Results 31 to 40 of about 692,400 (286)

ORMDL3 Functions as a Negative Regulator of Antigen-Mediated Mast Cell Activation via an ATF6-UPR-Autophagy–Dependent Pathway

Frontiers in Immunology, 2021
Antigen (Ag)-mediated mast cell activation plays a critical role in the immunopathology of IgE-dependent allergic diseases. Restraining the signaling cascade that regulates the release of mast cell-derived inflammatory mediators is an attractive ...
Jia Li, Md Ashik Ullah, Hongping Jin, Yuting Liang, Lihui Lin, Juan Wang, Xia Peng, Huanjin Liao, Yanning Li, Yiqin Ge, Li Li   +10 more
doaj   +1 more source

Regression/eradication of gliomas in mice by a systemically-deliverable ATF5 dominant-negative peptide. [PDF]

, 2016
Malignant gliomas have poor prognosis and urgently require new therapies. Activating Transcription Factor 5 (ATF5) is highly expressed in gliomas, and interference with its expression/function precipitates targeted glioma cell apoptosis in vitro and in ...
Angelastro, James, Arias, Angelo, Cates, Charles, Cayanan, Geraldine, Fung, Jennifer, Greene, Lloyd, Karpel-Massler, Georg, Lamé, Michael, Nakayama Wong, Lynn, Rowland, Douglas, Sidorov, Maxim, Siegelin, Markus   +11 more
core   +2 more sources

Krüppel-like Factor 6 Suppresses the Progression of Pancreatic Cancer by Upregulating Activating Transcription Factor 3

Journal of Clinical Medicine, 2022
Background: As a member of the Krüppel-like factor (KLFs) family, Krüppel-like factor 6 (KLF6) plays a critical role in regulating key cellular functions. Presently, scholars have proved the important role of KLF6 in the tumorigenesis of certain cancers through a large number of experiments.
Qunli Xiong, Zhiwei Zhang, Yang Yang, Yongfeng Xu, Ying Zhou, Su Zhang, Jinlu Liu, Ying Zheng, Qing Zhu   +8 more
openaire   +2 more sources

Inhibition of IRE1α-mediated XBP1 mRNA cleavage by XBP1 reveals a novel regulatory process during the unfolded protein response [PDF]

, 2017
Background: The mammalian endoplasmic reticulum (ER) continuously adapts to the cellular secretory load by the activation of an unfolded protein response (UPR).
Bulleid, Neil J., Cain, Katharine, Chalmers, Fiona, Sweeney, Bernadette, van Lith, Marcel   +4 more
core   +2 more sources

Effect of leucine on endoplasmic reticulum stress induced by early weaning in the liver of piglets

浙江大学学报. 农业与生命科学版, 2018
To investigate the effects of dietary leucine supplementation on endoplasmic reticulum (ER) stress in the liver of early-weaning piglets, we explored the morphology of liver cells, expression pattern of ER stress-associated proteins, and effects on ER ...
FAN Qiwen, CHEN Lingli, ZHAO Li, SHI Min, YAN Xianghua   +4 more
doaj   +1 more source

ATF6 aggravates angiogenesis-osteogenesis coupling during ankylosing spondylitis by mediating FGF2 expression in chondrocytes

iScience, 2021
Summary: Although angiogenesis-osteogenesis coupling is important in ankylosing spondylitis (AS), therapeutic agents targeting the vasculature remain elusive.
Mengjun Ma, Hongyu Li, Peng Wang, Wen Yang, Rujia Mi, Jiahao Zhuang, Yuhang Jiang, Yixuan Lu, Xin Shen, Yanfeng Wu, Huiyong Shen   +10 more
doaj   +1 more source

The participation of activating transcription factor 6 alpha, ATF6α, in Alzheimer’s disease [PDF]

Alzheimers Dement
AbstractBackgroundAlzheimer’s disease (AD) is the leading cause of dementia in elderly humans worldwide. More than 40 million people currently suffer from AD, and this prevalence tends to increase considerably in the coming decades due to increased longevity.
Chauvet M, Isaac A, Lourenco M.
europepmc   +2 more sources

Activating Transcription Factor 4 Links Metabolic Stress to Interleukin-6 Expression in Macrophages [PDF]

Diabetes, 2013
Chronic inflammation is a molecular element of the metabolic syndrome and type 2 diabetes. Saturated fatty acids (SFAs) are considered to be an important proinflammatory factor. However, it is still incompletely understood how SFAs induce proinflammatory cytokine expression. Hereby we report that activating transcription factor (ATF) 4, a transcription
Yorihiro, Iwasaki, Takayoshi, Suganami, Rumi, Hachiya, Ibuki, Shirakawa, Misa, Kim-Saijo, Miyako, Tanaka, Miho, Hamaguchi, Takako, Takai-Igarashi, Michikazu, Nakai, Yoshihiro, Miyamoto, Yoshihiro, Ogawa   +10 more
openaire   +2 more sources

The Effect of Resistance Training and Berberine Chloride on the Apoptosis-related Unfolded Protein Response Signaling Pathway in the Hippocampus of Diazinon-poisoned Rats

Basic and Clinical Neuroscience, 2021
Introduction: Diazinon is one of the most widely-used organophosphate pesticides in the world. This toxin enters the body in various ways and induces oxidative stress in various tissues.
Ali Esfandiarifar, Mohammad Ali Azarbayjani, Maghsood Peeri, Seyed Behnamedin Jameie   +3 more
doaj  

POST1/C12ORF49 regulates the SREBP pathway by promoting site-1 protease maturation

Protein & Cell, 2020
Sterol-regulatory element binding proteins (SREBPs) are the key transcriptional regulators of lipid metabolism. The activation of SREBP requires translocation of the SREBP precursor from the endoplasmic reticulum to the Golgi, where it is sequentially ...
Jian Xiao, Yanni Xiong, Liu-Ting Yang, Ju-Qiong Wang, Zi-Mu Zhou, Le-Wei Dong, Xiong-Jie Shi, Xiaolu Zhao, Jie Luo, Bao-Liang Song   +9 more
doaj   +1 more source