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Applied Radiation and Isotopes, 2022
Although alpha-emitting radioisotopes have favorable characteristics for limiting external exposure to radiation workers, there are significant dose consequences associated with accidental internal uptake. Consequently, regulatory requirements and license restrictions are designed to limit such risks to users.
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Although alpha-emitting radioisotopes have favorable characteristics for limiting external exposure to radiation workers, there are significant dose consequences associated with accidental internal uptake. Consequently, regulatory requirements and license restrictions are designed to limit such risks to users.
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LaPO4 Nanoparticles Doped with Actinium-225 that Partially Sequester Daughter Radionuclides
Bioconjugate Chemistry, 2011Nanoscale materials have been envisioned as carriers for various therapeutic drugs, including radioisotopes. Inorganic nanoparticles (NPs) are particularly appealing vehicles for targeted radiotherapy because they can package several radioactive atoms into a single carrier and can potentially retain daughter radioisotopes produced by in vivo generators
Jonathan, Woodward +7 more
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Clinical Studies with Bismuth-213 and Actinium-225 for Hematologic Malignancies
Current Radiopharmaceuticals, 2018Due to the shorter range and higher linear energy transfer of α-particles compared to β-particles, targeted α-particle therapy may produce more efficient tumor killing while sparing neighboring healthy cells. We will review the clinical studies using α-particle therapy for Acute Myeloid Leukemia (AML).A series of clinical trials were conducted to ...
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Liposomal Actinium-225 as a potential cancer therapeutic
2017Alpha-particle emitting radionuclides are a promising class of emitters for the treatment of cancer. Emitted alpha-particles deposit considerable energy along a short-ranged trajectory (<100 µm), allowing the potential for highly localized and cytotoxic irradiation of cancer while sparing the surrounding healthy tissues from off-target effects. The
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Production and Quality Control of Actinium-225 Radiopharmaceuticals
This publication includes existing experiences, lessons learned, challenges and future developments in the production of Ac-225 radiopharmaceuticals for Targeted Alpha Therapy (TAT). This publication will be utilized by all involved professionals in the Targeted Alpha Therapy field, specifying ideal production, formulation, quality control and ...openaire +1 more source