Results 61 to 70 of about 2,979 (146)

The influence of ACSS2 knockdown on the proliferation, apoptosis and migration of NSCLC cell line A549

Zhongguo aizheng zazhi, 2016
Background and purpose: Metabolism change is one of the main characteristics of the tumor development. Many studies have confirmed that cytosolic acetyl-CoA synthetase 2 (ACSS2) plays a critical role in hydrocarbon metabolism of cancer cells.
卢晓霞, 常　淑, 毕明宏
doaj  

POU2F1 Promotes Chemoresistance in Colorectal Cancer Cells via Attenuates the MDR2 Degradation Mediated by PPP1R11 Lactylation

Advanced Science, Volume 13, Issue 28, 18 May 2026.
Schematic diagram of our study showing that highly expressed POU2F1 in colorectal cancer (CRC) can directly accelerate the cytosolic lactate export to decrease PPP1R11 lactylation at K59, thereby attenuating the E3 ligase enzyme activity and protein stability of PPP1R11, which inhibits the ubiquitination of MDR2 at K413 and K538 but increases the ...
Longzheng Xia, Jinguan Lin, Xianjie Jiang, Linda Oyang, Shiming Tan, Zongyao Ren, Qiu Peng, Qianjin Liao, Yujuan Zhou   +8 more
wiley   +1 more source

Acetyl-CoA synthetase 2 induces pyroptosis and inflammation of renal epithelial tubular cells in sepsis-induced acute kidney injury by upregulating the KLF5/NF-κB pathway

Cell Communication and Signaling
Background Pyroptosis of the renal tubular epithelial cells (RTECs) and interstitial inflammation are central pathological characteristics of acute kidney injury (AKI).
Jian Lu, Ya Hou, Si-Xiu Liu, Bo Jin, Jing Liu, Nan Li, Yan Zhu, Qing-Yan Zhang, Cheng Wan, Yuan Feng, Jun Xie, Chun-Ming Jiang   +11 more
doaj   +1 more source

Exercise and Skeletal Muscle‐Derived Extracellular Vesicles: Their Cargo, Release, and Role in Metabolic Regulation

Journal of Extracellular Biology, Volume 5, Issue 5, May 2026.
ABSTRACT The health benefits of exercise are well established in the prevention and management of metabolic disorders such as obesity and diabetes. Emerging evidence indicates that extracellular vesicles (EVs) may contribute to the beneficial effects of exercise.
Jeremy Boulestreau, Scott K. Ferguson, Luke Nelson, Noemi Polgar   +3 more
wiley   +1 more source

ACSS2 controls PPARγ activity homeostasis to potentiate adipose-tissue plasticity

Cell Death & Differentiation
AbstractThe appropriate transcriptional activity of PPARγ is indispensable for controlling inflammation, tumor and obesity. Therefore, the identification of key switch that couples PPARγ activation with degradation to sustain its activity homeostasis is extremely important. Unexpectedly, we here show that acetyl-CoA synthetase short-chain family member
Nuo Chen, Ming Zhao, Nan Wu, Yaxin Guo, Baihui Cao, Bing Zhan, Yubin Li, Tian Zhou, Faliang Zhu, Chun Guo, Yongyu Shi, Qun Wang, Yan Li, Lining Zhang   +13 more
openaire   +2 more sources

Histone Modifications in Cardiovascular Disease: Mechanisms and Therapeutic Opportunities

MedComm, Volume 7, Issue 5, May 2026.
This graphical abstract summarizes how classical and emerging histone posttranslational modifications (PTMs), together with their chromatin regulators (writers, erasers, and readers), govern major pathobiological programs in cardiovascular disease.
Yu Zheng, Yu‐Xuan Gao, Mei‐Xing Guo, Li‐Ting Wang, Xiao‐Wen Zheng, Yi‐Hao Liao, Ya Li, Jun‐Ping Zhu, Jia‐Ming Wei   +8 more
wiley   +1 more source

ACSS2-mediated acetyl-CoA synthesis from acetate is necessary for human cytomegalovirus infection [PDF]

Proceedings of the National Academy of Sciences, 2017
Significance Viruses rely completely on host cell metabolism to provide the building blocks and energy required for producing progeny virions. Infection by human cytomegalovirus (HCMV) induces significant alterations in glucose metabolism by increasing glucose uptake and glycolysis as well as redirecting glucose carbon to support the ...
Anna Vysochan, Arjun Sengupta, Aalim M. Weljie, James C. Alwine, Yongjun Yu   +4 more
openaire   +2 more sources

ACSS2 drives senescence-associated secretory phenotype by limiting purine biosynthesis through PAICS acetylation

Nature Communications
Senescence-associated secretory phenotype (SASP) mediates the biological effects of senescent cells on the tissue microenvironment and contributes to ageing-associated disease progression.
Li Yang, Jianwei You, Xincheng Yang, Ruishu Jiao, Jie Xu, Yue zhang, Wen Mi, Lingzhi Zhu, Youqiong Ye, Ruobing Ren, Delin Min, Meilin Tang, Li Chen, Fuming Li, Pingyu Liu   +14 more
doaj   +1 more source

Interleukin‐10 Derived Apoptotic Vesicles Enhance Scarless Skin Healing by Modulating Fibroblast Metabolism and Fibrosis Pathways

Cell Proliferation, Volume 59, Issue 5, May 2026.
IL10_ApoEVs, generated during IL‐10‐induced fibroblast apoptosis, reprogram fibroblast metabolism and inhibit fibrosis to promote scarless skin healing. By enhancing mitochondrial OXPHOS, suppressing glycolysis, and downregulating Hedgehog signaling, IL10_ApoEVs shift collagen deposition toward regenerative type III collagen, offering a novel strategy ...
Yang Zou, Jinglun Zhang, Wenxuan Mao, Shuting Jiang, Cheng Xu, Jiayi Meng, Heng Dong, Yongbin Mou   +7 more
wiley   +1 more source

Cancer‐Associated Fibroblasts Functions as Multifunctional Architects of the Tumor Stroma and Represent Emerging Therapeutic Vulnerabilities

Advanced Science, Volume 13, Issue 24, 27 April 2026.
ABSTRACT Cancer‐associated fibroblasts (CAFs) are the predominant stromal components within the tumor microenvironment (TME), playing multifaceted roles in cancer progression through dynamic interactions with neoplastic and immune cells. Emerging evidence has revealed remarkable heterogeneity and plasticity of CAFs, which originate from diverse ...
Rujiao Liu, Lili Su, Shuiping Gao, Wenting Liu, Hongxia Wang   +4 more
wiley   +1 more source