Results 51 to 60 of about 470,318 (298)

Activating transcription factor (ATF) 6 upregulates cystathionine β synthetase (CBS) expression and hydrogen sulfide (H2S) synthesis to ameliorate liver metabolic damage

European Journal of Medical Research, 2023
Activating transcription factor 6 (ATF6) is an endoplasmic reticulum stress responsive gene. We previously reported that conditional knockout of hepatic ATF6 exacerbated liver metabolic damage by repressing autophagy through mTOR pathway.
Bingzi Dong, Ying Sun, Bingfei Cheng, Yu Xue, Wei Li, Xiaofang Sun   +5 more
doaj   +1 more source

Function of the upstream activating factor in chromatin structure organization and transcriptional regulation at the yeast ribosomal DNA

, 2010
Chromatin is the template of all processes involved in DNA metabolism in the eukaryotic cell. Accordingly, chromatin is a dynamic structure which changes in its composition and posttranslational modification correlating with the functional state of a ...
Götze, Hannah
core   +1 more source

A local regulatory network around three NAC transcription factors in stress responses and senescence in Arabidopsis leaves [PDF]

, 2013
A model is presented describing the gene regulatory network surrounding three similar NAC transcription factors that have roles in Arabidopsis leaf senescence and stress responses. ANAC019, ANAC055 and ANAC072 belong to the same clade of NAC domain genes
Cooke, Emma J., Jonathan D. Moore, Laura Bowden, Katherine J. Denby, Hickman, Richard J., Beynon, Jim, Richard Hickman, Findlay Bewicke‐Copley, David L. Wild, Vicky Buchanan‐Wollaston, Jim Beynon, Jackson, Alison C., Denby, Katherine J., Mead, A. (Andrew), Penfold, Christopher A., Bowden, Laura, Andrew Mead, Wild, David L., Christopher A. Penfold, Moore, Jonathan D., Emily Breeze, Breeze, Emily, Alison Jackson, Sascha Ott, Buchanan-Wollaston, Vicky, Peijun Zhang, Emma Cooke, Hill, C., Zhang, Peijun, Bewicke-Copley, Findlay, Claire Hill, Ott, Sascha   +31 more
core   +1 more source

Endoplasmic Reticulum Stress Induced Proliferation Remains Intact in Aging Mouse β-Cells

Frontiers in Endocrinology, 2021
Aging is associated with loss of proliferation of the insulin-secreting β-cell, a possible contributing factor to the increased prevalence of type 2 diabetes in the elderly.
Jarin T. Snyder, Christine Darko, Rohit B. Sharma, Laura C. Alonso   +3 more
doaj   +1 more source

Interaction of Maf Transcription Factors with Pax-6 Results in Synergistic Activation of the Glucagon Promoter [PDF]

Journal of Biological Chemistry, 2001
In the endocrine pancreas, alpha-cell-specific expression of the glucagon gene is mediated by DNA-binding proteins that interact with the G1 proximal promoter element. Among these proteins, the paired domain transcription factor Pax-6 has been shown to bind to G1 and to transactivate glucagon gene expression.
N, Planque, L, Leconte, F M, Coquelle, S, Benkhelifa, P, Martin, M P, Felder-Schmittbuhl, S, Saule   +6 more
openaire   +2 more sources

The ATF6-Met [67] Val substitution is associated with increased plasma cholesterol levels

, 2009
Objective— Activating transcription factor 6 (ATF6) is a sensor of the endoplasmic reticulum stress response and regulates expression of several key lipogenic genes.
Pajukanta, P., Hofker, M.H., Glembotski, C.C., Laakso, K., Meex, S.J., Weissglas-Volkov, D., Kallen, C.J., Thuerauf, D.J., Sinsheimer, J.S., Vlietinck, R., Kuusisto, J., Schalkwijk, C.G., Ayoubi, T.A., Wouters, B.G., Taskinen, M.R., Feskens, E.J.M., Greevenbroek, M.M., Bruin, T.W., Stehouwer, C.D., Heldens, J.   +19 more
core   +1 more source

Identification and validation of transcription factors that regulate chromatin dynamics [PDF]

, 2012
Gene expression has to be tightly regulated during all cellular processes. During embryonic development differentiating cells loose their developmental potential and acquire specific functions by activating lineage-specific genes.
Schöler, Anne
core   +1 more source

Protective Effects of Taraxasterol against Deoxynivalenol-Induced Damage to Bovine Mammary Epithelial Cells

Toxins, 2022
Deoxynivalenol (DON), a mycotoxin produced by Fusarium graminearum, is one of the most prevalent contaminants in livestock feed and causes very large losses to animal husbandry every year.
Junxiong Wang, Kexin Zheng, Yongcheng Jin, Yurong Fu, Rui Wang, Jing Zhang   +5 more
doaj   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source