Activating transcription factor 6 derepression mediates neuroprotection in Huntington disease. [PDF]
J Clin Invest, 2016 Deregulated protein and Ca2+ homeostasis underlie synaptic dysfunction and neurodegeneration in Huntington disease (HD); however, the factors that disrupt homeostasis are not fully understood. Here, we determined that expression of downstream regulatory element antagonist modulator (DREAM), a multifunctional Ca2+-binding protein, is reduced in murine ...
Naranjo JR +18 more
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Hypertrophic Growth Control by Activating Transcription Factor 6 in the Neonatal and Adult Heart [PDF]
, 2022 The integrity of the proteome is essential for optimal cardiac function. Proteome integrity is maintained by the proteostasis network, which regulates cellular protein synthesis, folding, and degradation. An insufficient capacity of the proteostasis network results in the accumulation of toxic misfolded proteins, which impairs cellular function and can
Hofmann, Christoph
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Activating transcription factor 6 in the endothelial context. [PDF]
Pulm Pharmacol Ther, 2023 Barabutis N.
europepmc +3 more sources
Activating transcription factor 6 protects against endothelial barrier dysfunction. [PDF]
Cell Signal, 2022 Endothelial hyperpermeability is associated with sepsis and acute respiratory distress syndrome (ARDS). The identification of molecular pathways involved in barrier dysfunction; may reveal promising therapeutic targets to combat ARDS. Unfolded protein response (UPR) is a highly conserved molecular pathway, which ameliorates endoplasmic reticulum stress.
Kubra KT +4 more
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Activating Transcription Factor 6 (ATF6): Structure, Interactions and Inhibition
The endoplasmic reticulum (ER) is a very important organelle in cellular activity, especially in protein biosynthesis, folding, and quality control. In situations where there is stress in the endoplasmic reticulum and there is accumulation of improperly folded or unfolded proteins, cells induce the Unfolded Protein Response (UPR) in order to restore ...
Narayanan, Sethuraman
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Transcription factor signal transducer and activator of transcription 6 (STAT6) is an inhibitory factor for adult myogenesis [PDF]
Skeletal Muscle, 2021 AbstractBackgroundThe signal transducer and activator of transcription 6 (STAT6) transcription factor plays a vitally important role in immune cells, where it is activated mainly by interleukin-4 (IL-4). Because IL-4 is an essential cytokine for myotube formation, STAT6 might also be involved in myogenesis as part of IL-4 signaling.
Mitsutoshi Kurosaka +4 more
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A permissive epigenetic landscape facilitates distinct transcriptional signatures of activating transcription factor 6 in the liver [PDF]
Genomics, 2021 ABSTRACT Proteostatic stress initiates a transcriptional response that is unique to the stress condition, yet the regulatory mechanisms underlying the distinct gene expression patterns observed in stressed cells remains unknown. Using a functional genomic approach, we investigated how activating transcription factor 6 (ATF6), a key ...
Anjana Ramdas Nair +4 more
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GATA-6 Activates Transcription of Thyroid Transcription Factor-1 [PDF]
Journal of Biological Chemistry, 1999 Thyroid transcription factor-1 (TTF-1) is expressed in respiratory epithelial cells, where it regulates the transcription of target genes expressed in a cell-selective manner. GATA-5 and -6, members of the zinc finger family of transcription factors, are also expressed in various cell types within in the developing lung.
J R, Shaw-White +2 more
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Sumoylation activates the transcriptional activity of Pax-6, an important transcription factor for eye and brain development [PDF]
Proceedings of the National Academy of Sciences, 2010 Pax-6 is an evolutionarily conserved transcription factor regulating brain and eye development. Four Pax-6 isoforms have been reported previously. Although the longer Pax-6 isoforms (p46 and p48) bear two DNA-binding domains, the paired domain (PD) and the homeodomain (HD), the shorter Pax-6 isoform p32 contains only the HD for DNA binding.
Qin, Yan +15 more
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The Forkhead Transcription Factor AFX Activates Apoptosis by Induction of the BCL-6 Transcriptional Repressor [PDF]
Journal of Biological Chemistry, 2002 The activation of the AKT/protein kinase B kinases by mutation of the PTEN lipid phosphatase results in enhanced survival of a diversity of tumors. This resistance to apoptosis is partly accomplished by the inhibition of genetic programs induced by a subfamily of forkhead transcription factors including AFX.
Tracy Tzu-Ling, Tang +6 more
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