Results 251 to 260 of about 287,702 (305)

Establishing a 3D Vascularized Tri‐Culture Model of the Human Airways via a Digital Light Processing Bioprinter

Biotechnology and Bioengineering, EarlyView.
ABSTRACT The rise in chronic lung diseases globally and the corresponding lag in drug discovery in this field highlights the need for In Vitro models closely mimicking In Vivo lung tissue. Efforts to date have largely focused on In Vitro coculture models, often neglecting the pulmonary vasculature's role in lung physiology and lacking perfusability. To
Sakshi Phogat, Tony Ju Feng Guo, Fama Thiam, Emmanuel Twumasi Osei   +3 more
wiley   +1 more source

3D‐cultured BMSC exosomes improve cerebral ischemia/reperfusion injury‐induced neuronal apoptosis by regulating the microglia polarization

BMEMat, EarlyView.
The study reveals that microglial activation significantly contributes to neuroinflammation following cerebral ischemia‐reperfusion injury. It demonstrates that utilizing GelMA hydrogel for three‐dimensional culture of bone marrow‐derived mesenchymal stem cells (BMSCs) enhances the efficacy of BMSC‐derived exosomes in regulating microglial polarization
Yuming Li, Hao Shang, Qiong Zhang, Xianyong Yin, Zihao Liu, Yuqing Fang, Kyubae Lee, Huayang Zhao, Zhihai Wang, Hongbo Zhao, Xiaofeng Wang, Shengjie Li, Shan Wang, Tao Xin   +13 more
wiley   +1 more source

CHRFAM7A diversifies human immune adaption through Ca²⁺ signalling and actin cytoskeleton reorganization. [PDF]

EBioMedicine
Szigeti K, Ihnatovych I, Notari E, Dorn RP, Maly I, He M, Birkaya B, Prasad S, Byrne RS, Indurthi DC, Nimmer E, Heo Y, Retfalvi K, Chaves L, Sule N, Hofmann WA, Auerbach A, Wilding G, Bae Y, Reynolds J.   +19 more
europepmc   +1 more source

Bioorthogonal Postlabeling Reveals Nuclear Localization of a Highly Cytotoxic Half‐Sandwich Ir(III) Tetrazine Complex in Live Cells

ChemBioChem, EarlyView.
This study reports the synthesis of five tetrazine‐coordinated, half‐sandwich iridium complexes and extensively describe their reactivity. Live cell fluorescent bioorthogonal labeling reveals the nuclear tropism of the most cytotoxic complex. Intracellular imaging of anticancer metallodrugs often relies on prelabeling with organic fluorophores, which ...
Alfonso Annunziata, Sadek Amhaz, Jérémy Forté, Geoffrey Gontard, Romain Morichon, Joëlle Sobczak‐Thépot, Michèle Salmain   +6 more
wiley   +1 more source

Pleiotropic regulatory locus 1 maintains actin cytoskeleton integrity and cellular homeostasis to enable Arabidopsis root growth. [PDF]

iScience
Wang C, Wang X, Yang Z, Gao X.
europepmc   +1 more source

Methods for Controlling Small GTPase Activity

ChemBioChem, Accepted Article.
Small GTPases comprise a diverse class of signaling proteins in mammalian cells and regulate a variety of cellular processes such as cell growth, cell movement, vesicle formation, and nuclear transport. Due to their involvement in critical cellular pathways, changes in the activation state of small GTPases due to genetic mutations or alterations in ...
Benjamin Faulkner, Yuchen He, Daniel Sitrin, Cliff Stains   +3 more
wiley   +1 more source

Covalent Peptide‐Graphene Conjugates for Enhanced Cell Spreading, Osteogenic Differentiation, and Angiogenesis in Bone Defects

ChemBioChem, EarlyView.
The three peptides RGD, DGEA, and KKGHK are covalently attached to the 2D nanomaterial graphene oxide (GO) to create new biomaterials for the treatment of severe bone injuries. These GO modifications improve cell spreading, stem cell differentiation into bone cell types, and formation of blood vessel‐like structures.
Michelle E. Wolf, Yaxuan Liu, Jason D. Orlando, Jingzhi Zhou, Stefanie A. Sydlik   +4 more
wiley   +1 more source

Scinderin promotes glioma cell migration and invasion via remodeling actin cytoskeleton. [PDF]

World J Clin Oncol
Lin X, Zhao Z, Sun SP, Liu W.
europepmc   +1 more source

Distribution of Troy (Tnfrsf19) in the Gastric Gland During Postnatal Development: Effects of Early Weaning

Cell Biology International, EarlyView.
ABSTRACT This study investigates the distribution and role of the stem cell marker Troy (Tnfrsf19) in the gastric mucosa of rats during postnatal development and the effects of early weaning. Troy, previously identified as a reserve stem cell marker in adult gastric tissues, is examined across various developmental stages from birth to adulthood.
Isadora Campos Rattes, Kethleen Mesquita da Silva, Patrícia Gama   +2 more
wiley   +1 more source