Results 71 to 80 of about 2,979 (146)

Interwoven control of histone lactylation: metabolic enzymes LDHA/ACSS2 couple with epigenetic writer KAT2A

Visualized Cancer Medicine
Histone lactylation is critically involved in the regulation of gene expression and the modulation of diverse cellular processes in both normal and tumor cells. A recent study by Zhu et al. [Cell Metab. 37, 361–376] demonstrated that ACSS2 functions as a
Zhu Rongxuan, Li Yuan, Zhao Hong, Meng Ying, Guo Dong, Han Hongkuan, Lu Zhimin   +6 more
doaj   +1 more source

Brain Short-Chain Fatty Acids Induce ACSS2 to Ameliorate Depressive-Like Behavior via PPARγ–TPH2 Axis

Research
Short-chain fatty acids (SCFAs) have been increasingly evidenced to be important bioactive metabolites of the gut microbiota and transducers in controlling diverse psychiatric or neurological disorders via the microbiota–gut–brain axis.
Nuo Chen, Xinyi Xu, Yaxin Guo, Ming Zhao, Yubin Li, Tian Zhou, Xinyue Zhang, Jie Gao, Faliang Zhu, Chun Guo, Yongyu Shi, Qun Wang, Wenxian Wu, Lining Zhang, Yan Li   +14 more
doaj   +1 more source

Epigenetic mechanisms and therapeutic innovations in chronic pain‐associated neuropsychiatric co‐morbidities

British Journal of Pharmacology, Volume 183, Issue 7, Page 1313-1340, April 2026.
Abstract Chronic pain, marked by nociceptive sensitization and maladaptive neuroplasticity, affects 30% of the global population with escalating socioeconomic burdens. Epidemiological data show a 2‐3‐fold increase in neuropsychiatric co‐morbidities among individuals with chronic pain, where epigenetic dysregulation serves as a key mechanism linking ...
Kai Zhang, Sijia Zhu, Na Xing, Zhen Zhou, Jiayi Chen, Tianen Si, Mingrui Li, Lin Jia, Yousef Rastegar‐Kashkooli, Tom J. Wang, Wei Zhu, Jing Li, Chao Jiang, Junmin Wang, Moxin Wu, Xiaoping Yin, Weidong Zang, Jian Wang, Songxue Su   +18 more
wiley   +1 more source

Acetate Revisited: A Key Biomolecule at the Nexus of Metabolism, Epigenetics, and Oncogenesis – Part 2: Acetate and ACSS2 in Health and Disease

Frontiers in Physiology, 2020
Acetate, the shortest chain fatty acid, has been implicated in providing health benefits whether it is derived from the diet or is generated from microbial fermentation of fiber in the gut.
John R. Moffett, Narayanan Puthillathu, Ranjini Vengilote, Diane M. Jaworski, Aryan M. Namboodiri   +4 more
doaj   +1 more source

Novel Substituted Tetrazoles as ACSS2 Inhibitors for Treating Cancer [PDF]

ACS Medicinal Chemistry Letters, 2021
openaire   +2 more sources

Acetyl-CoA synthetase (ACSS2) does not generate butyryl- and crotonyl-CoA

Molecular Metabolism
Acetyl and other acyl groups from different short-chain fatty acids (SCFA) competitively modify histones at various lysine sites. To fully understand the functional significance of such histone acylation, a key epigenetic mechanism, it is crucial to characterize the cellular sources of the corresponding acyl-CoA molecules required for the lysine ...
Zeaiter, Nour, Belot, Laura, Cunin, Valérie, Nahed, Roland Abi, Tokarska-Schlattner, Malgorzata, Le Gouellec, Audrey, Petosa, Carlo, Khochbin, Saadi, Schlattner, Uwe   +8 more
openaire   +4 more sources

The acetate/ACSS2 switch regulates HIF-2 stress signaling in the tumor cell microenvironment.

PLoS ONE, 2015
Optimal stress signaling by Hypoxia Inducible Factor 2 (HIF-2) during low oxygen states or hypoxia requires coupled actions of a specific coactivator/lysine acetyltransferase, Creb binding protein (CBP), and a specific deacetylase, Sirtuin 1 (SIRT1).
Rui Chen, Min Xu, Jason S Nagati, Richard T Hogg, Alok Das, Robert D Gerard, Joseph A Garcia   +6 more
doaj   +1 more source

KRAS mutation-selective requirement for ACSS2 in colorectal adenoma formation.

Abstract Oncogenic KRAS mutations are prevalent in colorectal cancer (CRC) and are associated with poor prognosis and resistance to therapy. There is a substantial diversity of KRAS mutant alleles observed in CRC. Emerging clinical and experimental analysis of common KRAS mutations suggest that each mutation differently influences the clinical ...
Jonathan Chernoff, Konstantin Budagyan, Alexa Cannon, Adam Chatoff, Nathaniel Snyder, Alison Kurimchak, James Duncan   +6 more
openaire   +2 more sources

Acetylome Analyses Provide New Insights Into the Effects of Childhood Allergic Rhinitis on Olfactory Bulb‐Dependent Olfactory Impairment

Allergy, Volume 81, Issue 5, Page 1891-1894, May 2026.
Ruikun Wang, Ziying Xu, Yimin Zhang, Qian Wang, Mengyao Li, Jieqiong Liang, Xiaojun Zhan, YinXia Lu, Jing Yuan, Shan Wang, Qinglong Gu   +10 more
wiley   +1 more source

Proteomic profiling reveals ACSS2 facilitating metabolic support in acute myeloid leukemia

Cancer Gene Therapy
AbstractAcute myeloid leukemia (AML) is a heterogeneous disease characterized by genomic aberrations in oncogenes, cytogenetic abnormalities, and an aberrant epigenetic landscape. Nearly 50% of AML cases will relapse with current treatment. A major source of therapy resistance is the interaction of mesenchymal stroma with leukemic cells resulting in ...
Liliana H. Mochmann, Denise Treue, Michael Bockmayr, Patricia Silva, Christin Zasada, Guido Mastrobuoni, Safak Bayram, Martin Forbes, Philipp Jurmeister, Sven Liebig, Olga Blau, Konstanze Schleich, Bianca Splettstoesser, Thierry M. Nordmann, Eva K. von der Heide, Konstandina Isaakidis, Veronika Schulze, Caroline Busch, Hafsa Siddiq, Cornelia Schlee, Svenja Hester, Lars Fransecky, Martin Neumann, Stefan Kempa, Frederick Klauschen, Claudia D. Baldus   +25 more
openaire   +5 more sources