Results 71 to 80 of about 470,318 (298)

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Lipopolysaccharide, high glucose and saturated fatty acids induce endoplasmic reticulum stress in cultured primary human adipocytes : salicylate alleviates this stress [PDF]

, 2010
Recent findings indicate that endoplasmic reticulum (ER) stress is significantly increased in adipose tissue of obese human subjects and is critical to the initiation and integration of pathways of inflammation and insulin action.
Saif Alhusaini, Harte, A., McGee, K., Gyanendra Tripathi, Kumar, Sudhesh, Tripathi, Gyanendra, Sudhesh Kumar, Alhusaini, S., McTernan, P. G., Harte, A. L., McTernan, P., Bruno Schisano, Philip McTernan, Schisano, B., McGee, K. C., Kumar, S., Alison Harte, Tripathi, G., Kirsty McGee   +18 more
core   +1 more source

Transcriptional and epigenetic regulation of follicular T-helper cells and their role in autoimmunity

Autoimmunity, 2017
T-follicular helper (Tfh) cells are a specialized subset of T cells that provide help to B cells and promote the formation of germinal centers (GCs). Tfh cells transmit important signals to B cells that drive class switch recombination, somatic hyper ...
Hong Qiu, Haijing Wu, Vera Chan, Chak-Sing Lau, Qianjin Lu   +4 more
doaj   +1 more source

Transcriptional Activation of the Human Inducible Nitric-oxide Synthase Promoter by Krüppel-like Factor 6 [PDF]

Journal of Biological Chemistry, 2003
L'oxyde nitrique est un radical libre omniprésent qui joue un rôle clé dans un large spectre de voies de signalisation dans les processus physiologiques et physiopathologiques. Nous avons exploré la régulation transcriptionnelle de l'oxyde nitrique synthase inductible (iNOS) par le facteur 6 de type Krüppel (KLF6), un facteur de transcription à doigt ...
Vishal G. Warke, Madhusoodana P. Nambiar, Sandeep Krishnan, Klaus Tenbrock, David A. Geller, Nicolás P. Koritschoner, James L. Atkins, Donna L. Farber, George C. Tsokos   +8 more
openaire   +2 more sources

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

KLF7 induced ADRB3-dependent IL-6 production in brown adipocytes during stress

Journal of Lipid Research
In recent studies, acute physiological stress has been shown to enhance liver gluconeogenesis by activating β3-adrenergic receptor (ADRB3)-dependent interleukin-6 (IL-6) production in brown adipocytes, effectively fueling “fight or flight” responses ...
Maodi Liang, Meixiu Zhang, Yanting Hou, Fangyuan Yuan, Huizi Zhang, Mengyuan Zhao, Lili Xu, Qin Liu, Yurui Su, Xiaolong Chu, Wei Li, Jingzhou Wang, Jianxin Xie, Cuizhe Wang, Qinghua Cui, Jun Zhang   +15 more
doaj   +1 more source

Endoplasmic reticulum stress and liver diseases

Liver Research, 2019
Endoplasmic reticulum (ER) stress occurs when ER homeostasis is perturbed with accumulation of unfolded/misfolded protein or calcium depletion. The unfolded protein response (UPR), comprising of inositol-requiring enzyme 1α (IRE1α), double-stranded RNA ...
Xiaoying Liu, Richard M. Green
doaj   +1 more source

miRNA-1283 Regulates the PERK/ATF4 Pathway in Vascular Injury by Targeting ATF4. [PDF]

PLoS ONE, 2016
In our previous study, we found significant differences in the mRNA and microRNA (miRNA) levels among hypertensive patients with different degrees of vascular endothelial cells damage.
Ling He, Jing Yuan, Qingyun Xu, Ruixue Chen, Liguo Chen, Meixia Fang   +5 more
doaj   +1 more source

Interleukin-4, Interleukin-13, Signal Transducer and Activator of Transcription Factor 6, and Allergic Asthma [PDF]

Current Molecular Medicine, 2008
Interleukin (IL)-4 and IL-13 share many biological activities. To some extent, this is because they both signal via a shared receptor, IL-4Ralpha. Ligation of IL-4Ralpha results in activation of Signal Transducer and Activator of Transcription factor 6 (STAT6) and Insulin Receptor Substrate (IRS) molecules.
Douglas A, Kuperman, Robert P, Schleimer
openaire   +2 more sources

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source