 67.7 (1)° relative to the acridine skeleton. In the crystal,
Damian Trzybiński, Michał Wera, Karol Krzymiński, Jerzy Błażejowski   +3 more
doaj   +1 more source

Detection of specific bacteria in water: implications of survival strategy [PDF]

, 1997
It is widely recognised that conventional culture techniques may underestimate true viable bacterial numbers by several orders of magnitude. The basis of this discrepancy is that a culture in or on media of high nutrient concentration is highly selective
Pickup, R.W., Rhodes, G.
core  

Synthesis of 9-substituted Acridine Derivatives and Evaluation of their Antifungal Activity against Phytopathogenic Fungi

Biomedical and Biotechnology Research Journal
Background: The emergence of pesticide resistance in phytopathogenic fungi significantly impacts global crop yields. In this study, three series of 39 9-substituted acridine derivatives were synthesized (13 each of 9-methyl, 9-formyl, and 9-formaldehyde ...
Tianhao Pang, Yanhui Zhao, Yuanze Sun, Xueqing Zhang, Wei Liu, Buer Song   +5 more
doaj   +1 more source

The Partner Does Matter: The Structure of Heteroaggregates of Acridine Orange in Water

Molecules, 2019
Self-assembly of organic molecules in aqueous solutions is governed by a delicate entropy/enthalpy balance. Even small changes in their intermolecular interactions can cause critical changes in the structure of the aggregates and their spectral ...
Ilya G. Shenderovich
doaj   +1 more source

Acetate to enhance electrochemical activity of biofilms from garden compost [PDF]

, 2008
Dimensionally Stable Anodes embedded in garden compost and maintained under constant polarization at 0.50 V/SCE for several days progressively became covered by a microbial biofilm that gave them the capability to oxidize the organic matter contained in ...
Bergel, Alain, Délia, Marie-Line, Parot, Sandrine   +2 more
core   +1 more source

Design, Synthesis, and Antimalarial Evaluation of New Spiroacridine Derivatives

Antibiotics
Background/Objectives: Malaria is a tropical disease mainly caused by Plasmodium falciparum and represents a global public health problem, with over 200 million cases and 500 thousand deaths reported worldwide.
Misael de Azevedo Teotônio Cavalcanti, Sonaly Lima Albino, Karla Joane da Silva Menezes, Wallyson Junio Santos de Araújo, Fernanda de França Genuíno Ramos Campos, Malu Maria Lucas dos Reis, Inês Morais, Denise Maria Figueiredo Araújo Duarte, Igor José dos Santos Nascimento, Valnês da Silva Rodrigues-Junior, Fátima Nogueira, Ricardo Olímpio de Moura   +11 more
doaj   +1 more source