Results 161 to 170 of about 1,498,374 (404)

Homologous expression and purification of human HAX‐1 for structural studies

FEBS Open Bio, EarlyView.
This research protocol provides detailed instructions for cloning, expressing, and purifying large quantities of the intrinsically disordered human HAX‐1 protein, N‐terminally fused to a cleavable superfolder GFP, from mammalian cells. HAX‐1 is predicted to undergo posttranslational modifications and to interact with membranes, various cellular ...
Mariana Grieben
wiley   +1 more source

Synthesis of Small Molecule Derivatives of CK-666 as Potential Inhibitors of the Arp2/3 Complex [PDF]

, 2019
The Actin-Related Protein (Arp) 2/3 Complex is an actin nucleating factor intrinsically involved in cellular regulation of actin networks during life-essential processes such as motility.
Baggett, Andrew W., Nolen, Brad J., Sripeng, Atchara, Wade, Natalie   +3 more
core   +1 more source

Bin1 directly remodels actin dynamics through its BAR domain [PDF]

, 2017
Nina M. Dräger, Eliana Nachman, Moritz Winterhoff, Stefan Brühmann, Pranav N. M. Shah, Panagiotis Katsinelos, Steeve Boulant, Aurelio A. Teleman, Jan Faix, Thomas R. Jahn   +9 more
openalex   +1 more source

Molecular determinants of signal transduction in tropomyosin receptor kinases

FEBS Open Bio, EarlyView.
Tropomyosin receptor kinases control critical neuronal functions, but how do the same receptors produce diverse cellular responses? This review explores the structural mechanisms behind Trk signaling diversity, focusing on allosteric modulation and ligand bias.
Giray Enkavi
wiley   +1 more source

Single-Particle Tracking Demonstrates that Actin Coordinates the Movement of the Ebola Virus Matrix Protein [PDF]

, 2012
Emmanuel Adu‐Gyamfi, Michelle A. Digman, Enrico Gratton, Robert V. Stahelin   +3 more
openalex   +1 more source

ATG4B is required for mTORC1‐mediated anabolic activity and is associated with clinical outcomes in non‐small cell lung cancer

FEBS Open Bio, EarlyView.
The relationship between anabolic and catabolic processes governing lung cancer cell growth is nuanced. We show that ATG4B, an autophagy regulator, is elevated in lung cancer and that high ATG4B is associated with worse patient outcomes. Targeting ATG4B in cells reduces growth, protein synthesis, and mTORC1 activity, demonstrating a new relationship ...
Patrick J. Ryan, Bethany C. Guerra, Selina Uranga, Jessica M. Cardin, Steven E. Riechman, Mariana Janini Gomes, James D. Fluckey   +6 more
wiley   +1 more source

Establishment of a coculture system for Porphyromonas gingivalis and head and neck squamous cell carcinoma using spheroid culture and LATS inhibition

FEBS Open Bio, EarlyView.
We established a spheroid coculture system enabling viable Porphyromonas gingivalis–HNSCC interactions under normoxic conditions. Inhibition of LATS1/2 maintains tumor cells in an undifferentiated state, which may promote spheroid growth and create a more permissive environment for bacterial persistence.
Yurika Nakajima, Shogo Okazaki, Muneaki Tamura, Shuichi Sato, Kenichi Imai   +4 more
wiley   +1 more source

Membrane Supply and Demand Regulates F-Actin in a Cell Surface Reservoir [PDF]

, 2016
Lauren Figard, Mengyu Wang, Liuliu Zheng, Ido Golding, Anna Marie Sokac   +4 more
openalex   +1 more source

In vivo interactions between myosin XI, vesicles and filamentous actin are fast and transient in Physcomitrella patens [PDF]

, 2020
Jeffrey P. Bibeau, Fabienne Furt, Sayed Iman Mousavi, James L. Kingsley, Max F. Levine, Erkan Tüzel, Luis Vidali   +6 more
openalex   +1 more source

Lifeact: a versatile marker to visualize F-actin

Nature Methods, 2008
J. Riedl, Á. Crevenna, K. Kessenbrock, J. Yu, Dorothee Neukirchen, M. Bista, F. Bradke, D. Jenne, T. Holak, Z. Werb, M. Sixt, R. Wedlich-Soldner   +11 more
semanticscholar   +1 more source