The eukaryotic initiation factor 2 kinase GCN2 protects against hepatotoxicity during asparaginase treatment [PDF]
, 2013 Asparaginase is an important drug in the treatment regimen for acute lymphoblastic leukemia. Asparaginase depletes circulating asparagine and glutamine, activating an amino acid stress response (AAR) involving phosphorylation of eukaryotic initiation ...
Anthony, Tracy G. +4 more
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Effect of leucine on endoplasmic reticulum stress induced by early weaning in the liver of piglets
浙江大学学报. 农业与生命科学版, 2018 To investigate the effects of dietary leucine supplementation on endoplasmic reticulum (ER) stress in the liver of early-weaning piglets, we explored the morphology of liver cells, expression pattern of ER stress-associated proteins, and effects on ER ...
FAN Qiwen +4 more
doaj +1 more source
POST1/C12ORF49 regulates the SREBP pathway by promoting site-1 protease maturation
Protein & Cell, 2020 Sterol-regulatory element binding proteins (SREBPs) are the key transcriptional regulators of lipid metabolism. The activation of SREBP requires translocation of the SREBP precursor from the endoplasmic reticulum to the Golgi, where it is sequentially ...
Jian Xiao +9 more
doaj +1 more source
Platelet-derived Growth Factor Induces Interleukin-6 Transcription in Osteoblasts through the Activator Protein-1 Complex and Activating Transcription Factor-2 [PDF]
Journal of Biological Chemistry, 1999 Platelet-derived growth factor (PDGF) BB, a mitogen that stimulates bone resorption, increases the expression of interleukin-6 (IL-6), a cytokine that induces osteoclast recruitment. The mechanisms involved in IL-6 induction by PDGF BB are poorly understood.
Sheila Rydziel +4 more
openaire +2 more sources
Basic and Clinical Neuroscience, 2021 Introduction: Diazinon is one of the most widely-used organophosphate pesticides in the world. This toxin enters the body in various ways and induces oxidative stress in various tissues.
Ali Esfandiarifar +3 more
doaj
Rifampicin protects PC12 cells from rotenone-induced cytotoxicity by activating GRP78 via PERK-eIF2α-ATF4 pathway. [PDF]
PLoS ONE, 2014 Rifampicin has been proposed as a therapeutic candidate for Parkinson's disease (PD). We previously showed that rifampicin was neuroprotective in PD models in vivo and in vitro. However, the molecular mechanisms underlying are not fully elucidated.
Xiuna Jing +9 more
doaj +1 more source
The transcription factor ATF5: role in cellular differentiation, stress responses, and cancer. [PDF]
, 2017 Activating transcription factor 5 (ATF5) is a cellular prosurvival transcription factor within the basic leucine zipper (bZip) family that is involved in cellular differentiation and promotes cellular adaptation to stress.
Angelastro, James M, Sears, Thomas K
core +2 more sources
A model for how signal duration can determine distinct outcomes of gene transcription programs. [PDF]
PLoS ONE, 2012 The reason why IL-6 induces a pro-inflammatory response, while IL-10 induces an anti-inflammatory response, despite both cytokines activating the same transcription factor, STAT3, is not well understood.
Kevin D Fowler +2 more
doaj +1 more source
The Synergistic Regulatory Effect of Runx2 and MEF Transcription Factors on Osteoblast Differentiation Markers [PDF]
, 2010 Purpose: Bone tissues for clinical application can be improved by studies on osteoblast differentiation. Runx2 is known to be an important transcription factor for osteoblast differentiation.
Cho, Je-Yoel +2 more
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Taiwanese Journal of Obstetrics & Gynecology, 2015 Objectives: Endoplasmic reticulum (ER) stress-induced apoptosis has been implicated in severe pre-eclampsia (SPE) and is characterized by the activation of three signaling pathways: PKR-like endoplasmic reticulum kinase (PERK), activating transcription ...
Jinhua Fu +3 more
doaj +1 more source