Krüppel-like factor 6 is a transcriptional activator of autophagy in acute liver injury [PDF]
Scientific Reports, 2017 AbstractKrüppel-like factor 6 (KLF6) is a transcription factor and tumor suppressor. We previously identified KLF6 as mediator of hepatocyte glucose and lipid homeostasis. The loss or reduction of KLF6 is linked to the progression of hepatocellular carcinoma, but its contribution to liver regeneration and repair in acute liver injury are lacking so far.
Francisco Javier Cubero +24 more
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The Forkhead Transcription Factor AFX Activates Apoptosis by Induction of the BCL-6 Transcriptional Repressor [PDF]
Journal of Biological Chemistry, 2002 The activation of the AKT/protein kinase B kinases by mutation of the PTEN lipid phosphatase results in enhanced survival of a diversity of tumors. This resistance to apoptosis is partly accomplished by the inhibition of genetic programs induced by a subfamily of forkhead transcription factors including AFX.
Tracy Tang +6 more
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Sirtuin 6 promotes eosinophil differentiation by activating GATA‐1 transcription factor
Aging Cell, 2021 AbstractThere is evidence emerging that exposure to cold temperatures enhances alternative activation of macrophages in white adipose tissue (WAT), which promotes adipocyte beiging and adaptive thermogenesis. Although we recently reported that NAD+‐dependent deacetylase sirtuin 6 (Sirt6) drives alternatively activated (M2) macrophage polarization, the ...
In Hyuk Bang +5 more
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Interleukin-6 activates and regulates transcription factors of the interferon regulatory factor family in M1 cells. [PDF]
Journal of Biological Chemistry, 1993 Activation of (2'-5') A synthetase gene expression in interleukin-6 (IL-6)-treated myeloleukemic M1 cells correlates with protein binding to the interferon response sequence enhancer (IRS). A new interferon response sequence complex, F6, is induced by IL-6 independently of interferon and is identified here as comprising the interferon regulatory factor-
Sheila Harroch +4 more
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Heat Shock Transcription Factor 1 Inhibits Expression of IL-6 through Activating Transcription Factor 3 [PDF]
The Journal of Immunology, 2009 Abstract The febrile response is a complex physiological reaction to disease, including a cytokine-mediated increase in body temperature and the activation of inflammatory systems. Fever has beneficial roles in terms of disease prognosis, partly by suppressing the expression of inflammatory cytokines.
Ryosuke Takii +10 more
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Frontiers in Oncology, 2020 The treatment of melanoma has remained a difficult challenge. Targeting the tumor stroma has recently attracted attention for developing novel strategies for melanoma therapy.
Tingjian Zu +15 more
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The participation of activating transcription factor 6 alpha, ATF6α, in Alzheimer’s disease [PDF]
Alzheimers DementAbstractBackgroundAlzheimer’s disease (AD) is the leading cause of dementia in elderly humans worldwide. More than 40 million people currently suffer from AD, and this prevalence tends to increase considerably in the coming decades due to increased longevity.
Chauvet M, Isaac A, Lourenco M.
europepmc +2 more sources
陆军军医大学学报, 2023 Objective To investigate the effects of activating transcription factor 6 (ATF6) on the proliferation, migration and invasion of prostate cancer PC3 cells.
LIU Hengchuan +5 more
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Regression/eradication of gliomas in mice by a systemically-deliverable ATF5 dominant-negative peptide. [PDF]
, 2016 Malignant gliomas have poor prognosis and urgently require new therapies. Activating Transcription Factor 5 (ATF5) is highly expressed in gliomas, and interference with its expression/function precipitates targeted glioma cell apoptosis in vitro and in ...
Angelastro, James +11 more
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21 IL-6 Dependent Activation of T Cell in Colitis By Transcription Factor NFATC2
Gastroenterology, 2008 Benno Weigmann +4 more
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