Results 21 to 30 of about 688,079 (278)

The transcription factor ATF5: role in cellular differentiation, stress responses, and cancer. [PDF]

, 2017
Activating transcription factor 5 (ATF5) is a cellular prosurvival transcription factor within the basic leucine zipper (bZip) family that is involved in cellular differentiation and promotes cellular adaptation to stress.
Angelastro, James M, Sears, Thomas K
core   +2 more sources

Effect of leucine on endoplasmic reticulum stress induced by early weaning in the liver of piglets

浙江大学学报. 农业与生命科学版, 2018
To investigate the effects of dietary leucine supplementation on endoplasmic reticulum (ER) stress in the liver of early-weaning piglets, we explored the morphology of liver cells, expression pattern of ER stress-associated proteins, and effects on ER ...
FAN Qiwen, CHEN Lingli, ZHAO Li, SHI Min, YAN Xianghua   +4 more
doaj   +1 more source

The Effect of Resistance Training and Berberine Chloride on the Apoptosis-related Unfolded Protein Response Signaling Pathway in the Hippocampus of Diazinon-poisoned Rats

Basic and Clinical Neuroscience, 2021
Introduction: Diazinon is one of the most widely-used organophosphate pesticides in the world. This toxin enters the body in various ways and induces oxidative stress in various tissues.
Ali Esfandiarifar, Mohammad Ali Azarbayjani, Maghsood Peeri, Seyed Behnamedin Jameie   +3 more
doaj  

POST1/C12ORF49 regulates the SREBP pathway by promoting site-1 protease maturation

Protein & Cell, 2020
Sterol-regulatory element binding proteins (SREBPs) are the key transcriptional regulators of lipid metabolism. The activation of SREBP requires translocation of the SREBP precursor from the endoplasmic reticulum to the Golgi, where it is sequentially ...
Jian Xiao, Yanni Xiong, Liu-Ting Yang, Ju-Qiong Wang, Zi-Mu Zhou, Le-Wei Dong, Xiong-Jie Shi, Xiaolu Zhao, Jie Luo, Bao-Liang Song   +9 more
doaj   +1 more source

A pilot study on gene expression of endoplasmic reticulum unfolded protein response in chronic kidney disease

Biochemistry and Biophysics Reports, 2020
Background: Chronic kidney disease (CKD) is a worldwide public health problem due to its increasing prevalence worldwide. Endoplasmic reticulum (ER) stress has been shown to play a role in the pathogenesis of various renal diseases in humans. It leads to
Rasha G. Mostafa, Abd El-Aleem Hassan Abd El-Aleem, Eman Abdella Mahmoud Fouda, Fardous Rabea Ahmed Taha, Khaled Mohamed Amin Elzorkany   +4 more
doaj   +1 more source

The molecular basis of T cell acute lymphoblastic leukemia [PDF]

, 2012
T cell acute lymphoblastic leukemias (T-ALLs) arise from the malignant transformation of hematopoietic progenitors primed toward T cell development, as result of a multistep oncogenic process involving constitutive activation of NOTCH signaling and ...
Adolfo Ferrando, Bash, Bash, Chen, Condorelli, Dube, Fisch, Hagemeijer, Hebert, Ho, Kelliher, Kikuchi, Larson, Lu, McGuire, McGuire, Nagel, Ntziachristos, Ntziachristos, Ono, Pieter Van Vlierberghe, Royer-Pokora, Rubnitz, van Grotel   +23 more
core   +1 more source

Gcn4p and novel upstream activating sequences regulate targets of the unfolded protein response. [PDF]

, 2004
Eukaryotic cells respond to accumulation of unfolded proteins in the endoplasmic reticulum (ER) by activating the unfolded protein response (UPR), a signal transduction pathway that communicates between the ER and the nucleus.
Li, Hao, Patil, Christopher K, Walter, Peter   +2 more
core   +4 more sources

Expression of markers of endoplasmic reticulum stress-induced apoptosis in the placenta of women with early and late onset severe pre-eclampsia

Taiwanese Journal of Obstetrics & Gynecology, 2015
Objectives: Endoplasmic reticulum (ER) stress-induced apoptosis has been implicated in severe pre-eclampsia (SPE) and is characterized by the activation of three signaling pathways: PKR-like endoplasmic reticulum kinase (PERK), activating transcription ...
Jinhua Fu, Long Zhao, Li Wang, Xiaohe Zhu   +3 more
doaj   +1 more source

Rifampicin protects PC12 cells from rotenone-induced cytotoxicity by activating GRP78 via PERK-eIF2α-ATF4 pathway. [PDF]

PLoS ONE, 2014
Rifampicin has been proposed as a therapeutic candidate for Parkinson's disease (PD). We previously showed that rifampicin was neuroprotective in PD models in vivo and in vitro. However, the molecular mechanisms underlying are not fully elucidated.
Xiuna Jing, Qiaoyun Shi, Wei Bi, Zhifen Zeng, Yanran Liang, Xia Wu, Songhua Xiao, Jun Liu, Lianhong Yang, Enxiang Tao   +9 more
doaj   +1 more source

Metabolic syndrome influences cardiac gene expression pattern at the transcript level in male ZDF rats [PDF]

, 2013
Background: Metabolic syndrome (coexisting visceral obesity, dyslipidemia, hyperglycemia, and hypertension) is a prominent risk factor for cardiovascular morbidity and mortality, however, its effect on cardiac gene expression pattern is unclear ...
Csonka, Csaba, Csont, Tamás Bálint, Fekete, Veronika, Ferdinandy, Péter, Gyémánt, Nóra, Kocsis-Fodor, Gabriella, Pipis, Judit, Puskás, László, Szűcs, Gergő, Sárközy, Márta, Zvara, Ágnes   +10 more
core   +3 more sources