Activating transcription factor 6 in the endothelial context. [PDF]
Pulm Pharmacol Ther, 2023 Barabutis N.
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Activating transcription factor 6 protects against endothelial barrier dysfunction. [PDF]
Cell Signal, 2022 Endothelial hyperpermeability is associated with sepsis and acute respiratory distress syndrome (ARDS). The identification of molecular pathways involved in barrier dysfunction; may reveal promising therapeutic targets to combat ARDS. Unfolded protein response (UPR) is a highly conserved molecular pathway, which ameliorates endoplasmic reticulum stress.
Kubra KT +4 more
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Transcription factor signal transducer and activator of transcription 6 (STAT6) is an inhibitory factor for adult myogenesis [PDF]
Skeletal Muscle, 2021 AbstractBackgroundThe signal transducer and activator of transcription 6 (STAT6) transcription factor plays a vitally important role in immune cells, where it is activated mainly by interleukin-4 (IL-4). Because IL-4 is an essential cytokine for myotube formation, STAT6 might also be involved in myogenesis as part of IL-4 signaling.
Mitsutoshi Kurosaka +4 more
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A permissive epigenetic landscape facilitates distinct transcriptional signatures of activating transcription factor 6 in the liver [PDF]
Genomics, 2021 ABSTRACTProteostatic stress initiates a transcriptional response that is unique to the stress condition, yet the regulatory mechanisms underlying the distinct gene expression patterns observed in stressed cells remains unknown. Using a functional genomic approach, we investigated how activating transcription factor 6 (ATF6), a key transcription factor ...
Anjana Ramdas Nair +4 more
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GATA-6 Activates Transcription of Thyroid Transcription Factor-1 [PDF]
Journal of Biological Chemistry, 1999 Thyroid transcription factor-1 (TTF-1) is expressed in respiratory epithelial cells, where it regulates the transcription of target genes expressed in a cell-selective manner. GATA-5 and -6, members of the zinc finger family of transcription factors, are also expressed in various cell types within in the developing lung.
J R, Shaw-White +2 more
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Sirtuin 6 promotes eosinophil differentiation by activating GATA‐1 transcription factor
Aging Cell, 2021 AbstractThere is evidence emerging that exposure to cold temperatures enhances alternative activation of macrophages in white adipose tissue (WAT), which promotes adipocyte beiging and adaptive thermogenesis. Although we recently reported that NAD+‐dependent deacetylase sirtuin 6 (Sirt6) drives alternatively activated (M2) macrophage polarization, the ...
In Hyuk Bang +5 more
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Heat Shock Transcription Factor 1 Inhibits Expression of IL-6 through Activating Transcription Factor 3 [PDF]
The Journal of Immunology, 2009 Abstract The febrile response is a complex physiological reaction to disease, including a cytokine-mediated increase in body temperature and the activation of inflammatory systems. Fever has beneficial roles in terms of disease prognosis, partly by suppressing the expression of inflammatory cytokines.
Ryosuke, Takii +10 more
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Activating Transcription Factor 6 Mediates Inflammatory Signals in Intestinal Epithelial Cells Upon Endoplasmic Reticulum Stress. [PDF]
Gastroenterology, 2020 BACKGROUND & AIMS: Excess and unresolved endoplasmic reticulum (ER) stress in intestinal epithelial cells (IECs) promotes intestinal inflammation. Activating transcription factor 6 (ATF6) is one of the signaling mediators of ER stress. We studied the pathways that regulate ATF6 and its role for inflammation in IECs.
Stengel ST +27 more
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Endoplasmic Reticulum Stress Induces MUC5AC and MUC5B Expression in Human Nasal Airway Epithelial Cells [PDF]
Clinical and Experimental Otorhinolaryngology, 2019 Objectives Endoplasmic reticulum (ER) stress is known to be associated with inflammatory airway diseases, and three major transmembrane receptors: double-stranded RNA-activated protein kinase-like ER kinase, inositol requiring enzyme 1, and activating ...
Min Han Kim +5 more
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The Transcriptional Activator Hepatocyte Nuclear Factor 6 Regulates Liver Gene Expression [PDF]
Molecular and Cellular Biology, 1996 The hepatocyte nuclear factor 3(alpha) (HNF-3(alpha)), -3(beta), and -3(gamma) proteins share homology in the winged-helix/fork head DNA binding domain and mediate hepatocyte-enriched transcription of numerous genes whose expression is necessary for organ function. In this work, we identify a liver-enriched transcription factor, HNF-6, which recognizes
U, Samadani, R H, Costa
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