Results 91 to 100 of about 380 (142)

Quinoline, quinazoline, and acridone alkaloids

Natural Product Reports, 1984
The most interesting new alkaloids are the acridones that contain tropone rings, which have been isolated from Citrus species. Emphasis this year is again on synthesis, with highlights including the first use of copper acetylides in the synthesis of furoquinolones, the synthesis of the (1,l -dimethylallyl)quinolinone buchapine, and developments in the ...
openaire   +4 more sources

Vibrational properties of the free and adsorbed acridone

Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 2004
Theoretical density functional theory (DFT) calculation, ab initio and experimental vibrational characterization of acridone were performed. The computed vibrational modes agree well with the experimental values of the related crystal structure. Surface enhanced Raman scattering (SERS) of acridone in silver colloids with different surface potential ...
S, Cîntã Pînzaru, C, Morari
openaire   +2 more sources

Synthesis of the acridone alkaloids, glyfoline and congeners. Structure-activity relationship studies of cytotoxic acridones

Journal of Medicinal Chemistry, 1992
Glyfoline (4, 1,6-dihydroxy-10-methyl-2,3,4,5-tetramethoxyacridin-9-one) and its congeners were synthesized for evaluation of their cytotoxicity. A detailed structure-activity relationships (SAR) of these acridone derivatives were also studied. To study the SAR of glyfoline analogues, substituent(s) at C-1 and C-6 and at the heterocyclic nitrogen of ...
T L, Su, B, Köhler, T C, Chou, M W, Chun, K A, Watanabe   +4 more
openaire   +2 more sources

Reactions in the Acridone‐Fields.

Helvetica Chimica Acta, 1976
Abstract1‐Chlor‐ und 1,7‐Dichlor‐4‐nitro‐acridon wurden mit einigen Phenolen und Bisphenolen zu Farbstoffen umgesetzt, die Polyvinylchlorid grünlichgelb färben. Im Xenotest 800 Std. belichtet, zeigten die einfachen Acridone IX bis XIII eine ungewöhnlich hohe Lichtechtheit; sie sind aber migrationsunecht.
openaire   +1 more source

Acridone Heterocycles as Fluorescent Sensors for Anions

HETEROCYCLES, 2006
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
M. Teresa Blazquez, Francisco M. Muniz, Silvia Saez, Luis M. Simon, Angel Alonso, Cesar Raposo, Anna Lithgow, Victoria Alcazar, Joaquin R. Moran   +8 more
openaire   +1 more source

Equilibrium NH acidities of acridan, phenanthridone, 9-acridone, and substituted 9-acridones

Chemistry of Heterocyclic Compounds, 1982
The equilibrium NH acidities of acridan, phenanthridone, 9-acridone, and 2-substituted 9-acridones (substituents: Me2N, MeO, F, Br, I, and NO2) were measured by transmetallation in dimethyl sulfoxide (DMSO). The role of conjugation and the aromatic character of the heterocyclic ring in stabilization of the anions is discussed.
N. N. Voinovskaya, M. I. Terekhova, T. V. Sakhno, G. A. Val'kova, L. F. Rybakova, �. S. Petrov, A. I. Shatenshtein   +6 more
openaire   +1 more source

Design and Synthesis of Modified Quinolones as Antitumoral Acridones

Journal of Medicinal Chemistry, 1999
The bacterial topoisomerase II (DNA gyrase) and the mammalian topoisomerase II represent the cellular targets for quinolone antibacterials and a wide variety of anticancer drugs, respectively. In view of the mechanistic similarities and sequence homologies exhibited by the two enzymes, tentative efforts to selectively shift from an antibacterial to an ...
TABARRINI, Oriana, CECCHETTI, Violetta, FRAVOLINI, Arnaldo, NOCENTINI, Giuseppe, Barzi A., SABATINI, STEFANO, Miao H., Sissi C.   +7 more
openaire   +2 more sources

Antiprotozoal Activity and DNA Binding of Dicationic Acridones

Journal of Medicinal Chemistry, 2015
Dicationic acridone derivatives were synthesized and their antiparasitic activity was evaluated. Acridones displayed in vitro nanomolar IC50 values against Trypanosoma brucei rhodesiense STIB900 with selectivity indices >1000. Compounds 1b, 3a, and 3b were as potent as the reference drug melarsoprol in this assay.
Montalvo-Quirós, Sandra, Taladriz-Sender, Andrea, Kaiser, Marcel, Dardonville, Christophe   +3 more
openaire   +5 more sources

Mass Spectra of Acridone Alkaloids

Journal of the Chinese Chemical Society, 1989
AbstractThe mass spectra of a variety of simple acridones, prenylacridones, pyranoacridones, dihydropyranoacridones, and furoacridones are presented and discussed. The results illustrate that the characteristic fragmentation patterns are of considerable utility in the application of mass spectrometry to structure elucidation in the acridone alkaloids.
Shaw‐Tao Lin, Tian‐Shung Wu
openaire   +1 more source

9-Acridone from 2,2′-diaminobenzophenone

J. Chem. Soc. C, 1966
9-Acridone and 3,6-dichloro-9-acridone have been prepared in high yields by treatment of the corresponding 2,2′-diaminobenzophenones with 100% phosphoric acid. Boiling hydrochloric acid does not effect these cyclisations.
openaire   +2 more sources