Results 101 to 110 of about 470,318 (298)

CONSERVED FUNCTIONAL DOMAINS OF THE RNA-POLYMERASE-III GENERAL TRANSCRIPTION FACTOR BRF

, 1994
In Saccharomyces cerevisiae, two components of the RNA polymerase III (Pol III) general transcription factor TFIIIB are the TATA-binding protein (TBP) and the B-related factor (BRF), so called because its amino-terminal half is homologous to the Pol II ...
JACKSON, SP, BROPHY, B, KHOO, B
core  

Expanding the landscape of the unfolded protein response: The roles of secondary transcription factors in development and disease

Cell Stress & Chaperones
The unfolded protein response (UPR) of the endoplasmic reticulum (ER) is a classic cellular reaction to stress that helps restore ER homeostasis. However, growing evidence demonstrates that the main UPR effectors (Activating Transcription Factor 6 (ATF6),
Miguel Angel Jiménez-Beltrán, Rocío Valle-Bautista, Edgar Ricardo Vázquez-Martínez   +2 more
doaj   +1 more source

Unfolded Protein Response Pathways Correlatively Modulate Endoplasmic Reticulum Stress Responses in Rat Retinal Müller Cells

Journal of Ophthalmology, 2019
Background. Endoplasmic reticulum stress (ERS) in the retinal Müller cells is a key factor contributing to the retinal inflammation and vascular leakage in diabetic retinopathy (DR).
Shengyu Wu, Xiaolu Zhu, Biechuan Guo, Tian Zheng, Jiangbo Ren, Wen Zeng, Xiaomin Chen, Min Ke   +7 more
doaj   +1 more source

Reaction to Endoplasmic Reticulum Stress via ATF6 in Amyotrophic Lateral Sclerosis Deteriorates With Aging

Frontiers in Aging Neuroscience, 2019
Amyotrophic lateral sclerosis (ALS) is a multisystemic neurodegenerative disorder. Given that peripheral blood mononuclear cells (PBMCs) serve as a “window to the central nervous system” we aimed to answer whether endoplasmic reticulum (ER) stress in ALS-
Tino Prell, Tino Prell, Beatrice Stubendorff, Thanh Tu Le, Nayana Gaur, Vedrana Tadić, Annekathrin Rödiger, Otto W. Witte, Otto W. Witte, Julian Grosskreutz, Julian Grosskreutz   +10 more
doaj   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, Volume 20, Issue 6, Page 1591-1611, June 2026.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Sumoylation activates Pax‐6, an important transcription factor for eye and brain development

The FASEB Journal, 2010
Pax‐6 is a master gene controlling eye and brain development. Four isoforms of Pax‐6, p46, p48, p43 and p32/33, have been detected in the vertebrate eye. Absence of the paired domain in the 32kDa Pax‐6 distinguishes it from the other three forms.
Lili Gong, Qin Yan, David W Li
openaire   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Bunyamwera bunyavirus nonstructural protein NSs counteracts the induction of alpha/beta interferon

, 2002
Production of alpha/beta interferons (IFN-α/β) in response to viral infection is one of the main defense mechanisms of the innate immune system. Many viruses therefore encode factors that subvert the IFN system to enhance their virulence.
Richard E. Randall, Randall, Richard E, Friedemann Weber, Fazakerley, John K., Nina Kessler, Weber, F, Elliott, Richard M., Fazakerley, John K, Weber, Friedemann, Weber, F., Streitenfeld, Hein, Elliott, Richard M, Randall, R.E., Kessler, N, Elliott, R.M., Streitenfeld, H., Richard M. Elliott, Kessler, N., Anne Bridgen, Bridgen, A., Streitenfeld, H, Fazakerley, J.K., Kessler, Nina, Hein Streitenfeld, Bridgen, A, Elliott, Richard Michael, Fazakerley, JK, John K. Fazakerley, Bridgen, Anne, Randall, Richard Edward   +29 more
core   +1 more source

Characterization of a Novel Human-Specific STING Agonist that Elicits Antiviral Activity Against Emerging Alphaviruses.

PLoS Pathogens, 2015
Pharmacologic stimulation of innate immune processes represents an attractive strategy to achieve multiple therapeutic outcomes including inhibition of virus replication, boosting antitumor immunity, and enhancing vaccine immunogenicity. In light of this
Tina M Sali, Kara M Pryke, Jinu Abraham, Andrew Liu, Iris Archer, Rebecca Broeckel, Julia A Staverosky, Jessica L Smith, Ahmed Al-Shammari, Lisi Amsler, Kayla Sheridan, Aaron Nilsen, Daniel N Streblow, Victor R DeFilippis   +13 more
doaj   +1 more source

Molecular mechanism of ATF6 regulating the reproduction related gene HSPA1L [PDF]

Jichu yixue yu linchuang
Objective To explore the effect of endoplasmic reticulum stress activating transcription factor 6 (ATF6) on the expression of reproduction related gene heat shock protein family A member 1 like (HSPA1L) and preliminarily clarify its regulatory molecular ...
WANG Yuanyuan, ZHU Xilin, WU Xiaopan, LIU Ying
doaj   +1 more source