Results 61 to 70 of about 69,258 (233)

Microfluidic Hydroporation Platform for Effective Allogeneic CAR‐T Cell Production and Subsequent Functional Cytotoxicity Analysis

Advanced Materials Technologies, EarlyView.
The hydroporator platform employs controlled hydrodynamic deformation for efficient mRNA and CRISPR/Cas9 delivery into primary human T cells, enabling allogeneic CAR‐T cell manufacturing. It preserves cell functionality and drives potent gene editing, CAR expression, and tumor cytotoxicity, while feature‐based analysis links these functional outcomes ...
Soohyun Jeon, Sein Kim, Hyun‐Young Kim, Duck Cho, Sungsu Park, Seohyun Kim, Aram J. Chung   +6 more
wiley   +1 more source

Towards Understanding the Structure, Dynamics and Bio-activity of Diabetic Drug Metformin

, 2018
Small molecules are often found to exhibit extraordinarily diverse biological activities. Metformin is one of them. It is widely used as anti-diabetic drug for type-two diabetes.
Bagchi, Biman, Bhattacharyya, Aninda J, Mondal, Sayantan, Mukherjee, Saumyak, Samajdar, Rudra N   +4 more
core   +1 more source

Disulfide‐Bridged Ru Complex–Mediated Photo‐Disulfidptosis for Colorectal Cancer Therapy

Advanced Science, EarlyView.
In this work, a binuclear ruthenium complex, RuSSRu was developed for efficient colorectal cancer (CRC) treatment. The synergistic interaction between disulfidptosis and lysosomal damage‐induced apoptosis induced by RuSSRu amplified tumor cell death. This innovative approach offers a potent therapeutic strategy for CRC.
Simeng He, Wendong Jin, Jiaojiao Pang, Xiaoting Gong, Shixian Cao, Duo Mao, Yuguo Chen, Kang‐Nan Wang, Bin Liu   +8 more
wiley   +1 more source

Steric and Electronic Effects in N-Heterocyclic Carbene Gold(III) Complexes: An Experimental and Computational Study

Molecules, 2022
A series of neutral acridine-based gold(III)-NHC complexes containing the pentafluorophenyl (–C6F5) group were synthesized. All of the complexes were fully characterized by analytical techniques.
Miguel A. Rosero-Mafla, Jhon Zapata-Rivera, M. Concepción Gimeno, Renso Visbal   +3 more
doaj   +1 more source

Diabetes Mellitus Facilitates Gallstone Formation Through CXCR2‐NETs–Mediated Liver‐Bile Barrier Damage

Advanced Science, EarlyView.
Diabetes is an independent risk factor for gallstones. It upregulates CXCR2 expression in hepatic neutrophils, stimulating the formation of NETs that disrupt hepatocellular tight junctions and the liver‐bile barrier. NETs enter bile to accelerate gallstone development, while sarcosine inhibits CXCR2 and NETs production, effectively reducing diabetes ...
Chao Shi, Shuo Feng, Tianming Liu, Ziang Meng, Yi Zheng, Zhenghao Huang, Tong Wang, Bojian Zhang, Dongbo Xue, Biao Ma, Xianzhi Meng   +10 more
wiley   +1 more source

Molecular modelling studies of binding of DACD derivatives into G-Quadruplex DNA: comparison of force field and quantum polarized ligand docking methods [PDF]

, 2012
The DNA G-qadruplexes are one of the targets being actively explored for anti-cancer therapy by inhibiting them through small molecules. This computational study was conducted to predict the binding strengths and orientations of a set of novel dimethyl ...
Cardin, Christine J., Subramanian, Arun Kumar   +1 more
core  

Effects of a Four-Week High-Dosage Zinc Oxide Supplemented Diet on Commensal Escherichia coli of Weaned Pigs [PDF]

, 2019
Strategies to reduce economic losses associated with post-weaning diarrhea in pig farming include high-level dietary zinc oxide supplementation.
Bethe, Astrid, Eichhorn, Inga, Epping, Lennard, Ghazisaeedi, Fereshteh, Johanns, Vanessa C., Lübke-Becker, Antina, Merle, Roswitha, Pfeifer, Yvonne, Semmler, Torsten, Walther, Birgit, Wieler, Lothar H.   +10 more
core   +2 more sources

Stochastic models (cooperative and non-cooperative) for NMR analysis of the hetero-association of aromatic molecules in aqueous solution [PDF]

, 2006
Stochastic cooperative (STOCH-C) and non-cooperative (STOCH-NC) models have been developed for NMR analysis of the hetero-association of aromatic compounds in solution, in order to take into account all physically meaningful association reactions of ...
Davies, David B., Evstigneev, M.P., Veselkov, A.N.   +2 more
core   +1 more source

Bis(tricyclic) Aromatic Enes That Exhibit Efficient Fluorescence in the Solid State

Molecules
We report herein that bis(tricyclic) aromatic enes (BAEs) consisting of 6-6-6-membered frameworks such as acridine, xanthene, thioxanthene, and thioxanthene-S,S-dioxide act as a new class of organic luminophores that exhibit blue-to-green fluorescence in
Masaki Shimizu, Kenta Nishimura, Mizuki Mineyama, Rin Terao, Tsuneaki Sakurai, Hiroshi Sakaguchi   +5 more
doaj   +1 more source

Characteristics of E. coli K12 strains carrying both an F prime and an R factor [PDF]

, 1970
The interrelationship between an F prime and an F-like or I-like R factor was studied in Escherichia coli K 12 strains carrying both. The donorability of such strains suggested that these plasmids were transferred independently by their own transfer ...
Finnegan, David, WILLETTS, N S
core   +1 more source