The transcription factor NFATc2 controls IL-6–dependent T cell activation in experimental colitis [PDF]
The Journal of Experimental Medicine, 2008 The nuclear factor of activated T cells (NFAT) family of transcription factors controls calcium signaling in T lymphocytes. In this study, we have identified a crucial regulatory role of the transcription factor NFATc2 in T cell–dependent experimental colitis.
Weigmann, B. +9 more
openaire +4 more sources
Hepatitis C Virus NS3 Mediated Microglial Inflammation via TLR2/TLR6 MyD88/NF-κB Pathway and Toll Like Receptor Ligand Treatment Furnished Immune Tolerance. [PDF]
PLoS ONE, 2015 Recent evidence suggests the neurotrophic potential of hepatitis C virus (HCV). HCV NS3 protein is one of the potent antigens of this virus mediating inflammatory response in different cell types.
Ayilam Ramachandran Rajalakshmy +2 more
doaj +1 more source
Biomedicines, 2021 Autophagy in the proximal tubules may promote fibrosis by activating tubular cell death, interstitial inflammation, and the production of pro-fibrotic factors.
Young-Ah Kim +8 more
doaj +1 more source
European Journal of Medical Research, 2023 Activating transcription factor 6 (ATF6) is an endoplasmic reticulum stress responsive gene. We previously reported that conditional knockout of hepatic ATF6 exacerbated liver metabolic damage by repressing autophagy through mTOR pathway.
Bingzi Dong +5 more
doaj +1 more source
Endoplasmic Reticulum Stress Induced Proliferation Remains Intact in Aging Mouse β-Cells
Frontiers in Endocrinology, 2021 Aging is associated with loss of proliferation of the insulin-secreting β-cell, a possible contributing factor to the increased prevalence of type 2 diabetes in the elderly.
Jarin T. Snyder +3 more
doaj +1 more source
Toxins, 2022 Deoxynivalenol (DON), a mycotoxin produced by Fusarium graminearum, is one of the most prevalent contaminants in livestock feed and causes very large losses to animal husbandry every year.
Junxiong Wang +5 more
doaj +1 more source
miR-199a-5p silencing regulates the unfolded protein response in chronic obstructive pulmonary disease and α1-antitrypsin deficiency. [PDF]
, 2014 RATIONALE: Retention of abnormal α1-antitrypsin (AAT) activates the unfolded protein response in AAT-deficient monocytes. The regulatory role of microRNAs (miRNAs) in unfolded protein responses and chronic obstructive pulmonary disease pathogenesis has ...
Buckley, Patrick G +6 more
core +1 more source
Gene Expression Profile Changes After Short-activating RNA-mediated Induction of Endogenous Pluripotency Factors in Human Mesenchymal Stem Cells [PDF]
, 2012 It is now recognized that small noncoding RNA sequences have the ability to mediate transcriptional activation of specific target genes in human cells.
Alluin, J +7 more
core +4 more sources
Activating Transcription Factor 4 Links Metabolic Stress to Interleukin-6 Expression in Macrophages [PDF]
Diabetes, 2013 Chronic inflammation is a molecular element of the metabolic syndrome and type 2 diabetes. Saturated fatty acids (SFAs) are considered to be an important proinflammatory factor. However, it is still incompletely understood how SFAs induce proinflammatory cytokine expression. Hereby we report that activating transcription factor (ATF) 4, a transcription
Miho Hamaguchi +11 more
openaire +3 more sources
International Journal of Plant Based Pharmaceuticals, 2022 Cancer is one of the diseases that became a social problem that can happen with uncontrolled proliferation, growth, differentiation, and spread of cells in our body.
Ibrahim Hakkı Cigerci +3 more
doaj +1 more source