Results 241 to 250 of about 287,702 (305)

Antifibrotic effects of specific targeting of the 5‐hydroxytryptamine 2B receptor (5‐HT2BR) in murine models and ex vivo models of scleroderma skin

Arthritis &Rheumatology, EarlyView.
Objective Systemic sclerosis (SSc) is a connective tissue disease with fibrotic remodeling of the skin and various internal organs. SSc is associated with the highest case‐specific mortality of all rheumatic autoimmune diseases with limited antifibrotic treatment options.
Thuong Trinh‐Minh, Cuong Tran‐Manh, Andrea‐Hermina Györfi, Nicholas Dickel, Christoph Liebel, Xiang Zhou, Jiucun Wang, Meik Kunz, Helena Arozenius, Lars Pettersson, Sam Lindgren, Christina Wenglén, Jörg H. W. Distler   +12 more
wiley   +1 more source

Regulation of Chondrocyte Metabolism and Osteoarthritis Development by Sirt5 Through Protein Lysine Malonylation

Arthritis &Rheumatology, EarlyView.
Objective Chondrocytemetabolic dysfunction plays an important role in osteoarthritis (OA) development during aging and obesity. Protein posttranslational modifications (PTMs) have recently emerged as an important regulator of cellular metabolism. We aim to study one type of PTM, lysine malonylation (MaK), and its regulator sirtuin 5 (Sirt5) in OA ...
Huanhuan Liu, Anupama Binoy, Siqi Ren, Thomas C. Martino, Anna E. Miller, Craig R. G. Willis, Shivakumar R. Veerabhadraiah, Joanna Bons, Jacob P. Rose, Birgit Schilling, Michael J. Jurynec, Shouan Zhu   +11 more
wiley   +1 more source

A role for class I PAKs in the regulation of the excitability of the actin cytoskeleton

Tyler JJ, Davidson A, Poxon ME, Martinez ML, Hume P, King JS, Koronakis V.   +6 more
europepmc   +1 more source

The actin cytoskeleton plays multiple roles in structural colour formation in butterfly wing scales. [PDF]

Nat Commun
Lloyd VJ, Burg SL, Harizanova J, Garcia E, Hill O, Enciso-Romero J, Cooper RL, Flenner S, Longo E, Greving I, Nadeau NJ, Parnell AJ.   +11 more
europepmc   +1 more source

Aberrant glycosylation of IgG in children with active lupus nephritis alters podocyte metabolism and causes podocyte injury

Arthritis &Rheumatology, Accepted Article.
Background Podocytes are integral to the maintenance of the glomerular filtration barrier. Their injury results in proteinuria and disease progression in lupus nephritis (LN). Aberrant IgG glycosylation drives podocyte injury in LN and leads to cytoskeletal rearrangement, motility changes and decreased nephrin production.
Rhea Bhargava, Rohit Upadhyay, Cong Zhao, Prasad Katakam, Scott Wenderfer, Jing Chen, Hua He, Richard Cummings, Maria G. Tsokos, George C. Tsokos   +9 more
wiley   +1 more source

Pan-cancer and single-cell analysis of actin cytoskeleton genes related to disulfidptosis. [PDF]

Open Med (Wars)
Shen LP, Jiang HT.
europepmc   +1 more source

m6A‐mRNA Reader YTHDF2 Identified as a Potential Risk Gene in Autism With Disproportionate Megalencephaly

Autism Research, EarlyView.
ABSTRACT Among autistic individuals, a subphenotype of disproportionate megalencephaly (ASD‐DM) seen at three years of age is associated with co‐occurring intellectual disability and poorer prognoses later in life. However, many of the genes contributing to ASD‐DM have yet to be delineated. In this study, we identified additional ASD‐DM candidate genes
Sierra S. Nishizaki, Nicholas K. Haghani, Gabriana N. La, Natasha Ann F. Mariano, José M. Uribe‐Salazar, Gulhan Kaya, Melissa Regester, Derek Sayre Andrews, Christine Wu Nordahl, David G. Amaral, Megan Y. Dennis   +10 more
wiley   +1 more source

Heat Stress Induces Alterations in Gene Expression of Actin Cytoskeleton and Filament of Cellular Components Causing Gut Disruption in Growing-Finishing Pigs. [PDF]

Animals (Basel)
Choi Y, Park H, Kim J, Lee H, Kim M.
europepmc   +1 more source

Dynamic Remodeling of Mechano‐Sensing Complexes in Suspended Fibroblast Cell‐Sheets Under External Mechanical Stimulus

Biotechnology and Bioengineering, EarlyView.
A cell‐sheet prepared from NIH 3T3 cells was sustained by a pair of glass microneedles above a glass‐bottom dish under the spinning disc confocal microscope equipped with a dual‐view system (left). The cell‐sheet was mechanically stretched by moving one of the microneedles away from the other and the locations of proteins related to focal adhesion were
Madoka Suzuki, Keiko Kawauchi, Hiroaki Machiyama, Hiroaki Hirata, Shin'ichi Ishiwata, Hideaki Fujita   +5 more
wiley   +1 more source

Molecular simulation approaches to probing the effects of mechanical forces in the actin cytoskeleton. [PDF]

Cytoskeleton (Hoboken)
Mukadum F, Peña Ccoa WJ, Hocky GM.
europepmc   +1 more source