Results 41 to 50 of about 692,400 (286)

Regulation of polarised growth in fungi [PDF]

, 2008
Polarised growth in fungi occurs through the delivery of secretory vesicles along tracks formed by cytoskeletal elements to specific sites on the cell surface where they dock with a multiprotein structure called the exocyst before fusing with the ...
Adamo, Adamo, Adams, Akashi, Ayad-Durieux, Bachewich, Bartnicki-Garcia, Bartnicki-Garcia, Bassilana, Bassilana, Bassilana, Behrens, Berman, Bidlingmaier, Bose, Boyce, Boyce, Boyce, Boyd, Brown, Caviston, Chant, Chapa y Lazo, Collinge, Colman-Lerner, Court, Crampin, Cvrckova, Dong, Drgonova, Dunkler, Feng, Finger, France, Gao, Girbardt, Gladfelter, Goehring, Gorovits, Gulli, Guo, Harris, Harris, Hartwell, Hergovich, Hou, Hou, Irazoqui, Jin, Karnoub, Knechtle, Kohno, Konzack, Kron, Leberer, Leberer, Leberer, Leonhard, Lew, Li, Liu, Loeb, Loeb, Longtine, Mahlert, Mata, McCollum, McCusker, Medkova, Mehta, Mendenhall, Nelson, Nonaka, Novick, Pan, Park, Pearson, Peter, Peter E. Sudbery, Philippsen, Punt, Qadota, Racki, Read, Santangelo, Schmidt, Seiler, Seiler, Sinha, Smith, Soll, Stevenson, Sudbery, Sudbery, Sudbery, Tamaskovic, Tanaka, Tcheperegine, Trinci, Verde, Versele, Virag, Virag, Walton, Walworth, Wedlich-Soldner, Wedlich-Soldner, Wendland, Wu, Yarden, Zhang, Zheng, Zheng   +112 more
core   +1 more source

Angiotensin II Induces Interleukin-6 Transcription in Vascular Smooth Muscle Cells Through Pleiotropic Activation of Nuclear Factor-κB Transcription Factors [PDF]

Circulation Research, 1999
Abstract —Interleukin-6 (IL-6) is a multifunctional cytokine expressed by angiotensin II (Ang II)-stimulated vascular smooth muscle cells (VSMCs) that functions as an autocrine growth factor. In this study, we analyze the mechanism for Ang II-inducible IL-6 expression in quiescent rat VSMCs.
Y, Han, M S, Runge, A R, Brasier
openaire   +2 more sources

A pilot study on gene expression of endoplasmic reticulum unfolded protein response in chronic kidney disease

Biochemistry and Biophysics Reports, 2020
Background: Chronic kidney disease (CKD) is a worldwide public health problem due to its increasing prevalence worldwide. Endoplasmic reticulum (ER) stress has been shown to play a role in the pathogenesis of various renal diseases in humans. It leads to
Rasha G. Mostafa, Abd El-Aleem Hassan Abd El-Aleem, Eman Abdella Mahmoud Fouda, Fardous Rabea Ahmed Taha, Khaled Mohamed Amin Elzorkany   +4 more
doaj   +1 more source

The molecular basis of T cell acute lymphoblastic leukemia [PDF]

, 2012
T cell acute lymphoblastic leukemias (T-ALLs) arise from the malignant transformation of hematopoietic progenitors primed toward T cell development, as result of a multistep oncogenic process involving constitutive activation of NOTCH signaling and ...
Adolfo Ferrando, Bash, Bash, Chen, Condorelli, Dube, Fisch, Hagemeijer, Hebert, Ho, Kelliher, Kikuchi, Larson, Lu, McGuire, McGuire, Nagel, Ntziachristos, Ntziachristos, Ono, Pieter Van Vlierberghe, Royer-Pokora, Rubnitz, van Grotel   +23 more
core   +1 more source

Krüppel-like factor 6 is a transcriptional activator of autophagy in acute liver injury [PDF]

