Results 51 to 60 of about 53,333 (203)

Solvent and Isotopic Effects on Acridine and Deuterated Acridine Polymorphism

, 2016
The influence of pure solvents (p.a.) and impure solvents (techn. quality) on the crystallization of polymorphic forms of non-, partial-, and per-deuterated acridine from solution was investigated.
A. Kupka (1797103), V. Vasylyeva (2016676), D. W. M. Hofmann (2016679), K. Merz (1797100), Kirill V. Yusenko (1719823)   +4 more
core   +1 more source

Interaction of acridine-calix[4]arene with DNA at the electrified liquid|liquid interface [PDF]

, 2010
The behaviour of an acridine-functionalised calix[4]arene at the interface between two immiscible electrolyte solutions (ITIES) is reported. Molecular modelling showed that the acridine-calix[4]arene has regions of significant net positive charge spread ...
Lefoix, M., Ogurtsov, V., Herzog, G., Thompson, D., Kivlehan, F., Moynihan, H., Arrigan, Damien, Francine Kivlehan, Humphrey A. Moynihan, Damien W.M. Arrigan, Vladimir I. Ogurtsov, Damien Thompson, Grégoire Herzog, Myriam Lefoix   +13 more
core   +2 more sources

An Avalanche Effect Nanomodulator Triggers Cascade Ferroptosis/Cuproptosis for Immunosuppressive Microenvironment Remodeling

Advanced Science, EarlyView.
A nanomodulator called L‐Arginine/lificiguat@Copper‐hollow Prussian blue@Calcium phosphate nanoparticles is constructed to launch a self‐amplifying “avalanche effect” in tumor cells. The ensuing cascade, triggered by the acidic tumor microenvironment and near‐infrared light, induces calcium overload, generates a reactive oxygen species and reactive ...
Hongmei Zhou, Caixi Yu, Guilan Xu, Lijuan Liu, Yujia Liang, Yulin Liang, He Ding, Litu Zhang, Piaoping Yang, Chen Wang   +9 more
wiley   +1 more source

Aggregation of N-Heteropolycyclic Aromatic Molecules: The Acridine Dimer and Trimer [PDF]

Polycyclic aromatic hydrocarbons and their nitrogen-substituted analogues are of great interest for various applications in organic electronics. The performance of such devices is determined not only by the properties of the single molecules, but also by
Andreas, Dreuw, Marco, Bauer, Hans-Jörg, Himmel, Stefan, Germer, Olaf, Hübner   +4 more
core   +2 more sources

Molecular Signatures of HIV‐Induced Neuroinflammation and Neurodegeneration in Human Cerebral Organoids: Identification of Therapeutic Targets for NeuroHIV

Advanced Science, EarlyView.
HIV preferentially infects microglia, activating IL‐17A‐driven IFN‐γ/STAT1, CEBPB, and NF‐κB signaling that converges with cGAS‐STING and Notch–NEURL1 pathways, promoting neuroinflammation, mitochondrial dysfunction, and synaptic impairment. cART suppresses viral replication, attenuates inflammatory signaling, and at least partially restores ...
Karthick Chennakesavan, Malaroviyam Samikkannu, Shreyan Gupta, Olasunkanmi Israel Tayo, Arpan Acharya, James J. Cai, Siddappa N. Byrareddy, Thangavel Samikkannu   +7 more
wiley   +1 more source

Amide-based derivatives of acridine display multifaceted anticancer targeting: An in silico-based mechanistic study [PDF]

Journal of Pharmacy & Pharmacognosy Research
Context: The ongoing challenges with chemotherapy demand continuous efforts to discover new drug molecules. In this scenario, a multi-target approach could be of special advantage.
Saad Touqeer, Sedq A. Moutraji
doaj   +1 more source

Early‐Life Manganese Overexposure Activates Microglial Phagocytosis through the YY1/TREM2 Axis Leading to Hippocampal Synaptic Remodeling in Mice

Advanced Science, EarlyView.
Early‐life manganese exposure induces behavioral deficits and aberrant hippocampal synaptic remodeling by enhancing microglial phagocytosis in young adult male mice. Mechanistically, manganese promotes Yin Yang 1 (YY1)/triggering receptor expressed on myeloid cells 2 (TREM2) signaling through enhanced HIF1α‐mediated transcription and suppressed SMURF2 ...
Keyu Chen, Bin He, Kuan Liu, Zhuo Ma, Bin Xu   +4 more
wiley   +1 more source

Determination of Acridine, Benz[c]acridine and Dibenz[a,h]acridine by Fast Scan Differential Pulse Voltammetry and Adsorptive Stripping Voltammetry

, 1994
The behaviour of the title compounds in fast scan differential pulse voltammetry and adsorptive stripping voltammetry was studied and the optimum conditions were found for their determination by FS DPV over the concentration region of (2 - 100) .10-7 mol
Jiří Zima, Jiří Barek, Jaroslav Matějka   +2 more
core   +1 more source

Lithium‐Doped Hydroxyapatite Nanowires Rejuvenate Senescent Macrophages Via the Lysosome‐Dependent Ferroptosis Axis to Promote Aged Bone Regeneration

Advanced Science, EarlyView.
Li‐nHAP+GelMA promotes mandibular bone regeneration in aged mice by remodeling the senescent immune microenvironment. Local delivery of Li‐nHAP restores lysosomal homeostasis in senescent macrophages, reduces intracellular labile Fe2+ accumulation, ROS production, and lipid peroxidation, thereby suppressing macrophage ferroptosis and senescence ...
Baixi Chen, Ziduan Ding, Ruomei Li, Cheng Zhu, Zhiyu Zhu, Zitong Yang, Luyao Qu, Jin Hao, Lunguo Xia, Bing Fang, Lu Liu   +10 more
wiley   +1 more source

Bis(tricyclic) Aromatic Enes That Exhibit Efficient Fluorescence in the Solid State

Molecules
We report herein that bis(tricyclic) aromatic enes (BAEs) consisting of 6-6-6-membered frameworks such as acridine, xanthene, thioxanthene, and thioxanthene-S,S-dioxide act as a new class of organic luminophores that exhibit blue-to-green fluorescence in
Masaki Shimizu, Kenta Nishimura, Mizuki Mineyama, Rin Terao, Tsuneaki Sakurai, Hiroshi Sakaguchi   +5 more
doaj   +1 more source