Results 21 to 30 of about 692,400 (286)

Up-Regulation of Activating Transcription Factor 3 in Human Fibroblasts Inhibits Melanoma Cell Growth and Migration Through a Paracrine Pathway

Frontiers in Oncology, 2020
The treatment of melanoma has remained a difficult challenge. Targeting the tumor stroma has recently attracted attention for developing novel strategies for melanoma therapy.
Tingjian Zu, Tingjian Zu, Jie Wen, Jie Wen, Lin Xu, Lin Xu, Lin Xu, Hui Li, Jun Mi, Jun Mi, Hui Li, Cord Brakebusch, David E. Fisher, Xunwei Wu, Xunwei Wu, Xunwei Wu   +15 more
doaj   +1 more source

Sumoylation activates the transcriptional activity of Pax-6, an important transcription factor for eye and brain development [PDF]

Proceedings of the National Academy of Sciences, 2010
Pax-6 is an evolutionarily conserved transcription factor regulating brain and eye development. Four Pax-6 isoforms have been reported previously. Although the longer Pax-6 isoforms (p46 and p48) bear two DNA-binding domains, the paired domain (PD) and the homeodomain (HD), the shorter Pax-6 isoform p32 contains only the HD for DNA binding.
Qin, Yan, Lili, Gong, Mi, Deng, Lan, Zhang, Shuming, Sun, Jiao, Liu, Haili, Ma, Dan, Yuan, Pei-Chao, Chen, Xiaohui, Hu, Jinping, Liu, Jichao, Qin, Ling, Xiao, Xiao-Qin, Huang, Jian, Zhang, David Wan-Cheng, Li   +15 more
openaire   +2 more sources

Activating transcription factor 6 promotes proliferation, migration and invasion of PC3 human prostate cancer cells through Hippo-YAP signaling pathway

陆军军医大学学报, 2023
Objective To investigate the effects of activating transcription factor 6 (ATF6) on the proliferation, migration and invasion of prostate cancer PC3 cells.
LIU Hengchuan, YANG Zongke, LIU Qingyuan, ZHANG Jindong, ZHU Huixuan, WANG Delin   +5 more
doaj   +1 more source

Platelet-derived Growth Factor Induces Interleukin-6 Transcription in Osteoblasts through the Activator Protein-1 Complex and Activating Transcription Factor-2 [PDF]

Journal of Biological Chemistry, 1999
Platelet-derived growth factor (PDGF) BB, a mitogen that stimulates bone resorption, increases the expression of interleukin-6 (IL-6), a cytokine that induces osteoclast recruitment. The mechanisms involved in IL-6 induction by PDGF BB are poorly understood.
N, Franchimont, D, Durant, S, Rydziel, E, Canalis   +3 more
openaire   +2 more sources

ETS variant transcription factor 6 enhances oxidized low-density lipoprotein-induced inflammatory response in atherosclerotic macrophages via activating NF-κB signaling

International Journal of Immunopathology and Pharmacology, 2022
Objectives : Macrophages play a critical role in atherosclerosis by contributing to plaque development, local inflammation, and thrombosis. Elucidation of the molecular cascades in atherosclerotic macrophages is important for preventing and treating ...
Xiaofang Xiong, Zheng Yan, Wei Jiang, Xuejun Jiang   +3 more
doaj   +1 more source

PRP-1, a toll-like receptor ligand, upregulates the unfolded protein response in human chondrosarcoma cells

Cancer Treatment and Research Communications, 2022
Background: Previous studies showed that proline-rich polypeptide (PRP-1) is a ligand for innate immunity toll-like receptors (TLR), and an inhibitor of the mammalian target of rapamycin complex 1 (mTORC1) which induces the death of chondrosarcoma cancer
Karina Galoian, Victoria Dahl, Andres Perez, Carina Denny, Beatrice Becker, Anil Sedani, Alexandra Moran, Daniel Martinez, Aaron Hoyt, Jeffrey Brown   +9 more
doaj   +1 more source

The Forkhead Transcription Factor AFX Activates Apoptosis by Induction of the BCL-6 Transcriptional Repressor [PDF]

Journal of Biological Chemistry, 2002
The activation of the AKT/protein kinase B kinases by mutation of the PTEN lipid phosphatase results in enhanced survival of a diversity of tumors. This resistance to apoptosis is partly accomplished by the inhibition of genetic programs induced by a subfamily of forkhead transcription factors including AFX.
Tracy Tzu-Ling, Tang, Donald, Dowbenko, Amanda, Jackson, Lisa, Toney, David A, Lewin, Alexander L, Dent, Laurence A, Lasky   +6 more
openaire   +2 more sources

Pre-pregnancy maternal obesity associates with endoplasmic reticulum stress in human umbilical vein endothelium [PDF]

, 2018
Obesity associates with the endoplasmic reticulum (ER) stress-induced endothelial dysfunction. Pregnant women with pre-pregnancy maternal obesity (PGMO) may transfer this potential risk to their offspring; however, whether ER stress occurs and associates
Farías, Marcelo, Pardo, Fabián, Silva, Luis, Sobrevia, Luis, Subiabre, Mario, Sáez, Pablo J., Toledo, Fernando, Villalobos-Labra, Roberto, Westermeier, Francisco   +8 more
core   +2 more sources

The transcription factor ATF5: role in cellular differentiation, stress responses, and cancer. [PDF]

, 2017
Activating transcription factor 5 (ATF5) is a cellular prosurvival transcription factor within the basic leucine zipper (bZip) family that is involved in cellular differentiation and promotes cellular adaptation to stress.
Angelastro, James M, Sears, Thomas K
core   +2 more sources

Activation of interleukin-6 gene expression through the NF-kappa B transcription factor. [PDF]

Molecular and Cellular Biology, 1990
The promoter region of the interleukin-6 (IL-6) gene has a putative NF-kappa B-binding site. We found that a fragment of the IL-6 promoter containing the site specifically binds highly purified NF-kappa B protein and the NF-kappa B protein in nuclear extracts of phorbol ester-induced Jurkat cells.
Libermann, Towia A., Baltimore, David
openaire   +3 more sources