Results 11 to 20 of about 664 (168)

Electron‐Poor Acridones and Acridiniums as Super Photooxidants in Molecular Photoelectrochemistry by Unusual Mechanisms [PDF]

, 2023
Electron-deficient acridones and in situ generated acridinium salts are reported potent, closed-shell photooxidants that undergo surprising mechanisms.
Jonas Žurauskas, Schmid, Simon, Tomáš Slanina, Wu, Shangze, Butera, Valeria, Shangze Wu, Domański, Michał, Barham, Joshua Philip, Valeria Butera, Joshua P. Barham, Boháčová, Soňa, Michał Domański, Žurauskas, Jonas, Simon Schmid, Slanina, Tomáš, Soňa Boháčová   +15 more
core   +11 more sources

Synthesis of acridone derivatives via heterologous expression of a plant type III polyketide synthase in Escherichia coli [PDF]

Microbial Cell Factories, 2020
Background Acridone alkaloids are heterocyclic compounds that exhibit a broad-range of pharmaceutical and chemotherapeutic activities, including anticancer, antiviral, anti-inflammatory, antimalarial, and antimicrobial effects. Certain plant species such
Gyu-Sik Choi, Hye Jeong Choo, Bong-Gyu Kim, Joong-Hoon Ahn   +3 more
doaj   +2 more sources

Synthesis and Biological Evaluation of Acridone Derivatives for Antimicrobial and Antifungal Applications [PDF]

Journal of Experimental Pharmacology
Ali Salman Al-Shami,1,2 Jalal Alkadsi3 1Department of Pharmacology, Faculty of Medicine, Sanaa University, Sanaa City, Republic of Yemen; 2Jiblah University for Medical and Health Science, Ibb City, Republic of Yemen; 3Department of Medicinal Chemistry ...
Al-Shami AS, Alkadsi J
doaj   +2 more sources

Assessment of DNA Topoisomerase I Unwinding Activity, Radical Scavenging Capacity, and Inhibition of Breast Cancer Cell Viability of N-alkyl-acridones and N,N′-dialkyl-9,9′-biacridylidenes [PDF]

Biomolecules, 2019
The anticancer activity of acridone derivatives has attracted increasing interest, therefore, a variety of substituted analogs belonging to this family have been developed and evaluated for their anti-cancer properties.
Marios G. Krokidis, Zara Molphy, Eleni K. Efthimiadou, Marianna Kokoli, Smaragda-Maria Argyri, Irini Dousi, Annalisa Masi, Kyriakos Papadopoulos, Andrew Kellett, Chryssostomos Chatgilialoglu   +9 more
doaj   +2 more sources

Acridones Are Highly Potent Inhibitors of Toxoplasma gondii Tachyzoites. [PDF]

ACS Infect Dis, 2021
Acridone derivatives, which have been shown to have and activity against spp, inhibit proliferation at picomolar concentrations. Using enzymatic assays, we show that acridones inhibit both cytochrome and dihydroorotate dehydrogenase and identify ...
Alday PH, McConnell EV, Boitz Zarella JM, Dodean RA, Kancharla P, Kelly JX, Doggett JS.   +6 more
europepmc   +2 more sources

N-Aryl Acridone Derivatives as Effective Catalysts for Energy Transfer Reactions. [PDF]

Chemistry
Acridones derivatives have high triplet energy, are simple accessible, and could be used in challenging [2+2] ENT reactions. ABSTRACT Organic photocatalysts capable of promoting high‐energy triplet energy transfer (EnT) remain limited, particularly for demanding [2+2] photocycloaddition reactions.
Calogero F, D'Onghia G, Fina F, Ziani Z, Sensoli L, Gualandi A, Fermi A, Ceroni P, Cozzi PG.   +8 more
europepmc   +2 more sources

Boron Trifluoride Etherate Promoted Microwave-Assisted Synthesis of Antimalarial Acridones. [PDF]

RSC Adv, 2019
A microwave-assisted, rapid and efficient method using boron trifluoride etherate (BF3.Et2O) for the synthesis of acridones, via an intramolecular acylation of N-phenylanthranilic acid derivatives, has been developed.
Kancharla P, Dodean RA, Li Y, Kelly JX.
europepmc   +2 more sources

Stereoretentive Nucleophilic Aromatic Substitution Accesses Atropisomeric 4-Amino-N-Arylquinolinium Salts. [PDF]

Chemistry
Quinolin‐4‐ones were converted to chloroquinolinium salts, allowing formation of axially chiral aminoquinolinium salts via an enantioretentive SNAr reaction with a variety of amine nucleophiles. The salts have a high rotational barrier, with a racemization half‐life of ∼1000s of years.
Holmes D, Foster N, Ansari S, Kavanagh P, Dingwall P, Knipe PC.   +5 more
europepmc   +2 more sources

Lead Optimization of Second-Generation Acridones as Broad-Spectrum Antimalarials. [PDF]

J Med Chem, 2020
The global impact of malaria remains staggering despite extensive efforts to eradicate the disease. With increasing drug resistance and the absence of a clinically available vaccine, there is an urgent need for novel, affordable, and safe drugs for ...
Kancharla P, Dodean RA, Li Y, Pou S, Pybus B, Melendez V, Read L, Bane CE, Vesely B, Kreishman-Deitrick M, Black C, Li Q, Sciotti RJ, Olmeda R, Luong TL, Gaona H, Potter B, Sousa J, Marcsisin S, Caridha D, Xie L, Vuong C, Zeng Q, Zhang J, Zhang P, Lin H, Butler K, Roncal N, Gaynor-Ohnstad L, Leed SE, Nolan C, Ceja FG, Rasmussen SA, Tumwebaze PK, Rosenthal PJ, Mu J, Bayles BR, Cooper RA, Reynolds KA, Smilkstein MJ, Riscoe MK, Kelly JX.   +41 more
europepmc   +3 more sources

New Acridone- and (Thio)Xanthone-Derived 1,1-Donor–Acceptor-Substituted Alkenes: pH-Dependent Fluorescence and Unusual Photooxygenation Properties

Molecules, 2021
A synthetic route to new heterocyclic 1,1-donor–acceptor-substituted alkenes starting with N-methyl-acridone, xanthone, and thioxanthone was investigated, leading to the acridone- and xanthone-derived products methyl 2-methoxy-2-(10-methylacridin-9 (10H)-
Tim Lippold, Jörg M. Neudörfl, Axel Griesbeck   +2 more
doaj   +1 more source