Coupled Excited-State Dynamics in N-Substituted 2-Methoxy-9-Acridones [PDF]
Frontiers in Chemistry, 2019 Fluorophores of the acridone family have been widely employed in many applications, such as DNA sequencing, the detection of biomolecules, and the monitoring of enzymatic systems, as well as being the bases of intracellular sensors and even antitumoral ...
M. Carmen Gonzalez-Garcia +9 more
doaj +4 more sources
‘Acridines’ as New Horizons in Antifungal Treatment [PDF]
Molecules, 2020 Frequent fungal infections in immunocompromised patients and mortality due to invasive mycosis are important clinical problems. Opportunistic pathogenic Candida species remain one of the leading causes of systemic mycosis worldwide.
Iwona Gabriel
doaj +2 more sources
Evaluating acridones as novel therapeutics for human babesiosis. [PDF]
Antimicrob Agents ChemotherABSTRACT Human babesiosis is an emerging tick-borne disease caused by Babesia parasites, most notably Babesia microti and Babesia duncani ...
Vydyam P +6 more
europepmc +4 more sources
Assessment of DNA Topoisomerase I Unwinding Activity, Radical Scavenging Capacity, and Inhibition of Breast Cancer Cell Viability of N-alkyl-acridones and N,N′-dialkyl-9,9′-biacridylidenes [PDF]
Biomolecules, 2019 The anticancer activity of acridone derivatives has attracted increasing interest, therefore, a variety of substituted analogs belonging to this family have been developed and evaluated for their anti-cancer properties.
Marios G. Krokidis +9 more
doaj +2 more sources
Antiprotozoal Activity and DNA Binding of Dicationic Acridones [PDF]
Journal of Medicinal Chemistry, 2015 Dicationic acridone derivatives were synthesized and their antiparasitic activity was evaluated. Acridones displayed in vitro nanomolar IC50 values against Trypanosoma brucei rhodesiense STIB900 with selectivity indices >1000. Compounds 1b, 3a, and 3b were as potent as the reference drug melarsoprol in this assay.
Montalvo-Quirós, Sandra +3 more
openaire +6 more sources
Acridones Are Highly Potent Inhibitors of Toxoplasma gondii Tachyzoites. [PDF]
ACS Infect Dis, 2021 Acridone derivatives, which have been shown to have and activity against spp, inhibit proliferation at picomolar concentrations. Using enzymatic assays, we show that acridones inhibit both cytochrome and dihydroorotate dehydrogenase and identify ...
Alday PH +6 more
europepmc +2 more sources
Synthesis, Structural Modification, and Bioactivity Evaluation of Substituted Acridones as Potent Microtubule Affinity-Regulating Kinase 4 Inhibitors [PDF]
ACS Pharmacology and Translational Science, 2023 Maria Voura +2 more
exaly +2 more sources
Lead Optimization of Second-Generation Acridones as Broad-Spectrum Antimalarials. [PDF]
J Med Chem, 2020 The global impact of malaria remains staggering despite extensive efforts to eradicate the disease. With increasing drug resistance and the absence of a clinically available vaccine, there is an urgent need for novel, affordable, and safe drugs for ...
Kancharla P +41 more
europepmc +3 more sources
Electron‐Poor Acridones and Acridiniums as Super Photooxidants in Molecular Photoelectrochemistry by Unusual Mechanisms [PDF]
, 2023 Electron-deficient acridones and in situ generated acridinium salts are reported as potent, closed-shell photooxidants that undergo surprising mechanisms.
Domański, Michał +7 more
core +7 more sources
Boron Trifluoride Etherate Promoted Microwave-Assisted Synthesis of Antimalarial Acridones. [PDF]
RSC Adv, 2019 A microwave-assisted, rapid and efficient method using boron trifluoride etherate (BF3.Et2O) for the synthesis of acridones, via an intramolecular acylation of N-phenylanthranilic acid derivatives, has been developed.
Kancharla P, Dodean RA, Li Y, Kelly JX.
europepmc +2 more sources