Scientific Reports, 2017
AbstractKrüppel-like factor 6 (KLF6) is a transcription factor and tumor suppressor. We previously identified KLF6 as mediator of hepatocyte glucose and lipid homeostasis. The loss or reduction of KLF6 is linked to the progression of hepatocellular carcinoma, but its contribution to liver regeneration and repair in acute liver injury are lacking so far.
Sydor, Svenja, Manka, Paul, Best, Jan, Jafoui, Sami, Sowa, Jan-Peter, Zoubek, Miguel Eugenio, Hernandez-Gea, Virginia, Cubero, Francisco Javier, Kälsch, Julia, Vetter, Diana, Fiel, Maria Isabel, Hoshida, Yujin, Bian, C Billie, Nelson, Leonard J, Moshage, Han, Faber, Klaas Nico, Paul, Andreas, Baba, Hideo A, Gerken, Guido, Friedman, Scott L, Canbay, Ali, Bechmann, Lars P   +21 more
openaire   +5 more sources

Expression of markers of endoplasmic reticulum stress-induced apoptosis in the placenta of women with early and late onset severe pre-eclampsia

Taiwanese Journal of Obstetrics & Gynecology, 2015
Objectives: Endoplasmic reticulum (ER) stress-induced apoptosis has been implicated in severe pre-eclampsia (SPE) and is characterized by the activation of three signaling pathways: PKR-like endoplasmic reticulum kinase (PERK), activating transcription ...
Jinhua Fu, Long Zhao, Li Wang, Xiaohe Zhu   +3 more
doaj   +1 more source

Hedgehog pathway dysregulation contributes to the pathogenesis of human gastrointestinal stromal tumors via GLI-mediated activation of KIT expression. [PDF]

, 2016
Gastrointestinal stromal tumors (GIST) arise within the interstitial cell of Cajal (ICC) lineage due to activating KIT/PDGFRA mutations. Both ICC and GIST possess primary cilia (PC), which coordinate PDGFRA and Hedgehog signaling, regulators of ...
Bardsley, Michael R, Burgoyne, Adam M, Chan, Jonathan C, Chmielecki, Juliann, Gao, Fei, Harismendy, Olivier, Kendrick, Michael L, Lee, Tracy E, Leonard, Stephanie Y, Mao, Junhao, Morosini, Deborah, Ordog, Tamas, Ross, Jeffrey S, Shi, Eileen, Sicklick, Jason K, Siena, Martina De, Syed, Sabriya A, Tang, Chih-Min, Wang, Kai   +18 more
core   +2 more sources

A model for how signal duration can determine distinct outcomes of gene transcription programs. [PDF]

PLoS ONE, 2012
The reason why IL-6 induces a pro-inflammatory response, while IL-10 induces an anti-inflammatory response, despite both cytokines activating the same transcription factor, STAT3, is not well understood.
Kevin D Fowler, Vijay K Kuchroo, Arup K Chakraborty   +2 more
doaj   +1 more source

African Swine Fever Virus K205R Induces ER Stress and Consequently Activates Autophagy and the NF-κB Signaling Pathway

Viruses, 2022
African swine fever virus (ASFV) is responsible for enormous economic losses in the global swine industry. The ASFV genome encodes approximate 160 proteins, most of whose functions remain largely unknown.
Qi Wang, Luyu Zhou, Jiang Wang, Dan Su, Dahua Li, Yongkun Du, Guoyu Yang, Gaiping Zhang, Beibei Chu   +8 more
doaj   +1 more source

Human collagen Krox up-regulates type I collagen expression in normal and scleroderma fibroblasts through interaction with Sp1 and Sp3 transcription factors. [PDF]

, 2007
Despite several investigations, the transcriptional mechanisms that regulate the expression of both type I collagen genes (COL1A1 and COL1A2) in either physiological or pathological situations, such as scleroderma, are not completely known.
Beauchef, Gallic, Chadjichristos, Christos, Galéra, Philippe, Jimenez, Sergio A., Korn, Joseph, Kypriotou, Magdalini, Maquart, François-Xavier, Oddos, Thierry, Pujol, Jean-Pierre, Renard, Emmanuelle, Von Stetten, Otto, Widom, Russell   +11 more
core   +3 more sources