Results 31 to 40 of about 470,318 (298)
Journal of Clinical Medicine, 2022 Background: As a member of the Krüppel-like factor (KLFs) family, Krüppel-like factor 6 (KLF6) plays a critical role in regulating key cellular functions. Presently, scholars have proved the important role of KLF6 in the tumorigenesis of certain cancers through a large number of experiments.
Qunli Xiong +8 more
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The function of the protein phosphatase Glc7p in transcription termination, RNA processing and transcriptional regulation of ribosomal protein genes [PDF]
, 2007 Gene transcription in general can be subdivided into three main phases: transcription initiation, elongation and termination. The enzyme that accomplishes transcription of protein coding genes, snRNAs and snoRNAs is RNA polymerase II (RNAP II).
Röck, Salome
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Effect of leucine on endoplasmic reticulum stress induced by early weaning in the liver of piglets
浙江大学学报. 农业与生命科学版, 2018 To investigate the effects of dietary leucine supplementation on endoplasmic reticulum (ER) stress in the liver of early-weaning piglets, we explored the morphology of liver cells, expression pattern of ER stress-associated proteins, and effects on ER ...
FAN Qiwen +4 more
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iScience, 2021 Summary: Although angiogenesis-osteogenesis coupling is important in ankylosing spondylitis (AS), therapeutic agents targeting the vasculature remain elusive.
Mengjun Ma +10 more
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Platelet-derived Growth Factor Induces Interleukin-6 Transcription in Osteoblasts through the Activator Protein-1 Complex and Activating Transcription Factor-2 [PDF]
Journal of Biological Chemistry, 1999 Platelet-derived growth factor (PDGF) BB, a mitogen that stimulates bone resorption, increases the expression of interleukin-6 (IL-6), a cytokine that induces osteoclast recruitment. The mechanisms involved in IL-6 induction by PDGF BB are poorly understood.
N, Franchimont +3 more
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Turnover and function of DNA methylation at transcription factor binding sites [PDF]
, 2014 Cell type identity is largely determined by regulatory networks consistent of various transcription factors. Transcription factor activity requires interaction with DNA and thus critically depends on the accessibility of binding motifs.
Feldmann, Angelika
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Basic and Clinical Neuroscience, 2021 Introduction: Diazinon is one of the most widely-used organophosphate pesticides in the world. This toxin enters the body in various ways and induces oxidative stress in various tissues.
Ali Esfandiarifar +3 more
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The Transcriptional Activator Krüppel-like Factor-6 Is Required for CNS Myelination
PLOS Biology, 2016 Growth factors of the gp130 family promote oligodendrocyte differentiation, and viability, and myelination, but their mechanisms of action are incompletely understood. Here, we show that these effects are coordinated, in part, by the transcriptional activator Krüppel-like factor-6 (Klf6).
Benjamin M. Laitman +23 more
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Activation of interleukin-6 gene expression through the NF-kappa B transcription factor. [PDF]
Molecular and Cellular Biology, 1990 The promoter region of the interleukin-6 (IL-6) gene has a putative NF-kappa B-binding site. We found that a fragment of the IL-6 promoter containing the site specifically binds highly purified NF-kappa B protein and the NF-kappa B protein in nuclear extracts of phorbol ester-induced Jurkat cells.
Libermann, Towia A., Baltimore, David
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POST1/C12ORF49 regulates the SREBP pathway by promoting site-1 protease maturation
Protein & Cell, 2020 Sterol-regulatory element binding proteins (SREBPs) are the key transcriptional regulators of lipid metabolism. The activation of SREBP requires translocation of the SREBP precursor from the endoplasmic reticulum to the Golgi, where it is sequentially ...
Jian Xiao +9 more
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