Activating transcription factor 6 in the endothelial context. [PDF]
Pulm Pharmacol Ther, 2023 Barabutis N.
europepmc +3 more sources
Activating transcription factor 6 protects against endothelial barrier dysfunction. [PDF]
Cell Signal, 2022 Endothelial hyperpermeability is associated with sepsis and acute respiratory distress syndrome (ARDS). The identification of molecular pathways involved in barrier dysfunction; may reveal promising therapeutic targets to combat ARDS. Unfolded protein response (UPR) is a highly conserved molecular pathway, which ameliorates endoplasmic reticulum stress.
Kubra KT +4 more
europepmc +3 more sources
A permissive epigenetic landscape facilitates distinct transcriptional signatures of activating transcription factor 6 in the liver [PDF]
Genomics, 2021 ABSTRACTProteostatic stress initiates a transcriptional response that is unique to the stress condition, yet the regulatory mechanisms underlying the distinct gene expression patterns observed in stressed cells remains unknown. Using a functional genomic approach, we investigated how activating transcription factor 6 (ATF6), a key transcription factor ...
Anjana Ramdas Nair +4 more
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Transcription factor signal transducer and activator of transcription 6 (STAT6) is an inhibitory factor for adult myogenesis [PDF]
Skeletal Muscle, 2021 AbstractBackgroundThe signal transducer and activator of transcription 6 (STAT6) transcription factor plays a vitally important role in immune cells, where it is activated mainly by interleukin-4 (IL-4). Because IL-4 is an essential cytokine for myotube formation, STAT6 might also be involved in myogenesis as part of IL-4 signaling.
Mitsutoshi Kurosaka +4 more
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Interleukin-4, Interleukin-13, Signal Transducer and Activator of Transcription Factor 6, and Allergic Asthma [PDF]
Current Molecular Medicine, 2008 Interleukin (IL)-4 and IL-13 share many biological activities. To some extent, this is because they both signal via a shared receptor, IL-4Ralpha. Ligation of IL-4Ralpha results in activation of Signal Transducer and Activator of Transcription factor 6 (STAT6) and Insulin Receptor Substrate (IRS) molecules.
Douglas A. Kuperman, Robert P. Schleimer
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Interaction of Maf Transcription Factors with Pax-6 Results in Synergistic Activation of the Glucagon Promoter [PDF]
Journal of Biological Chemistry, 2001 In the endocrine pancreas, alpha-cell-specific expression of the glucagon gene is mediated by DNA-binding proteins that interact with the G1 proximal promoter element. Among these proteins, the paired domain transcription factor Pax-6 has been shown to bind to G1 and to transactivate glucagon gene expression.
Nathalie Planque +6 more
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Expression of Galectin 3 and Activating Transcription Factor 3 in Nigral Dopaminergic Neurons of 6-Hydroxydopamine Induced Parkinsonian Rat Model. [PDF]
In VivoLee EJ +5 more
europepmc +2 more sources
GATA-6 Activates Transcription of Thyroid Transcription Factor-1 [PDF]
Journal of Biological Chemistry, 1999 Thyroid transcription factor-1 (TTF-1) is expressed in respiratory epithelial cells, where it regulates the transcription of target genes expressed in a cell-selective manner. GATA-5 and -6, members of the zinc finger family of transcription factors, are also expressed in various cell types within in the developing lung.
Jeffrey A. Whitsett +2 more
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Sumoylation activates the transcriptional activity of Pax-6, an important transcription factor for eye and brain development [PDF]
Proceedings of the National Academy of Sciences, 2010 Pax-6 is an evolutionarily conserved transcription factor regulating brain and eye development. Four Pax-6 isoforms have been reported previously. Although the longer Pax-6 isoforms (p46 and p48) bear two DNA-binding domains, the paired domain (PD) and the homeodomain (HD), the shorter Pax-6 isoform p32 contains only the HD for DNA binding.
Lan Zhang +21 more
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Endoplasmic Reticulum Stress Induces MUC5AC and MUC5B Expression in Human Nasal Airway Epithelial Cells [PDF]
Clinical and Experimental Otorhinolaryngology, 2019 Objectives Endoplasmic reticulum (ER) stress is known to be associated with inflammatory airway diseases, and three major transmembrane receptors: double-stranded RNA-activated protein kinase-like ER kinase, inositol requiring enzyme 1, and activating ...
Min Han Kim +5 more
doaj +1 more source