Results 231 to 240 of about 625,356 (301)

Intracellular complement Factor H promotes tumor progression through modulation of cell cycle and actin cytoskeleton. [PDF]

Commun Biol
Rezola Artero M, Minery A, Revel M, Armento A, Jarboui MA, Boudhabhay I, de Castro Deus M, Zarantonello A, Fleury E, Segarra L, Redissi A, Merle NS, Dragon-Durey MA, Monnot C, Sautes-Fridman C, Dimitrov JD, Fridman WH, Ueffing M, Roumenina LT.   +18 more
europepmc   +1 more source

FAK Mediated Coordination of Extracellular Matrix Remodeling and Cellular Mechanics Impairs Nanomedicine Delivery in Solid Tumors

Advanced Science, EarlyView.
FAK orchestrates a mechanical barrier limiting nanomedicine accumulation in solid tumors by coupling ECM remodeling with cytoskeletal tension. Genetic or pharmacological FAK inhibition dismantles this barrier, enhances clathrin‐mediated uptake and penetration, and overcomes delivery limitations to improve antitumor efficacy.
Tian Zhao, Hao Wu, Yujie Qin, Jingfei Zhu, Ye Huang, Wei Chen, Jiaxuan Yu, Xiang Qin, Shun Li, Junjie Li, Tingting Li, Yiyao Liu   +11 more
wiley   +1 more source

Annexin A2 stabilizes the endoplasmic reticulum and actin cytoskeleton and influences the formation of reovirus factories. [PDF]

J Virol
Tenorio R, Taylor GM, Cayuela A, Sorzano COS, Fernández de Castro I, Fernández-Sánchez SY, Roth AN, Somoulay X, Treadaway GS, Dermody TS, Risco C.   +10 more
europepmc   +1 more source

Regulation of MKL1 via actin cytoskeleton dynamics drives adipocyte differentiation

Nature Communications, 2014
Hiroyuki Nobusue, N. Onishi, T. Shimizu, E. Sugihara, Yoshinao Oki, Y. Sumikawa, T. Chiyoda, K. Akashi, H. Saya, K. Kano   +9 more
semanticscholar   +1 more source

3D Bioprinted Blood–Brain–Tumor Barrier Spheroid‐Based In Situ Evaluation of Anticancer Compounds Against Glioblastoma: ROS‐Producing Ruthenium as a Potential Therapeutic Candidate

Advanced Science, EarlyView.
The blood–brain–tumor barrier (BBTB) penetration by anticancer drugs and their effects on glioblastoma (GBM) is assessed using 3D bioprinted‐spheroids. Anticancer drug‐induced U‐87 MG cell death is quantified through in situ imaging of spheroids using a cancer cell death probe. The Ru compound, a partial P‐gp substrate, induces greater tumor‐cell death
Hyunjung Lee, Chan Ho Jeon, Doyun Kim, Minjae Lee, Minji Kwon, Joon Myong Song   +5 more
wiley   +1 more source

FSCN1 induces subchondral bone sclerosis in osteoarthritis via modulating actin cytoskeleton dynamics and YAP signaling. [PDF]

Arthritis Res Ther
Xiao Y, Chen L, Chen D, Li J, Cheng Q, Yang P, Zou Z, Wu J, Li K, Yang C, Wang H, Yang C.   +11 more
europepmc   +1 more source

β‐Adducin Restrains PLA2G4A‐Dependent Lysosomal Membrane Permeabilization and Neuronal Death in Ischemic Stroke

Advanced Science, EarlyView.
This study identifies β‐adducin as a regulator of lysosomal integrity in ischemic neurons. Ischemia‐associated FTO loss increases m6A modification and destabilizes Add2 mRNA, reducing β‐adducin expression and promoting PLA2G4A accumulation at lysosomes.
Hui‐qin Li, Pin‐yi Liu, Dan Wu, Fei‐yu Ma, Yi Bai, Sheng‐nan Xia, Hai‐yan Yang, Xin‐yu Bao, Yun Xu, Xiang Cao   +9 more
wiley   +1 more source

Rac1 promotes proximal tubule kidney repair by coupling the actin cytoskeleton to mitochondrial function. [PDF]

Proc Natl Acad Sci U S A
M Viquez O, Melzer M, Li S, Tantengco M, Dong X, Sha E, Huang J, Krystofiak ES, Hart RC, Luo W, Warren C, Bayazid AB, Zhang R, Bessho R, Haase VH, Brakebusch C, Inoue T, Brooks C, Wilson MH, Terker AS, Arroyo JP, Pozzi A, Zent R, Bock F.   +23 more
europepmc   +1 more source

Age‐Related Lamin B1 Deficiency Activates SLC7A11‐Dependent Disulfidptosis to Impair Osteogenesis via Intercepting Mitochondrial Fission

Advanced Science, EarlyView.
This study reveals that age‐related LMNB1 deficiency in mesenchymal stem cells epigenetically upregulates SLC7A11, triggering actin disulfidptosis and mitochondrial dysfunction. This cascade impairs bone formation in senile osteoporosis. Furthermore, researchers identified the FDA‐approved drug naldemedine as a targeted SLC7A11 inhibitor to reverse ...
Wenhui Yu, Qibo Li, Weihao Zhang, Guan Zheng, Junhua Chen, Yipeng Zeng, Zipeng Xiao, Zibin Chen, Ziqian Liu, Yangfeng Lin, Jiajie Lin, Zepeng Su, Zhongyu Xie   +12 more
wiley   +1 more source

[Corrigendum] Silencing of Rac1 modifies lung cancer cell migration, invasion and actin cytoskeleton rearrangements and enhances chemosensitivity to antitumor drugs. [PDF]

Int J Mol Med
Chen QY, Xu LQ, Jiao DM, Yao QH, Wang YY, Hu HZ, Wu YQ, Song J, Yan J, Wu LJ.   +9 more
europepmc   +1 more source