Results 41 to 50 of about 601 (168)

Boron Neutron Capture Therapy at a Crossroads: Translational Gap and Emerging Delivery Agents

open access: yesChemistry – A European Journal, Volume 32, Issue 17, 5 May 2026.
This review surveys recent advances in boron delivery agents for BNCT, emphasizing the shift from classical small molecules to multifunctional nanocarriers and theranostic systems. By integrating targeting, imaging, and therapy, next‐generation boron compounds aim to bridge the gap between (bio)chemical innovation and clinical translation.
Christoph Selg, Evamarie Hey‐Hawkins
wiley   +1 more source

Enzymatic synthesis of bioactive quinolones and (thio)coumarins by fungal type III polyketide synthases

open access: yesThe FEBS Journal, Volume 293, Issue 9, Page 2673-2691, May 2026.
Quinolones are valuable scaffolds for drug discovery but are rare in nature. Here, we show that two fungal enzymes, AthePKS and FerePKS, can generate 2‐quinolones and two additional heteroaromatic scaffolds. Using AthePKS, we designed an artificial enzymatic cascade towards an antimicrobial quinolone from a simple precursor and implemented it in E ...
Nika Sokolova   +5 more
wiley   +1 more source

Syntheses of Acridones via Copper(II)-Mediated Relay Reactions from o‑Aminoacetophenones and Arylboronic Acids

open access: yes, 2018
The reaction of o-aminoacetophenones and arylboronic acids catalyzed by copper­(II) salts in the presence of pyridine under an O2 atmosphere provides a general and efficient one-pot preparation of biologically interesting acridones.
Zhiguo Zhang (147197)   +5 more
core   +1 more source

Degrees of Sulfonation: Mapping the Reactivity Landscape of Acridine and Acridone

open access: yesOrganics
Although sulfonated acridines and acridones are valuable scaffolds in diagnostics and materials science, to our best knowledge, there is no comprehensive study that addresses how the degree of sulfonation depends on reaction parameters. To fill this gap,
Péter Kisfaludi   +3 more
doaj   +1 more source

Insertion of Benzene Rings into the Amide Bond: One-Step Synthesis of Acridines and Acridones from Aryl Amides

open access: yes, 2016
Insertion of benzene rings into the amide bond using the reactive intermediate benzyne is described. Aromatic amides undergo smooth insertion when treated with O-triflatophenyl silane benzyne precursors, producing versatile aminobenzophenone products in ...
Didier G. Pintori (2151043)   +1 more
core   +2 more sources

A Review of Anticancer Properties and Phytochemicals from Xao tam phan ( (Oliv.) Guillaum)

open access: yesNatural Product Communications
Paramignya trimera ( P. trimera (Oliv.) Guillaum), a Vietnamese plant has showed potential anticancer activities. Extracts from the plant's roots, stems, and leaves have shown cytotoxicity against a variety of cancer cell lines.
Pham Nguyen Bao Tran   +6 more
doaj   +1 more source

Alkylation of Acridone and Thioacridone

open access: yes, 1987
Department of Chemistry, University of Kalyani, Kalyani-741 235 Manuscript received 8 October 1986, accepted 22 April 1987 Alkylation of Acridone and Thioacridone.
S. K. CHATTOPADHYA   +2 more
openaire   +1 more source

Acridone alkaloids. X. 13C-Nuclear magnetic resonance spectra of acridone alkaloids.

open access: yesChemical and Pharmaceutical Bulletin, 1983
The 13C-nuclear magnetic resonance spectra of twenty-seven acridone alkaloids including angular pyrano [2, 3-c] acridones and linear pyrano [3, 2-b] acridones have been analyzed and assigned. The information should be useful for the structure elucidation of new acridone alkaloids.
FURUKAWA, HIROSHI   +2 more
openaire   +2 more sources

Shaping the Afterglow of Indolo[3, 2‐b]Carbazoles via Modulating Intersystem Crossing (ISC/rISC) and Phosphorescence Rates

open access: yesAggregate, Volume 7, Issue 4, April 2026.
In a series of indolo[3,2‐b]carbazoles (X‐ICZ‐p1; X = F, Cl, Br), the afterglow properties are shaped by modulating intersystem crossing (ISC/rISC) and phosphorescence rates. F/Cl‐ICZ‐p1 systems show moderate rates, achieving color‐tunable, dual‐mode afterglow in polymethyl methacrylate from persistent thermally activated delayed fluorescence (pTADF ...
Jiang Zhao   +4 more
wiley   +1 more source

Design, Synthesis, and Evaluation of 10-N-Substituted Acridones as Novel Chemosensitizers in Plasmodium falciparum

open access: yes, 2007
A series of novel 10-N-substituted acridones, bearing alkyl side chains with tertiary amine groups at the terminal position, were designed, synthesized, and evaluated for the ability to enhance the potency of quinoline drugs against multidrug-resistant ...
M. J. Smilkstein   +19 more
core   +1 more source

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