Results 21 to 30 of about 40,111 (286)

Adeno‐associated virus serotype 2 capsid variants for improved liver‐directed gene therapy

Hepatology, EarlyView., 2022
Abstract Background and Aims Current liver‐directed gene therapies look for adeno‐associated virus (AAV) vectors with improved efficacy. With this background, capsid engineering is explored. Whereas shuffled capsid library screenings have resulted in potent liver targeting variants with one first vector in human clinical trials, modifying natural ...
Nadja Meumann, Marti Cabanes‐Creus, Moritz Ertelt, Renina Gale Navarro, Julie Lucifora, Qinggong Yuan, Karin Nien‐Huber, Ahmed Abdelrahman, Xuan‐Khang Vu, Liang Zhang, Ann‐Christin Franke, Christian Schmithals, Albrecht Piiper, Annabelle Vogt, Maria Gonzalez‐Carmona, Jochen T. Frueh, Evelyn Ullrich, Philip Meuleman, Steven R. Talbot, Margarete Odenthal, Michael Ott, Erhard Seifried, Clara T. Schoeder, Joachim Schwäble, Leszek Lisowski, Hildegard Büning   +25 more
wiley   +1 more source

Biological evaluation of the effect of sugammadex on hemostasis and bleeding [PDF]

Korean Journal of Anesthesiology, 2015
BackgroundNotification of sugammadex has been supplemented with a section on hemostasis, including a longer clotting time in the first minutes following injection, without any documented clinical consequences.
Julien Raft, Philippe Guerci, Valentin Harter, Thomas Fuchs-Buder, Claude Meistelman   +4 more
doaj   +1 more source

Performance Evaluation of Four Activated Partial Thromboplastin Time Reagents

Pharmacology and Clinical Pharmacy Research, 2018
Activated Partial Thromboplastin Time (APTT) is a hematological examination to identify hemostatic abnormalities. This study aimed to compare the performance evaluation of four APTT reagents, i.e., CK Prest, Pathromtin SL, Actin SL, and Cephascreen.
Peppi Z. Yuzaqi, Eli Halimah, Tatat Noviani   +2 more
doaj   +1 more source

Effect on haemostasis of different replacement fluids during therapeutic plasma exchange—A comparative multicentre observational study

Journal of Clinical Apheresis, Volume 37, Issue 6, Page 534-543, December 2022., 2022
Abstract Introduction Therapeutic plasma exchange (TPE) is used for several chronic conditions with little evidence on the efficacy and safety of different choice of replacement fluid. Measurement of haemostasis, particularly in vitro thrombin generation, could play a role in determining the immediate efficacy of different fluid replacement.
Ruchika Kohli, Elisa Allen, Sean Platton, James Griffin, Lynn Manson, Peter MacCallum, Laura Green   +6 more
wiley   +1 more source

The role of hemostatic changes in the pathogenesis of diabetic retinopathy

Journal of Education, Health and Sport, 2022
Introduction: The paper presents the results of the hemostasis system of rats with experimental diabetic retinopathy. Material and methods: Experimental studies were performed on white Wistar rats, which were divided into 2 groups: 1st group – intact
Nataliya Preys, Ivan Savytskyi
doaj   +1 more source

Risk for excessive anticoagulation during hemodialysis is associated with type of vascular access and bedside coagulation testing: Results of a cross-sectional study

Frontiers in Medicine, 2022
BackgroundRecommendations and practice patterns for heparin dosing during hemodialysis show substantial heterogeneity and are scantly supported by evidence.
Marijke De Troyer, Karl Martin Wissing, Dieter De Clerck, Marie-Laure Cambier, Tom Robberechts, Annelies Tonnelier, Karlien François   +6 more
doaj   +1 more source

Aromatic Amines Exert Contrasting Effects on the Anticoagulant Effect of Acetaldehyde upon APTT

Advances in Hematology, 2014
The pharmacological effects of amphetamine, procaine, procainamide, DOPA, isoproterenol, and atenolol upon activated partial thromboplastin time in the absence and presence of acetaldehyde have been investigated.
La'Teese Hall, Sarah J. Murrey, Arthur S. Brecher   +2 more
doaj   +1 more source

Prothrombine and activated partial thromboplastin time are prolonged in hepatic cirrhosis

Universa Medicina, 2016
Background Chronic hepatitis and hepatic cirrhosis are chronic liver diseases that cause disorders of liver function, such as the formation of platelets and coagulation factors (prothrombin time/PT and activated partial thromboplastin time/APTT ...
Edward Kurnia Setiawan Limijadi, Lisyani Budi Suromo, Imam Budiwiyono   +2 more
doaj   +1 more source

Successful conservative management of pathological mandibular fracture resulting from chronic osteomyelitis in a 90‐year‐old woman

Oral Science International, Volume 20, Issue 1, Page 42-47, January 2023., 2023
Abstract Background We report the successful conservative management of a pathological mandibular fracture resulting from chronic osteomyelitis in a super‐elderly patient. Case Presentation A 90‐year‐old woman was admitted because of an external dental fistula with purulent drainage. Radiographs showed extensive bone destruction in the mandible.
Ryutaro Ono, Takeshi Amemiya, Toshiro Yamamoto, Narisato Kanamura   +3 more
wiley   +1 more source

Use of the Activated Partial Thromboplastin Time for Heparin Monitoring [PDF]

American Journal of Clinical Pathology, 2001
The objectives of the present study were to evaluate the relationship between heparin concentration and activated partial thromboplastin time (aPTT) results, define a heparin concentration-derived therapeutic range for each aPTT instrument, compare aPTT- and heparin concentration-guided dosage adjustment decisions, and compare laboratory- and bedside ...
Maureen A. Smythe, Mamtha Balasubramaniam, Sandra N. Nowak, John M. Koerber, John M. Koerber, Robert L Begle, Susan J. Westley, Joan C. Mattson   +7 more
openaire   +3 more sources