Results 31 to 40 of about 6,799 (175)

Regulators of Actin Dynamics in Gastrointestinal Tract Tumors

Gastroenterology Research and Practice, 2015
Reorganization of the actin cytoskeleton underlies cell migration in a wide variety of physiological and pathological processes, such as embryonic development, wound healing, and tumor cell invasion.
Konrad Steinestel, Eva Wardelmann, Wolfgang Hartmann, Inga Grünewald   +3 more
doaj   +1 more source

Arabidopsis Actin-Depolymerizing Factor-4 links pathogen perception, defense activation and transcription to cytoskeletal dynamics.

PLoS Pathogens, 2012
The primary role of Actin-Depolymerizing Factors (ADFs) is to sever filamentous actin, generating pointed ends, which in turn are incorporated into newly formed filaments, thus supporting stochastic actin dynamics.
Katie Porter, Masaki Shimono, Miaoying Tian, Brad Day   +3 more
doaj   +1 more source

Linkage mapping and genome-wide association study reveals conservative QTL and candidate genes for Fusarium rot resistance in maize

BMC Genomics, 2020
Background Fusarium ear rot (FER) caused by Fusarium verticillioides is a major disease of maize that reduces grain yield and quality globally. However, there have been few reports of major loci for FER were verified and cloned.
Yabin Wu, Zijian Zhou, Chaopei Dong, Jiafa Chen, Junqiang Ding, Xuecai Zhang, Cong Mu, Yuna Chen, Xiaopeng Li, Huimin Li, Yanan Han, Ruixia Wang, Xiaodong Sun, Jingjing Li, Xiaodong Dai, Weibin Song, Wei Chen, Jianyu Wu   +17 more
doaj   +1 more source

Reactivation of Phosphorylated Actin Depolymerizing Factor and Identification of the Regulatory Site [PDF]

Journal of Biological Chemistry, 1995
Actin depolymerizing factor (ADF) occurs naturally in two forms, one of which contains a phosphorylated Ser and does not bind G-actin or depolymerize F-actin. Removal of this phosphate in vitro by alkaline phosphatase restores full F-actin depolymerizing activity.
B J, Agnew, L S, Minamide, J R, Bamburg
openaire   +2 more sources

Cofilin-1: a modulator of anxiety in mice.

PLoS Genetics, 2012
The genes involved in conferring susceptibility to anxiety remain obscure. We developed a new method to identify genes at quantitative trait loci (QTLs) in a population of heterogeneous stock mice descended from known progenitor strains.
Martin Goodson, Marco B Rust, Walter Witke, David Bannerman, Richard Mott, Chris P Ponting, Jonathan Flint   +6 more
doaj   +1 more source

Effect of terahertz irradiation on DNA damage repair in living cells

FEBS Open Bio, EarlyView.
We investigated the effect of terahertz (THz) wave irradiation on DNA double‐strand break (DSB) repair in living cells. We found that THz irradiation enhanced DSB repair at specific frequencies, whereas heat treatment inhibited it, indicating that this effect is nonthermal and frequency‐specific.
Yuya Ueno, Shota Yamazaki, Hiromichi Hoshina, Masahiko Harata   +3 more
wiley   +1 more source

Malformin A1–mediated cytotoxicity in ovarian cancer cells occurs through pyroptosis and autophagy

FEBS Open Bio, EarlyView.
This study investigated the effects of the natural compound Malformin A1 (MA1) on the cytoskeleton that regulates cell proliferation and migration. Disruption of the cytoskeleton can impair these processes and promote cancer cell death. MA1 disrupted cytoskeletal organization, induced DNA damage, inflammation, activated autophagy, and pyroptosis ...
Nada Abdullah Hassan, Ikram A. Burney, Shika Hanif Malgundkar, Siva Ramamoorthy, Ressin Varghese, Mohamed A. Al‐Kindi, Hamad Al Riyami, Shadia Al Bahlani, Sergey Dobretsov, Syed Imran Hassan, Benjamin K. Tsang, Yahya Tamimi   +11 more
wiley   +1 more source

Regulation of a Wheat Actin-Depolymerizing Factor during Cold Acclimation [PDF]

Plant Physiology, 2001
Abstract We have previously shown that the wheat (Triticum aestivum) TaADF gene expression level is correlated with the plants capacity to tolerate freezing. Sequence analysis revealed that this gene encodes a protein homologous to members of the actin-depolymerizing factor (ADF)/cofilin family.
F, Ouellet, E, Carpentier, M J, Cope, A F, Monroy, F, Sarhan   +4 more
openaire   +2 more sources

Genome-wide identification of actin-depolymerizing factor family genes in melon (Cucumis melo L.) and CmADF1 plays an important role in low temperature tolerance

Frontiers in Plant Science
Actin depolymerizing factors (ADFs), as the important actin-binding proteins (ABPs) with depolymerizing/severing actin filaments, play a critical role in plant growth and development, and in response to biotic and abiotic stresses.
Yanling Lv, Yanling Lv, Yanling Lv, Shihang Liu, Jiawang Zhang, Jianing Cheng, Jinshu Wang, Lina Wang, Mingyang Li, Lu Wang, Shuangtian Bi, Wei Liu, Lili Zhang, Shilei Liu, Dabo Yan, Chengxuan Diao, Shaobin Zhang, Ming He, Yue Gao, Che Wang   +19 more
doaj   +1 more source

Chemically Fueled Systems Chemistry Across Length Scales

Advanced Functional Materials, EarlyView.
Chemically fueled reaction cycles regulate processes through single and multiple catalytic sites on the molecular and assembly scale. This gives rise to unique kinetically controlled properties/functions like spatio‐temporal catalysis, oscillations, optical properties, and perform work.
Brigitte A. K. Kriebisch, Job Boekhoven
wiley   +1 more source