Results 181 to 190 of about 1,854,011 (302)

Axon collateralization and focal myelin dystrophy alter action potential propagation in multicompartment pyramidal neuron models. [PDF]

PLoS Comput Biol
Sengupta N, Luebke JI, Weaver CM.
europepmc   +1 more source

174 FUNCTIONAL CORE MODULATION FOLLOWING TREATMENT OF MINIMAL HEPATIC ENCEPHALOPATHY WITH L-ORNITHINE L-ASPARTATE: A POTENTIAL NOVEL MECHANISM OF ACTION

, 2011
M Mcphail, Robert Leech, Vijay P.B. Grover, Julie Fitzpatrick, Novraj S. Dhanjal, Brian K. Saxby, Keith Wesnes, H.C. Thomas, RM Wise, Simon D. Taylor‐Robinson   +9 more
openalex   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Spatial characterization of backpropagating action potential-evoked Ca²⁺ signals in human cortical layer 2/3 pyramidal neurons. [PDF]

Front Synaptic Neurosci
Szöts I, Tóth M, Ludányi C, Barzó P, Csajbók ÉA, Tamás G, Molnár G.   +6 more
europepmc   +1 more source

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

Molecular Oncology, EarlyView.
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann, Eduardo García‐Galea, Alice O'Farrell, Zak Kinsella, Maxime Meylan, Florent Petitprez, Ingrid Arijs, Tom Venken, Hari Ps, Adrian Lärkeryd, Ian Miller, Janick Selves, Nadja Meindl‐Beinker, Fiorella Ruiz‐Pace, Elena Élez, Raquel Comas‐Navarro, Frank Lincoln, Dirk Fey, Gift Nyamundanda, Aoife Nolan, Joern Lewin, Raquel Perez‐Lopez, Jonathan Briody, Kathleen Bennett, Walter Kolch, David Matallanas, Alexander Kel, Enrique Arenas, Joaquín Arribas, Bart Ghesquière, Josep Tabernero, Julie Meilleroux, Deborah McNamara, Ray McDermott, Marvin Lim, Mary O'Reilly, Brian Bird, Lisa Stack, Lucia Moloney, Patrick Morris, Keith Egan, Maciej Milewski, Lars Scheuer, Joachim Behringer, Georg Bolz, Ramon Salazar, Cristina Santos, Andrea Ruiz, Orla Casey, Verena Murphy, Matthias Ebert, Livio Trusolino, Diether Lambrechts, Anguraj Sadanandam, Catherine Sautès‐Fridman, Jochen Prehn, Paolo Nuciforo, Jacques Fieschi, Florence Monville, Darran O'Connor, Wolf Fridman, Annette Byrne   +61 more
wiley   +1 more source

Biomimetic action-potential transmission via mechano-gated potassium channels assembled by quadruple hydrogen-bonded crown ethers. [PDF]

Sci Adv
Li C, Chen C, Shi J, Han W, Fu Q, Yang L.   +5 more
europepmc   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Subarachnoid hemorrhage mediates human neocortical network, membrane potential, and action potential bursting via glutamate receptors. [PDF]

Commun Biol
Huang DF, Chou MY, Lee YH, Chen YT, Sun CK, Wang KC, Huang HS.   +6 more
europepmc   +1 more source

The effects of action potential propagation delay times and an absolute refractory period upon the synchronization index in the integrate and fire neuron model and a comparison with neurons in the auditory pathway

, 2000
Levin Kuhlmann, A. N. Burkitt, Graeme M. Clark   +2 more
openalex   +1 more source

Black-faced, red faces: the potentials of humour for anti-racist action

, 2015
Scott Sharpe, Maria Hynes
openalex   +2 more sources