Results 141 to 150 of about 2,769 (197)

Synthesis of Acridones by Palladium-Catalyzed Buchwald–Hartwig Amination

Synlett : Accounts and Rapid Communications in Synthetic Organic Chemistry, 2019
The Buchwald–Hartwig amination allows an efficient and convenient synthesis of biologically and pharmaceutically important acridones by formation of a six-membered ring. With the described method, a number of derivatives have been synthesized in up to 95%
J. Janke, A. Villinger, Peter Ehlers, P. Langer   +3 more
semanticscholar   +1 more source

Synthesis, cytotoxicity evaluation, and molecular modeling studies of 2,N10-substituted acridones as DNA-intercalating agents

Journal Chemical Research, 2020
Acridine-based compounds possess anticancer activities by intercalating to DNA. Although they have chemotherapeutic potential, acridine-based compounds are not used to treat cancer.
Nisachon Khunnawutmanotham, Watthanachai Jumpathong, Chatchakorn Eurtivong, N. Chimnoi, S. Techasakul   +4 more
semanticscholar   +1 more source

Equilibrium NH acidities of acridan, phenanthridone, 9-acridone, and substituted 9-acridones

Chemistry of Heterocyclic Compounds, 1982
The equilibrium NH acidities of acridan, phenanthridone, 9-acridone, and 2-substituted 9-acridones (substituents: Me2N, MeO, F, Br, I, and NO2) were measured by transmetallation in dimethyl sulfoxide (DMSO). The role of conjugation and the aromatic character of the heterocyclic ring in stabilization of the anions is discussed.
N. N. Voinovskaya, M. I. Terekhova, T. V. Sakhno, G. A. Val'kova, L. F. Rybakova, �. S. Petrov, A. I. Shatenshtein   +6 more
openaire   +1 more source

Acridone Alkaloids

2017
There have been substantial developments in the chemistry and biology of the acridone alkaloids in the 16years since the topic was last reviewed in this series of monographs (2000). The present survey covers the literature from mid-1999 to 2016. A brief overview of the biosynthesis of acridone alkaloids is followed by details of the occurrence and ...
openaire   +2 more sources

New Acridone Alkaloids from Citrus Plants

HETEROCYCLES, 1992
The spectroscopic structure elucidations of five new acridone alkaloids named yukocitrine (1), yukodine (3), Yukodinine (4), grandisine-III (6) and pummeline (7) from some Citrus plants were ...
Motoharu Ju-ichi, Yuko Takemura, Junko Kuwahara, Noriko Nagareya, Mitsuo Omura, Ichiro Kajiura, Ichiro Ito, Hiroshi Furukawa   +7 more
openaire   +1 more source

Elucidation of chemosensitization effect of acridones in cancer cell lines: Combined pharmacophore modeling, 3D QSAR, and molecular dynamics studies

Comput. Biol. Chem., 2018
Overexpression of P-glycoprotein (P-gp) leads to the emergence of multidrug resistance (MDR) in cancer treatment. Acridones have the potential to reverse MDR and sensitize cells.
D. Gade, Amareswararao Makkapati, R. Yarlagadda, G. Peters, B. Sastry, V. R. Prasad   +5 more
semanticscholar   +1 more source

Structural tuning of acridones for developing anticancer agents targeting dihydrofolate reductase.

Bioorganic & Medicinal Chemistry Letters, 2019
Targeting dihydrofolate reductase, here, we report the tumor growth inhibitory activity of substituted acridones. The screening of the molecules over 60 cell line panel of human cancer cells identified (S)-oxiran-2-ylmethyl 9-oxo-9,10-dihydroacridine-4 ...
Harpreet Singh, M. Kaur, H. Kaur, I. Sharma, Anmol Bhandari, G. Kaur, Palwinder Singh   +6 more
semanticscholar   +1 more source

Quinoline, quinazoline, and acridone alkaloids

Natural Product Reports, 1984
The most interesting new alkaloids are the acridones that contain tropone rings, which have been isolated from Citrus species. Emphasis this year is again on synthesis, with highlights including the first use of copper acetylides in the synthesis of furoquinolones, the synthesis of the (1,l -dimethylallyl)quinolinone buchapine, and developments in the ...
openaire   +4 more sources

Synthesis of acridones through palladium-catalyzed carbonylative of 2-bromo-diarylamines

Tetrahedron Letters, 2018
A facile protocol for the synthesis of acridone derivatives has been developed through palladium-catalyzed carbonylation/C H activation sequence from 2-bromo-diarylamines in moderate to excellent yields.
Juan Song, Keran Ding, Wei Sun, Songjiang Wang, Haisen Sun, K. Xiao, Yan Qian, Chao Liu   +7 more
semanticscholar   +1 more source

Biomimetic synthesis of acridone alkaloids

Journal of the Chemical Society, Perkin Transactions 1, 1977
Cyclisations of 2′-amino-, 2′-acetylamino-, or 2′-methylamino-2-methoxybenzophenones occur in the presence of sodium hydride in dimethyl sulphoxide to give acridone alkaloids. This cyclisation has relevance to the biosynthesis of these alkaloids. An alternative cyclisation can occur, giving 4-arylquinolines or 4-arylquinolones.
Joyce H. Adams, Padma Gupta, M. Shafiq Khan, John R. Lewis   +3 more
openaire   +1 more source