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Actin depolymerizing factors cofilin1 and destrin are required for ureteric bud branching morphogenesis. [PDF]

open access: yesPLoS Genetics, 2010
The actin depolymerizing factors (ADFs) play important roles in several cellular processes that require cytoskeletal rearrangements, such as cell migration, but little is known about the in vivo functions of ADFs in developmental events like branching ...
Satu Kuure   +9 more
doaj   +2 more sources

Research progress on the roles of actin-depolymerizing factor in plant stress responses

open access: yesFrontiers in Plant Science, 2023
Actin-depolymerizing factors (ADFs) are highly conserved small-molecule actin-binding proteins found throughout eukaryotic cells. In land plants, ADFs form a small gene family that displays functional redundancy despite variations among its individual ...
Gong Yujie, Sun Yongwang, Wang Deying
exaly   +3 more sources

Genome-wide identification of the ADF gene family and expression analysis of responses to cold stress in bitter gourd [PDF]

open access: yesBMC Plant Biology
Background Actin-depolymerizing factors (ADFs) maintain actin dynamics depending on the local concentration in cells, regulating the severing and disassembly of actin filaments at low concentrations, whereas they contribute to actin nucleation and Pi ...
Xuetong Yang   +5 more
doaj   +2 more sources

TaADF3, an Actin-Depolymerizing Factor, Negatively Modulates Wheat Resistance Against Puccinia striiformis

open access: yesFrontiers in Plant Science, 2016
The actin cytoskeleton has been implicated in plant defense against pathogenic fungi, oomycetes and bacteria. Actin depolymerizing factors (ADF) are stimulus responsive actin cytoskeleton modulators.
Zhensheng Kang   +2 more
exaly   +3 more sources

Genome-wide characterization and expression analysis of the ADF gene family in response to salt and drought stress in alfalfa (Medicago sativa) [PDF]

open access: yesFrontiers in Plant Science
The microfilament cytoskeleton, formed by the process of actin polymerization, serves not only to support the morphology of the cell, but also to regulate a number of cellular activities.
Mengmeng Shi   +12 more
doaj   +2 more sources

ADF and cofilin-1 collaborate to promote cortical actin flow and the leader bleb-based migration of confined cells

open access: yeseLife, 2021
Melanoma cells have been shown to undergo fast amoeboid (leader bleb-based) migration, requiring a single large bleb for migration. In leader blebs, is a rapid flow of cortical actin that drives the cell forward.
Maria F Ullo, Jeremy S Logue
doaj   +1 more source

Induction of miR-665-3p Impairs the Differentiation of Myogenic Progenitor Cells by Regulating the TWF1-YAP1 Axis

open access: yesCells, 2023
Actin dynamics are known to orchestrate various myogenic processes in progenitor cells. Twinfilin-1 (TWF1) is an actin-depolymerizing factor that plays a crucial role in the differentiation of myogenic progenitor cells. However, little is known about the
Mai Thi Nguyen, Wan Lee
doaj   +1 more source

Immunological responses and actin dynamics in macrophages are controlled by N-cofilin but are independent from ADF. [PDF]

open access: yesPLoS ONE, 2012
Dynamic changes in the actin cytoskeleton are essential for immune cell function and a number of immune deficiencies have been linked to mutations, which disturb the actin cytoskeleton.
Friederike Jönsson   +4 more
doaj   +1 more source

Arabidopsis ADF5 Acts as a Downstream Target Gene of CBFs in Response to Low-Temperature Stress

open access: yesFrontiers in Cell and Developmental Biology, 2021
Low temperature is a major adverse environment that affects normal plant growth. Previous reports showed that the actin cytoskeleton plays an important role in the plant response to low-temperature stress, but the regulatory mechanism of the actin ...
Pan Zhang   +8 more
doaj   +1 more source

Cofilin and Actin Dynamics: Multiple Modes of Regulation and Their Impacts in Neuronal Development and Degeneration

open access: yesCells, 2021
Proteins of the actin depolymerizing factor (ADF)/cofilin family are ubiquitous among eukaryotes and are essential regulators of actin dynamics and function.
James R. Bamburg   +4 more
doaj   +1 more source

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