Results 81 to 90 of about 45,976 (189)

Tau‐targeting active immunotherapy slows progression and reduces pathology in mouse models of tauopathy

Brain Pathology, EarlyView.
The efficacy of the novel anti‐tau active immunotherapy, p5555kb, was tested using two mouse models of tau pathology. p5555kb inoculation increased the survival rate and reduced tau pathology in tau‐overexpressing P301L mice and decreased tau seeding in the brains of C57BL/6 mice injected with human‐purified Alzheimer's disease tau.
Christopher M. Brown, Jeanne K. Brooks, Louise Kelly, Madeline M. Vroom, Matthew Longo, Jean‐Cosme Dodart, Roxana Carare, Justin D. Boyd   +7 more
wiley   +1 more source

Cyclin‐dependent kinase 13 is indispensable for normal mouse heart development

Journal of Anatomy, Volume 246, Issue 4, Page 616-630, April 2025.
Congenital heart disease (CHD) is the most common defect in live births. The role of cyclin‐dependent kinase (CDK13) in cardiogenesis and CHD was studied using a transgenic mouse model (Cdk13tm1b) carrying deletion of exons 3 and 4, causing loss of function.
Qazi Waheed‐Ullah, Anna Wilsdon, Aseel Abbad, Sophie Rochette, Frances Bu'Lock, Asma Ali Saed, Marc‐Phillip Hitz, J. David Brook, Siobhan Loughna   +8 more
wiley   +1 more source

The role of acquired host immunity in periodontal diseases

Periodontology 2000, EarlyView.
Abstract The aim of this narrative review is to relate the contribution of European researchers to the complex topic of the host immune system in periodontal disease, focusing on acquired immunity. Other chapters in this volume will address the genetics and autoantibody responses and other forms of immunity to periodontal disease.
Denis F. Kinane, David F. Lappin, Shauna Culshaw   +2 more
wiley   +1 more source

Luminescence in DNA-Acridine Dye Complexes. I. Phosphorescence and Delayed Fluorescence Due to the Triplet-Triplet Annihilation of Acridine Dyes in the Complexes [PDF]

, 1970
Yukio Kubota
openalex   +1 more source

Viable but Nonculturable State, a Survival Strategy for Salmonella in Aquatic Environments

Water and Environment Journal, EarlyView.
Transition of Salmonella from a culturable state to a viable but nonculturable state under various environmental stresses and current methods for detecting viable Salmonella in environmental samples. ABSTRACT In the relentless battle for survival, Salmonella has evolved mechanisms to withstand harsh conditions such as extreme temperatures, fluctuating ...
Sanelisiwe Thinasonke Duze, Musa Marimani, Katlego Mamabolo, Mrudula Patel   +3 more
wiley   +1 more source

Low‐Head Dam Removal Restores Biofilm Structure but Not Function in a Temperate Stream

International Review of Hydrobiology, Volume 111, Issue 1, June 2026.
ABSTRACT Barrier removal is a common stream restoration practice aimed at restoring longitudinal connectivity, yet its effects on biofilm structure and function, through alteration of near‐bed hydrodynamics, remain unclear. Using a space‐for‐time substitution approach, we assessed how the presence and removal of a low‐head dam affect biofilm structure ...
Julia Pasqualini, Christine Anlanger, Clara Mendoza‐Lera, Patrick Fink, Andreas Lorke, Markus Weitere, Ulisses Nunes da Rocha, Kay Knöller, Travis Meador, Mario Brauns   +9 more
wiley   +1 more source

Targeting Expanded CUG and CTG Repeats as a Therapeutic Approach for Myotonic Dystrophy Type 1 (DM1)

ChemMedChem, Volume 21, Issue 5, 13 March 2026.
DM1 is an RNA gain‐of‐function disease caused by CTG repeat expansion, producing toxic r(CUG)exp RNA that sequesters MBNL1 and impairs splicing. This review covers the field of CUG and CTG ligands identified or rationally designed as DM1 drug candidates, highlighting their molecular design, RNA‐ or DNA‐binding modes, in vitro affinities and ...
Camille Richagneux, Anton Granzhan
wiley   +1 more source

DESIGN SYNTHESIS OF NOVEL ACRIDINE TAGGED PYRAZOLE DERIVATIVES AS AURORA KINASE INHIBITORS

, 2020
HARATHI PERKA, D SATYAVATI, DEEPAK REDDY GADE, VIVEKANANDA BOYA, RAJENDRA PRASAD VVS   +4 more
openalex   +1 more source

Bioinspired Bromination Enables Extensible, Strain‐Stiffening Resilin Peptide Scaffolds with Tunable Degradation

Advanced Functional Materials, Volume 36, Issue 19, 5 March 2026.
Bioinspired bromination of a resilin‐derived peptide enables the fabrication of electrospun nanofibrous scaffolds that uniquely combine strain‐stiffening elasticity, proteolytic stability, and antioxidant functionality. These brominated peptide–gelatin hybrids mimic the extensibility of natural elastomers, demonstrating tunable mechanical resilience ...
Elisa Marelli, Lorenzo Sori, Chiara Russo, Claudia Pigliacelli, Lorenza Draghi, Monica Soncini, Pierangelo Metrangolo   +6 more
wiley   +1 more source

Synthesis, Properties, Applications and Challenges of Multicomponent Doped Organic Room Temperature Phosphorescence Materials

Aggregate, Volume 7, Issue 3, March 2026.
The multi‐component doping strategy, involving self‐assembly, host‐guest systems, and crystal engineering, has gained attention for its simplicity, cost‐effectiveness, structural diversity, and adjustable room‐temperature phosphorescence (RTP). This review summarizes and evaluates the progress in creating RTP materials using this strategy, highlighting
Zhenjie Zhou, Huizhong Wang, Junxiong Yao, Tian Wang, Jianhua Liu, Xiaohua Cao, Qiang Feng, Bingbing Yue, Dianyuan Wang, Jianguo Wang, Huanan Huang   +10 more
wiley   +1 more source