Results 41 to 50 of about 693,055 (312)

Reprogramming of lysosomal gene expression by interleukin-4 and Stat6. [PDF]

, 2013
BACKGROUND: Lysosomes play important roles in multiple aspects of physiology, but the problem of how the transcription of lysosomal genes is coordinated remains incompletely understood.
Bartlett, NW, Brignull, LM, Czimmerer, Z, Daniel, B, Johnston, SL, Meira, LB, Nagy, L, Nohturfft, A, Saidi, H, Villela, I   +9 more
core   +2 more sources

STAT6 and PARP Family Members in the Development of T Cell-dependent Allergic Inflammation [PDF]

, 2016
Allergic inflammation requires the orchestration of altered gene expression in the target tissue and in the infiltrating immune cells. The transcription factor STAT6 is critical in activating cytokine gene expression and cytokine signaling both in the ...
Kaplan, Mark H., Krishnamurthy, Purna
core   +1 more source

DNA binding and transcription activation specificity of hepatocyte nuclear factor 4 [PDF]

Nucleic Acids Research, 1998
Hepatocyte nuclear factor 4 (HNF-4) is an orphan intracellular receptor that appears to be a key factor in the regulation of energy metabolism. In order to gain greater understanding of the binding and activation requirements of HNF-4, we performed genetic analysis of the apoCIII promoter, a promoter that has previously been shown to be highly ...
J D, Fraser, V, Martinez, R, Straney, M R, Briggs   +3 more
openaire   +2 more sources

ATF4 selectively regulates heat nociception and contributes to kinesin-mediated TRPM3 trafficking

Nature Communications, 2021
The molecular mechanisms mediating nociception are unclear. Here, the authors show that the Activating Transcription Factor 4 (ATF4) is important for the response to heat nociception in mice and ATF4 role in mediating protein trafficking in dorsal root ...
Man-Xiu Xie, Xian-Ying Cao, Wei-An Zeng, Ren-Chun Lai, Lan Guo, Jun-Chao Wang, Yi-Bin Xiao, Xi Zhang, Di Chen, Xian-Guo Liu, Xiao-Long Zhang   +10 more
doaj   +1 more source

OPA1 deletion in brown adipose tissue improves thermoregulation and systemic metabolism via FGF21

eLife, 2021
Adrenergic stimulation of brown adipocytes alters mitochondrial dynamics, including the mitochondrial fusion protein optic atrophy 1 (OPA1). However, direct mechanisms linking OPA1 to brown adipose tissue (BAT) physiology are incompletely understood.
Renata O Pereira, Alex Marti, Angela Crystal Olvera, Satya Murthy Tadinada, Sarah Hartwick Bjorkman, Eric Thomas Weatherford, Donald A Morgan, Michael Westphal, Pooja H Patel, Ana Karina Kirby, Rana Hewezi, William Bùi Trân, Luis Miguel García-Peña, Rhonda A Souvenir, Monika Mittal, Christopher M Adams, Kamal Rahmouni, Matthew J Potthoff, E Dale Abel   +18 more
doaj   +1 more source

The Effect of Resistance Training and Berberine Chloride on the Apoptosis-related Unfolded Protein Response Signaling Pathway in the Hippocampus of Diazinon-poisoned Rats

Basic and Clinical Neuroscience, 2021
Introduction: Diazinon is one of the most widely-used organophosphate pesticides in the world. This toxin enters the body in various ways and induces oxidative stress in various tissues.
Ali Esfandiarifar, Mohammad Ali Azarbayjani, Maghsood Peeri, Seyed Behnamedin Jameie   +3 more
doaj  

General Transcription Factor IIA-γ Increases Osteoblast-specific Osteocalcin Gene Expression via Activating Transcription Factor 4 and Runt-related Transcription Factor 2 [PDF]

Journal of Biological Chemistry, 2008
ATF4 (activating transcription factor 4) is an osteoblast-enriched transcription factor that regulates terminal osteoblast differentiation and bone formation. ATF4 knock-out mice have reduced bone mass (severe osteoporosis) throughout life. Runx2 (runt-related transcription factor 2) is a runt domain-containing transcription factor that is essential ...
Shibing, Yu, Yu, Jiang, Deborah L, Galson, Min, Luo, Yumei, Lai, Yi, Lu, Hong-Jiao, Ouyang, Jian, Zhang, Guozhi, Xiao   +8 more
openaire   +2 more sources

Activating transcription factor 4 confers a multidrug resistance phenotype to gastric cancer cells through transactivation of SIRT1 expression. [PDF]

PLoS ONE, 2012
BACKGROUND: Multidrug resistance (MDR) in gastric cancer remains a major challenge to clinical treatment. Activating transcription factor 4 (ATF4) is a stress response gene involved in homeostasis and cellular protection.
Hongwu Zhu, Limin Xia, Yongguo Zhang, Honghong Wang, Wenjing Xu, Hao Hu, Jing Wang, Jing Xin, Yi Gang, Sumei Sha, Bin Xu, Daiming Fan, Yongzhan Nie, Kaichun Wu   +13 more
doaj   +1 more source

The transcription factor ATF5: role in cellular differentiation, stress responses, and cancer. [PDF]

, 2017
Activating transcription factor 5 (ATF5) is a cellular prosurvival transcription factor within the basic leucine zipper (bZip) family that is involved in cellular differentiation and promotes cellular adaptation to stress.
Angelastro, James M, Sears, Thomas K
core   +2 more sources

Krüppel-like factor 4, a novel transcription factor regulates microglial activation and subsequent neuroinflammation [PDF]

Journal of Neuroinflammation, 2010
Abstract Background Activation of microglia, the resident macrophages of the central nervous system (CNS), is the hallmark of neuroinflammation in neurodegenerative diseases and other pathological conditions associated with CNS infection.
Das Sulagna, Gupta Malvika, Kaushik Deepak K, Basu Anirban   +3 more
openaire   +3 more sources