Results 81 to 90 of about 692,400 (286)

Activating transcription factor 6-dependent sestrin 2 induction ameliorates ER stress-mediated liver injury

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2017
Endoplasmic reticulum (ER) stress is characterized by an accumulation of misfolded proteins, and ER stress reduction is essential for maintaining tissue homeostasis. However, the molecular mechanisms that protect cells from ER stress are not completely understood.
Kyung Hwan, Jegal, Sang Mi, Park, Sam Seok, Cho, Sung Hui, Byun, Sae Kwang, Ku, Sang Chan, Kim, Sung Hwan, Ki, Il Je, Cho   +7 more
openaire   +2 more sources

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Transcriptional and epigenetic regulation of follicular T-helper cells and their role in autoimmunity

Autoimmunity, 2017
T-follicular helper (Tfh) cells are a specialized subset of T cells that provide help to B cells and promote the formation of germinal centers (GCs). Tfh cells transmit important signals to B cells that drive class switch recombination, somatic hyper ...
Hong Qiu, Haijing Wu, Vera Chan, Chak-Sing Lau, Qianjin Lu   +4 more
doaj   +1 more source

Transcriptional Activation of the Human Inducible Nitric-oxide Synthase Promoter by Krüppel-like Factor 6 [PDF]

Journal of Biological Chemistry, 2003
L'oxyde nitrique est un radical libre omniprésent qui joue un rôle clé dans un large spectre de voies de signalisation dans les processus physiologiques et physiopathologiques. Nous avons exploré la régulation transcriptionnelle de l'oxyde nitrique synthase inductible (iNOS) par le facteur 6 de type Krüppel (KLF6), un facteur de transcription à doigt ...
Vishal G. Warke, Madhusoodana P. Nambiar, Sandeep Krishnan, Klaus Tenbrock, David A. Geller, Nicolás P. Koritschoner, James L. Atkins, Donna L. Farber, George C. Tsokos   +8 more
openaire   +2 more sources

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Endoplasmic reticulum stress and liver diseases

Liver Research, 2019
Endoplasmic reticulum (ER) stress occurs when ER homeostasis is perturbed with accumulation of unfolded/misfolded protein or calcium depletion. The unfolded protein response (UPR), comprising of inositol-requiring enzyme 1α (IRE1α), double-stranded RNA ...
Xiaoying Liu, Richard M. Green
doaj   +1 more source

miRNA-1283 Regulates the PERK/ATF4 Pathway in Vascular Injury by Targeting ATF4. [PDF]

PLoS ONE, 2016
In our previous study, we found significant differences in the mRNA and microRNA (miRNA) levels among hypertensive patients with different degrees of vascular endothelial cells damage.
Ling He, Jing Yuan, Qingyun Xu, Ruixue Chen, Liguo Chen, Meixia Fang   +5 more
doaj   +1 more source

Molecular mechanisms in haematological malignancies [PDF]

, 2009
Haematopoiesis requires the constant production of large numbers of peripheral blood cells. This process is under tight control of transcription factor networks as well as cytokines, growth factors and hormones.
Avellino, Roberto, Grech, Godfrey, Schembri-Wismayer, Pierre   +2 more
core  

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Expression patterns of serum miR‐27a‐3p and activating transcription factor 3 in children with bronchial asthma and their correlations with airway inflammation

The Clinical Respiratory Journal
Introduction Bronchial asthma (BA) is a heterogeneous disease characterized by chronic airway inflammation. This study investigated the serum miR‐27a‐3p/activating transcription factor 3 (ATF3) expression in children with BA and their correlations with ...
Jingcai Wang, Lixin Yang, Peng Sun, Chunyan Guo, Yuzi Jin, Xiaoqing Jing   +5 more
doaj   +1 more source