Results 241 to 250 of about 374,310 (333)

Nicotinamide mononucleotide biosynthesis and the F-actin cytoskeleton regulate spindle assembly and oocyte maturation quality in post-ovulatory aged porcine oocytes. [PDF]

Cell Commun Signal
Park HJ, Yang SG, Shin JH, Yoon SB, Kim JS, Koo DB.   +5 more
europepmc   +1 more source

Role of Tunneling Nanotubes in Arachidonic Acid Transfer and Macrophage Function Reprogramming in Intrahepatic Cholangiocarcinoma

Advanced Science, EarlyView.
Tunneling nanotubes facilitate the transfer of long‐chain fatty acids, primarily arachidonic acid, from tumor cells to macrophages, leading to lipid accumulation and activation of the PI3K‐Akt pathway. This drives a shift from the anti‐tumor CD5L⁺ phenotype to a pro‐tumor TREM2⁺ phenotype.
Meiru Chen, Shangyumeng Zhao, Xiaoli Xie, Jiaqi Wang, Miao Su, Lixian Zhang, Ruolin Cui, Dongqiang Zhao   +7 more
wiley   +1 more source

Calponin 3 Regulates Myoblast Proliferation and Differentiation Through Actin Cytoskeleton Remodeling and YAP1-Mediated Signaling in Myoblasts. [PDF]

Cells
Nguyen MT, Ly QK, Ngo THP, Lee W.
europepmc   +1 more source

Kindlin Regulates Mechanosensitive Activation and Adhesion Assembly of Integrin beta6

Advanced Science, EarlyView.
Extracellular matrix compliance plays a critical role in the regulation of integrin‐mediated adhesion and cell motility. Here, it is reported that strengthening the kindlin2‐integrin β6 interaction overcomes the dependence on extracellular substrate stiffness and promotes integrin β6‐mediated cell migration.
Wan Ning Lee, Jiamin Li, Nan‐Peng Chen, Cheng‐han Yu   +3 more
wiley   +1 more source

Piezo1 Activation Improves NSCLC Liver Metastasis Immunotherapy by Overriding Matrix Stiffness‐Mediated Bimodal PD‐L1/CXCL10 Regulation

Advanced Science, EarlyView.
This study demonstrates that Piezo1 activation enhances FAK‐YAP‐mediated upregulation of PD‐L1 and CXCL10, thereby promoting an immunotherapy‐responsive tumor microenvironment in NSCLC. Cyclic stretch modulates the PD‐L1/CXCL10 response to ECM stiffness, reshaping their expression dynamics.
Tian Zhang, Yuan Li, Bo Cheng, Zhao Xu, Mengjie Liu, Jinteng Feng, Yixue Bai, Yang Yu, Panpan Jiang, Luying Geng, Feng Xu, Hui Guo   +11 more
wiley   +1 more source

The influences of ApoE isoforms on endothelial adherens junctions and actin cytoskeleton responding to mCRP. [PDF]

Angiogenesis
Zhang Z, Lin W, Gan Q, Lei M, Gong B, Zhang C, Henrique JS, Han J, Tian H, Tao Q, Potempa LA, Stein TD, Emili A, Qiu WQ.   +13 more
europepmc   +1 more source

LIM proteins in actin cytoskeleton mechanoresponse.

Trends in Cell Biology, 2014
Mark A. Smith, Mark A. Smith, Laura M. Hoffman, Laura M. Hoffman, M. Beckerle, M. Beckerle   +5 more
semanticscholar   +1 more source

RPL6 Interacts with HMGCS1 to Stabilize HIF‐1α by Promoting Cholesterol Production in Hepatocellular Carcinoma

Advanced Science, EarlyView.
The study found that RPL6 is frequently upregulated in HCC tissues with extrahepatic metastasis. Elevated RPL6 bound to and increased the stability of HMGCS1 mRNA, thereby enhancing intracellular cholesterol levels. Subsequently, increased cholesterol promotes cancer metastasis in HCC by stabilizing HIF‐1α protein.
Minli Yang, Shengtao Cheng, Huiying Gu, Shan Zhong, Dapeng Zhang, Xin He, Weixian Chen, Haijun Deng, Jihua Ren, Peng Chen, Ming Tan, Hui Zhang, Fan Li, Zhenzhen Zhang, Yuan Hu, Juan Chen   +15 more
wiley   +1 more source

The Ca²⁺-actin-cytoskeleton axis in podocytes is an important, non-immunologic target of immunosuppressive therapy in proteinuric kidney diseases. [PDF]

Pediatr Nephrol
Hackl A, Weber LT.
europepmc   +1 more source

The polycystic kidney disease protein PKD2 interacts with Hax-1, a protein associated with the actin cytoskeleton

, 2000
Anna‐Rachel Gallagher, Anna Cedzich, Norbert Gretz, Stefan Somlo, Ralph Witzgall   +4 more
openalex   +1 more source