Results 21 to 30 of about 470,318 (298)

Heat Shock Transcription Factor 1 Inhibits Expression of IL-6 through Activating Transcription Factor 3 [PDF]

The Journal of Immunology, 2009
Abstract The febrile response is a complex physiological reaction to disease, including a cytokine-mediated increase in body temperature and the activation of inflammatory systems. Fever has beneficial roles in terms of disease prognosis, partly by suppressing the expression of inflammatory cytokines. However, the molecular mechanisms
Ryosuke, Takii, Sachiye, Inouye, Mitsuaki, Fujimoto, Tamami, Nakamura, Toyohide, Shinkawa, Ramachandran, Prakasam, Ke, Tan, Naoki, Hayashida, Hitoshi, Ichikawa, Tsonwin, Hai, Akira, Nakai   +10 more
openaire   +2 more sources

Sirtuin 6 promotes eosinophil differentiation by activating GATA‐1 transcription factor

Aging Cell, 2021
AbstractThere is evidence emerging that exposure to cold temperatures enhances alternative activation of macrophages in white adipose tissue (WAT), which promotes adipocyte beiging and adaptive thermogenesis. Although we recently reported that NAD+‐dependent deacetylase sirtuin 6 (Sirt6) drives alternatively activated (M2) macrophage polarization, the ...
In Hyuk Bang, Dami Park, Youngyi Lee, Hwangeui Cho, Byung‐Hyun Park, Eun Ju Bae   +5 more
openaire   +2 more sources

Krüppel-like factor 6 is a transcriptional activator of autophagy in acute liver injury [PDF]

Scientific Reports, 2017
AbstractKrüppel-like factor 6 (KLF6) is a transcription factor and tumor suppressor. We previously identified KLF6 as mediator of hepatocyte glucose and lipid homeostasis. The loss or reduction of KLF6 is linked to the progression of hepatocellular carcinoma, but its contribution to liver regeneration and repair in acute liver injury are lacking so far.
Sydor, Svenja, Manka, Paul, Best, Jan, Jafoui, Sami, Sowa, Jan-Peter, Zoubek, Miguel Eugenio, Hernandez-Gea, Virginia, Cubero, Francisco Javier, Kälsch, Julia, Vetter, Diana, Fiel, Maria Isabel, Hoshida, Yujin, Bian, C Billie, Nelson, Leonard J, Moshage, Han, Faber, Klaas Nico, Paul, Andreas, Baba, Hideo A, Gerken, Guido, Friedman, Scott L, Canbay, Ali, Bechmann, Lars P   +21 more
openaire   +6 more sources

Activating transcription factor 6 promotes proliferation, migration and invasion of PC3 human prostate cancer cells through Hippo-YAP signaling pathway

陆军军医大学学报, 2023
Objective To investigate the effects of activating transcription factor 6 (ATF6) on the proliferation, migration and invasion of prostate cancer PC3 cells.
LIU Hengchuan, YANG Zongke, LIU Qingyuan, ZHANG Jindong, ZHU Huixuan, WANG Delin   +5 more
doaj   +1 more source

ETS variant transcription factor 6 enhances oxidized low-density lipoprotein-induced inflammatory response in atherosclerotic macrophages via activating NF-κB signaling

International Journal of Immunopathology and Pharmacology, 2022
Objectives : Macrophages play a critical role in atherosclerosis by contributing to plaque development, local inflammation, and thrombosis. Elucidation of the molecular cascades in atherosclerotic macrophages is important for preventing and treating ...
Xiaofang Xiong, Zheng Yan, Wei Jiang, Xuejun Jiang   +3 more
doaj   +1 more source

PRP-1, a toll-like receptor ligand, upregulates the unfolded protein response in human chondrosarcoma cells

Cancer Treatment and Research Communications, 2022
Background: Previous studies showed that proline-rich polypeptide (PRP-1) is a ligand for innate immunity toll-like receptors (TLR), and an inhibitor of the mammalian target of rapamycin complex 1 (mTORC1) which induces the death of chondrosarcoma cancer
Karina Galoian, Victoria Dahl, Andres Perez, Carina Denny, Beatrice Becker, Anil Sedani, Alexandra Moran, Daniel Martinez, Aaron Hoyt, Jeffrey Brown   +9 more
doaj   +1 more source

Lipopolysaccharide induces nitric oxide synthase expression and platelet-activating factor increases nitric oxide production in human fetal membranes in culture [PDF]

, 2004
Platelet-activating factor and nitric oxide may be involved in the initiation of human labour as inflammatory mediators. The aim of this study was to test whether platelet-activating factor and lipopolysaccharide were able to induce nitric oxide synthase
Damian J Murphy, Dunmore, Simon J., Murphy Damian J, Carson Ray J, Rodrigo, Nalinda, Seyffarth Gunter, Nelson, Paul N., Dunmore Simon J, Simon J Dunmore, Nalinda Rodrigo, Carson, Ray J., Seyffarth, Gunther, Rodrigo Nalinda, Paul N Nelson, Murphy, Damian J., Nelson Paul N, Gunter Seyffarth, Ray J Carson   +17 more
core   +1 more source

The Transcriptional Activator Hepatocyte Nuclear Factor 6 Regulates Liver Gene Expression [PDF]

Molecular and Cellular Biology, 1996
The hepatocyte nuclear factor 3(alpha) (HNF-3(alpha)), -3(beta), and -3(gamma) proteins share homology in the winged-helix/fork head DNA binding domain and mediate hepatocyte-enriched transcription of numerous genes whose expression is necessary for organ function. In this work, we identify a liver-enriched transcription factor, HNF-6, which recognizes
U, Samadani, R H, Costa
openaire   +2 more sources

The participation of activating transcription factor 6 alpha, ATF6α, in Alzheimer’s disease [PDF]

Alzheimers Dement
AbstractBackgroundAlzheimer’s disease (AD) is the leading cause of dementia in elderly humans worldwide. More than 40 million people currently suffer from AD, and this prevalence tends to increase considerably in the coming decades due to increased longevity.
Chauvet M, Isaac A, Lourenco M.
europepmc   +2 more sources

ORMDL3 Functions as a Negative Regulator of Antigen-Mediated Mast Cell Activation via an ATF6-UPR-Autophagy–Dependent Pathway

Frontiers in Immunology, 2021
Antigen (Ag)-mediated mast cell activation plays a critical role in the immunopathology of IgE-dependent allergic diseases. Restraining the signaling cascade that regulates the release of mast cell-derived inflammatory mediators is an attractive ...
Jia Li, Md Ashik Ullah, Hongping Jin, Yuting Liang, Lihui Lin, Juan Wang, Xia Peng, Huanjin Liao, Yanning Li, Yiqin Ge, Li Li   +10 more
doaj   +1 more source