Development of highly efficient and specific base editors in Actinobacillus succinogenes for enhancing succinic acid production [PDF]
Biotechnology for Biofuels and Bioproducts, 2023 The production of bio-succinic acid (SA) from renewable feedstocks is a promising and sustainable approach to mitigating the high carbon emissions associated with the current energy crisis.
Chunmei Chen +3 more
doaj +2 more sources
Comparative Transcriptome Analysis Reveals the Molecular Mechanisms of Acetic Acid Reduction by Adding NaHSO3 in Actinobacillus succinogenes GXAS137 [PDF]
Polish Journal of Microbiology, 2023 Acetic acid (AC) is a major by-product from fermentation processes for producing succinic acid (SA) using Actinobacillus succinogenes. Previous experiments have demonstrated that sodium bisulfate (NaHSO3) can significantly decrease AC production by A ...
Li Shiyong +5 more
doaj +2 more sources
Biotechnological enhancement of lactic acid conversion from pretreated palm kernel cake hydrolysate by Actinobacillus succinogenes 130Z [PDF]
Scientific Reports, 2023 The aim of this study was to establish an improved pretreatment and fermentation method i.e. immobilized cells for high recovery of fermentable sugars from palm kernel cake (PKC) and its effects on fermentability performance by Actinobacillus ...
Nuraishah Abd Rahim +5 more
doaj +2 more sources
Progress of fermentation methods for bio-succinic acid production using agro-industrial waste by Actinobacillus succinogenes [PDF]
Energy Reports, 2020 Production of bio-succinic acid through microbial fermentation using agro-industrial waste has been observed extensively. Large scale production is now being considered since bio-succinic acid has broad range application in several industries including ...
Dwini Normayulisa Putri +5 more
doaj +4 more sources
Effects of down-regulation of ackA expression by CRISPR-dCpf1 on succinic acid production in Actinobacillus succinogenes [PDF]
AMB Express, 2023 Keypoints CRISPRi based on FnCpf1 and SpCas9opt was established in A. succinogenes. The target gene, ackA was repressed ~ eightfold by CRISPR-dCpf1. Repression of ackA increased succinate yield compared with ackA deletion.
Chunmei Chen, Pu Zheng
doaj +2 more sources
One step forward, two steps back: Transcriptional advancements and fermentation phenomena in Actinobacillus succinogenes 130Z. [PDF]
PLoS ONE, 2021 Within the field of bioproduction, non-model organisms offer promise as bio-platform candidates. Non-model organisms can possess natural abilities to consume complex feedstocks, produce industrially useful chemicals, and withstand extreme environments ...
Dianna S Long +4 more
doaj +2 more sources
Metabolic Regulation of Organic Acid Biosynthesis in Actinobacillus succinogenes [PDF]
Frontiers in Bioengineering and Biotechnology, 2019 Actinobacillus succinogenes is one of the most promising strains for succinic acid production; however, the lack of efficient genetic tools for strain modification development hinders its further application.
Wenming Zhang +13 more
doaj +2 more sources
Prediction of reaction knockouts to maximize succinate production by Actinobacillus succinogenes. [PDF]
PLoS ONE, 2018 Succinate is a precursor of multiple commodity chemicals and bio-based succinate production is an active area of industrial bioengineering research. One of the most important microbial strains for bio-based production of succinate is the capnophilic gram-
Ambarish Nag +3 more
doaj +2 more sources
Biotechnological Synthesis of Succinic Acid By Actinobacillus succinogenes by Exploitation of Lignocellulosic Biomass [PDF]
Chemical Engineering Transactions, 2017 Succinic acid is increasingly used in pharmaceutical industries, for the production of additives in food industries, in agriculture and in refinery processes as a precursor of many chemical compounds among which the most important is the succinate salt ...
D. Pirozzi +7 more
doaj +2 more sources
Reconstruction of a genome-scale metabolic model for Actinobacillus succinogenes 130Z [PDF]
BMC Syst Biol, 2018 Background Actinobacillus succinogenes is a promising bacterial catalyst for the bioproduction of succinic acid from low-cost raw materials. In this work, a genome-scale metabolic model was reconstructed and used to assess the metabolic capabilities of ...
Carneiro, Sónia +5 more
core +3 more sources