Results 21 to 30 of about 352 (121)

Functionalization of 4-bromobenzo[c][2,7]naphthyridine via regioselective direct ring metalation. A novel approach to analogues of pyridoacridine alkaloids

Beilstein Journal of Organic Chemistry, 2019
Readily available 4-bromobenzo[c][2,7]naphthyridine undergoes regioselective direct ring metalation at C-5 with TMPMgCl∙LiCl at −40 °C. Quenching with various electrophiles gives a broad range of 5-substituted products, which are building blocks for the ...
Benedikt C. Melzer, Alois Plodek, Franz Bracher   +2 more
doaj   +1 more source

A Metallosupramolecular Receptor for Squaraine Dyes Enabling Ultrafast Dark Resonance Energy Transfer

Angewandte Chemie, Volume 138, Issue 11, 9 March 2026.
A metallosupramolecular receptor binds squaraine dyes with high affinity and enables efficient dark resonance energy transfer (DRET) that generates bright near‐infrared emission with large pseudo‐Stokes shifts. ABSTRACT A metal‐organic cage was obtained by combining acridone‐based dipyridyl ligands with Pd2+ ions. The cage acts as a potent receptor for
Damien W. Chen, Tejas Deshpande, Sybille Collignon, Farzaneh Fadaei‐Tirani, Sascha Feldmann, Kay Severin   +5 more
wiley   +2 more sources

Acridone alkaloids. X. 13C-Nuclear magnetic resonance spectra of acridone alkaloids.

Chemical and Pharmaceutical Bulletin, 1983
The 13C-nuclear magnetic resonance spectra of twenty-seven acridone alkaloids including angular pyrano [2, 3-c] acridones and linear pyrano [3, 2-b] acridones have been analyzed and assigned. The information should be useful for the structure elucidation of new acridone alkaloids.
HIROSHI FURUKAWA, MOTOI YOGO, TIANSHUNG WU   +2 more
openaire   +2 more sources

Chemical Metabolomics: Chemical Biology Tools for Advanced Metabolism Investigations

Angewandte Chemie International Edition, EarlyView.
The human metabolism has been investigated for several millennia. The metabolome is known for a high complexity due to a large number of different metabolites that are present at different concentrations. Metabolomics has been developed as a field to investigate the entire human metabolome and to elucidate disease development mechanisms.
Alejandro Torregrosa‐Chinillach, Ioanna Tsiara, Wawrzyniec Haberek, Weifeng Lin, Daniel Globisch   +4 more
wiley   +1 more source

Theoretical Design of Acridone-Core Energetic Materials: Assessment of Detonation Properties and Potential as Insensitive, Thermally Stable High-Energy Materials

ChemEngineering
In this study, we investigated the impact of incorporating energetic substituents such as –NO2, –NH2, –Cl, –F, N-methyl-N-nitro (CH3–N–NO2), and picryl on the detonation performance and stability of acridone-based compounds.
Jelena Tamuliene, Jonas Sarlauskas
doaj   +1 more source

Boron Neutron Capture Therapy at a Crossroads: Translational Gap and Emerging Delivery Agents

Chemistry – A European Journal, EarlyView.
This review surveys recent advances in boron delivery agents for BNCT, emphasizing the shift from classical small molecules to multifunctional nanocarriers and theranostic systems. By integrating targeting, imaging, and therapy, next‐generation boron compounds aim to bridge the gap between (bio)chemical innovation and clinical translation.
Christoph Selg, Evamarie Hey‐Hawkins
wiley   +1 more source

Enzymatic synthesis of bioactive quinolones and (thio)coumarins by fungal type III polyketide synthases

The FEBS Journal, EarlyView.
Quinolones are valuable scaffolds for drug discovery but are rare in nature. Here, we show that two fungal enzymes, AthePKS and FerePKS, can generate 2‐quinolones and two additional heteroaromatic scaffolds. Using AthePKS, we designed an artificial enzymatic cascade towards an antimicrobial quinolone from a simple precursor and implemented it in E ...
Nika Sokolova, Angelina Osipyan, Lili Zhang, Matthew R. Groves, Sandy Schmidt, Kristina Haslinger   +5 more
wiley   +1 more source

Development of Mild Palladium‐Catalyzed N‐Arylation of Ortho‐Acylanilines in Rhamnolipid Micellar System

ChemSusChem, Volume 19, Issue 7, 14 April 2026.
Aqueous micellar catalysis using industrially sourced rhamnolipids enables efficient Pd‐catalyzed N‐arylation of o‐acylanilines at 40°C. This surfactant‐driven system offers a sustainable and more efficient alternative to organic solvents, combining broad substrate scope, low catalyst loading, and enhanced energy efficiency.
Attila R. Herczegh, Péter R. Kollár, Johannes Lehmann, Zoltán Novák   +3 more
wiley   +1 more source

Shaping the Afterglow of Indolo[3, 2‐b]Carbazoles via Modulating Intersystem Crossing (ISC/rISC) and Phosphorescence Rates

Aggregate, Volume 7, Issue 4, April 2026.
In a series of indolo[3,2‐b]carbazoles (X‐ICZ‐p1; X = F, Cl, Br), the afterglow properties are shaped by modulating intersystem crossing (ISC/rISC) and phosphorescence rates. F/Cl‐ICZ‐p1 systems show moderate rates, achieving color‐tunable, dual‐mode afterglow in polymethyl methacrylate from persistent thermally activated delayed fluorescence (pTADF ...
Jiang Zhao, Lihua Xu, Ye Meng, Bingjia Xu, Hang Cong   +4 more
wiley   +1 more source

Unravelling the Functional Diversity of Type III Polyketide Synthases in Fungi

Angewandte Chemie, Volume 137, Issue 44, October 27, 2025.
Type III polyketide synthases (T3PKSs) produce diverse compounds of ecological and clinical importance. Here, the activity of 37 fungal T3PKSs was profiled, revealing unexpected products and generating several pharmaceutical precursors. The machine learning model trained on the activity data accurately extrapolates the predictions to other enzymes and ...
Nika Sokolova, Stepan S. Denisov, Thomas Hackl, Kristina Haslinger   +3 more
wiley   +2 more sources