Results 141 to 150 of about 28,434 (232)

Tracking tau and cellular responses in human iPSC‐microglia: from uptake to seedable secretion, including in extracellular vesicles

Alzheimer's &Dementia, Volume 22, Issue 4, April 2026.
Abstract INTRODUCTION Microglia have been implicated in the templated spread of tau aggregates in tauopathies through mouse studies. However, it is unclear whether these findings translate to human disease. METHODS We challenged human induced pluripotent stem cell (iPSC)‐derived microglia‐like‐cells (iMGL) with monomeric and fibrillar recombinant tau ...
Maria Kreger Karabova, Anna del Ser‐Badia, Anne Hedegaard, Sam J. Washer, Zeynep Baykam, Darragh P. O'Brien, Iolanda Vendrell, Svenja S. Hester, Roman Fischer, Errin Johnson, Charlotte E. Melia, Teige R. S. Matthews‐Palmer, Rishi Matadeen, Alessia Santambrogio, Michael A. Metrick II, Michele Vendruscolo, Sophie Keeling, Kimberly Ai Xian Cheam, William A. McEwan, Kenneth S. Kosik, Theresa A. Day, William S. James, Sally A. Cowley   +22 more
wiley   +1 more source

2-Aminophenones, a common precursor to N-aryl isatins and acridines endowed with bioactivities

, 2018
N. Brikci-Nigassa, Ghenia Bentabed‐Ababsa, W. Erb, F. Chevallier, Laurent Picot, Lucille Vitek, Audrey Fleury, V. Thiéry, Mohamed Souab, Thomas Robert, S. Ruchaud, S. Bach, T. Roisnel, F. Mongin   +13 more
semanticscholar   +1 more source

Biotic–Abiotic Hybrid Strategies for Photosynthetic Nitrogen Fixation and Green Ammonia Synthesis

ChemistryEurope, Volume 4, Issue 4, April 2026.
Biotic‐abiotic photosynthetic systems integrate light‐harvesting semiconductors with nitrogenase's selective N2 reduction under ambient conditions, offering a sustainable alternative to conventional ammonia synthesis. Advancing rational interface design, efficient energy‐reaction coupling, and system integration is critical to realizing scalable, solar‐
Minghua Xu, Depeng Meng, Xiaowen Ruan, Sai Kishore Ravi   +3 more
wiley   +1 more source

Review of recent advances in the design, synthesis, and modification of biochar for remediation of heavy metal pollution in water

The Canadian Journal of Chemical Engineering, Volume 104, Issue 4, Page 1769-1795, April 2026.
Research frontiers in using biochar for heavy metal remediation. Abstract Heavy metal contamination of water has long been a serious environmental issue. Biochar and biochar‐based composites are emerging as effective and sustainable solutions for heavy metal removal due to their strong adsorption abilities and environmentally friendly nature.
Soumik Chakma, Mehedi Hasan, Sudip K. Rakshit, Janusz Kozinski, Kang Kang   +4 more
wiley   +1 more source

Spatial and single‐cell RNA sequencing reveals the immune microenvironment of human ascending thoracic aortic aneurysms

Clinical and Translational Medicine, Volume 16, Issue 4, April 2026.
This study has used integrated single‐cell RNA sequencing and Visium HD spatial transcriptomics to construct a high‐resolution immune cell atlas of human ascending thoracic aortic aneurysms (ATAA). The analysis reveals distinct immune cell composition and interactions in ATAA tissues, providing new insights into immune dysregulation and vascular ...
Ke Zhen, Zhiyong Du, Pengcheng Wang, Song Liu, Junming Zhu, Zhiyu Qiao, Hongfeng Jiang   +6 more
wiley   +1 more source

Dispersion-Enhanced Nitrogen-Centered Photocatalysis of the Direct Hydrogen Atom Transfer. [PDF]

Angew Chem Int Ed Engl
Zhang J, Zhuang K, Trevino R, Dhungana BR, Sun H, Yin S, Li Y, Sanchez JA, Xia X, Elerian R, Sun Y, Fremin SO, Huang C, He M, Cheng M, Larionov OV, Jin S.   +16 more
europepmc   +1 more source

Phyllanthus emblica Exerts Therapeutic Potential in Oral Cancer Through Multiple Pathways

eFood, Volume 7, Issue 2, April 2026.
Graphic Illustration of the Multifaceted Therapeutic Potential of PEWE, 1. Phyllanthus emblica water extract (PEWE) demonstrates potent anticancer effects against oral cancer by inhibiting cell proliferation, migration, and invasion while inducing apoptosis and autophagy. 2.
Tai‐Pei Lin, Min‐Hsiung Pan, Chan‐Hua Chang, Kuan‐Chung Hsiao, Yen‐Lin Chen, Jui‐Sheng Lai, Wen‐Chan Yang, Ann‐Joy Cheng, Yin‐Ju Chen, Chiou‐Ying Yang, Meng‐Yuan Huang, Ko‐Jiunn Liu   +11 more
wiley   +1 more source

Identification of a group of 9-amino-acridines that selectively downregulate regulatory T cell functions through FoxP3. [PDF]

iScience
Wei Q, Foyn H, Landskron J, Wang S, Rye IH, Skånland SS, Russnes HEG, Klaveness J, Ahmad R, Taskén K.   +9 more
europepmc   +1 more source

Polydatin Relieves Airway Remodeling by Inhibiting P2X7R–NLRP3‐Mediated Excessive Autophagy in Asthma

Immunity, Inflammation and Disease, Volume 14, Issue 4, April 2026.
ABSTRACT Background Asthma is characterized by chronic airway inflammation and remodeling. Polydatin (PD), a natural compound, has shown anti‐inflammatory potential, but its role in asthma‐related airway remodeling and the underlying mechanisms involving the P2X7R–NLRP3 inflammasome axis and autophagy remain unclear.
Guangxing Li, Liangchang Li, Zhiguang Wang, Yihua Piao, Yilan Song, Li Li, Chang Xu, Xiaowan Li, Guanghai Yan   +8 more
wiley   +1 more source

Revolutionizing acridine synthesis: novel core-shell magnetic nanoparticles and Co-Zn zeolitic imidazolate framework with 1-aza-18-crown-6-ether-Ni catalysts. [PDF]

Sci Rep
Asadzadeh F, Poursattar Marjani A.
europepmc   +1 more source