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Human Molecular Genetics, 2021 Abstract Asthenoteratospermia is a common cause of male infertility. Recent studies have revealed that CFAP65 mutations lead to severe asthenoteratospermia due to acrosome hypoplasia and flagellum malformations. However, the molecular mechanism underlying CFAP65-associated sperm malformation is largely unclear.
Qianjun Zhang, Juan Du, Liqing Fan
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Equatorin is not essential for acrosome biogenesis but is required for the acrosome reaction
Biochemical and Biophysical Research Communications, 2014The acrosome is a specialized organelle that covers the anterior part of the sperm nucleus and plays an essential role in mammalian fertilization. However, the regulatory mechanisms controlling acrosome biogenesis and acrosome exocytosis during fertilization are largely unknown.
Min Chen, Xingxu Huang, Yaqing Wang
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Acrosome biogenesis begins during meiosis: evidence from the synthesis and distribution of an acrosomal glycoprotein, acrogranin, during guinea pig spermatogenesis [PDF]
Biology of Reproduction, 1990 The biogenesis of the sperm-specific organelle, the acrosome, was investigated using an acrosomal glycoprotein as a marker of development. This component, which we have named acrogranin, was purified from an acid extract of guinea pig testes by standard chromatographic procedures.
George L Gerton
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Sirt1 regulates acrosome biogenesis by modulating autophagic flux during spermiogenesis in mice [PDF]
Development (Cambridge), 2017 ABSTRACT Sirt1 is a member of the sirtuin family of proteins and has important roles in numerous biological processes. Sirt1−/− mice display an increased frequency of abnormal spermatozoa, but the mechanism of Sirt1 in spermiogenesis remains largely unknown.
Chao Liu, Fengyi Gao, Jianwei Jiao
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Human globozoospermia‐related genes and their role in acrosome biogenesis
WIREs Mechanisms of Disease, 2022AbstractThe mammalian acrosome is a secretory vesicle attached to the sperm nucleus whose fusion with the overlying plasma membrane is required to achieve fertilization. Acrosome biogenesis starts during meiosis, but it lasts through the entire process of haploid cell differentiation (spermiogenesis).
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Sperm acrosome biogenesis and function during fertilization
2016Over the last decades, acrosomal exocytosis (also called the “acrosome reaction”) has been recognized as playing an essential role in fertilization. Secretion of this granule is an absolute requirement for physiological fertilization. In recent years, the study of mammalian acrosomal exocytosis has yielded some major advances that challenge the long ...
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The Slingshot phosphatase 2 is required for acrosome biogenesis during spermatogenesis in mice
2022Abstract The acrosome is a membranous organelle positioned in the anterior portion of sperm head and is essential for male fertility. Acrosome biogenesis requires the dynamic cytoskeletal shuttling of vesicles towards nascent acrosome which is regulated by a series of accessory proteins.
Ke Xu +8 more
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RAB2A: a major subacrosomal protein of bovine spermatozoa implicated in acrosomal biogenesis.
Biology of reproduction, 2008The perinuclear theca (PT) of mammalian sperm is a unique subcellular structure encapsulating the nucleus. Compositionally, the PT is made up of at least six prominent polypeptides (60, 36, 31, 28, 24, and 15 kDa), of which only two have been sequence identified, as well as many less prominent ones.
Jeremi R, Mountjoy +4 more
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European Journal of Cell Biology, 2009 The N-terminal BAR domain of endophilin has unique functions, such as affecting the curvature of the lipid membrane through its lysophosphatidic acid acyltransferase activity, binding of ATP and GTP and participating in tubulating activity. We recently demonstrated that SH3P13, a BAR domain-containing protein, assists in regulating clathrin-coated ...
Shuchun, Li +11 more
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