Activation induced cytidine deaminase: An old friend with new faces [PDF]
Frontiers in Immunology, 2022 Activation induced cytidine deaminase (AID) protein is a member of APOBEC family. AID converts cytidine to uracil, which is a key step for somatic hypermutation (SHM) and class switch recombination (CSR). AID also plays critical roles in B cell precursor
Elif Çakan, Gurcan Gunaydin
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Lack of activation-induced cytidine deaminase expression in in situ follicular neoplasia [PDF]
Haematologica, 2020 Tanu Goyal +4 more
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Optimized high‐fidelity 3DPCR to assess potential mitochondrial targeting by activation‐induced cytidine deaminase [PDF]
FEBS Open Bio, 2020 Activation‐induced cytidine deaminase (AID) initiates somatic hypermutation and class switch recombination of immunoglobulin genes in B cells, whereas off‐targeted AID activity contributes to oncogenic mutations and chromosomal translocations associated ...
Haiyan Wu +5 more
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Deficiency of activation-induced cytidine deaminase in a murine model of ulcerative colitis. [PDF]
PLoS ONE, 2020 Patients with inflammatory bowel disease (IBD) have an increased risk of colorectal cancer, particularly in ulcerative colitis (UC) when the majority of colon epithelial cells may be exposed to inflammation-associated mutagenesis.
Laura P Hale
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Activation-Induced Cytidine Deaminase Links Ovulation-Induced Inflammation and Serous Carcinogenesis [PDF]
Neoplasia: An International Journal for Oncology Research, 2016 In recent years, the notion that ovarian carcinoma results from ovulation-induced inflammation of the fallopian tube epithelial cells (FTECs) has gained evidence. However, the mechanistic pathway for this process has not been revealed yet. In the current
Stav Sapoznik +19 more
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Two forms of activation-induced cytidine deaminase differing in their ability to bind agarose. [PDF]
PLoS ONE, 2010 Activation-induced cytidine deaminase (AID) is a B-cell-specific DNA mutator that plays a key role in the formation of the secondary antibody repertoire in germinal center B cells.
Mirjam Metzner +4 more
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Epigenetic function of Activation-Induced Cytidine Deaminase (AID) and its link to lymphomagenesis [PDF]
Frontiers in Immunology, 2014 Activation-induced cytidine deaminase (AID) is essential for somatic hypermutation (SHM) and class switch recombination (CSR) of immunoglobulin (Ig) genes during B cell maturation and immune response.
Pilar M Dominguez +2 more
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A Protein Antagonist of Activation-Induced Cytidine Deaminase Encoded by a Complex Mouse Retrovirus [PDF]
mBio, 2019 Complex human-pathogenic retroviruses cause high morbidity and mortality worldwide, but resist antiviral drugs and vaccine development due to evasion of the immune response.
Gurvani B. Singh +8 more
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Activation-induced cytidine deaminase in tertiary lymphoid structures: dual roles and implications in cancer prognosis [PDF]
Frontiers in OncologyActivation-induced cytidine deaminase (AID) serves as a critical molecular orchestrator in the germinal center (GC) reaction within secondary lymphoid organs (SLOs), driving the production of high-affinity antibodies through somatic hypermutation.
Zhuangwei Lv +6 more
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Activation-induced cytidine deaminase causes recurrent splicing mutations in diffuse large B-cell lymphoma [PDF]
Molecular CancerDiffuse large B-cell lymphoma (DLBCL) is the most common lymphoma. A major mutagenic process in DLBCL is aberrant somatic hypermutation (aSHM) by activation-induced cytidine deaminase (AID), which occurs preferentially at RCH/TW sequence motifs proximal ...
Maria S. Benitez-Cantos +3 more
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