Results 91 to 100 of about 11,119 (186)

Activation‐induced cytidine deaminase auto‐activates and triggers aberrant gene expression

FEBS Letters, 2013
DNA methylation is a well‐characterized epigenetic landmark involved in transcriptional regulation; however, mechanisms underlying its regulation remain poorly characterized. Recent studies demonstrate that activation‐induced cytidine deaminase (AID) is involved in active DNA demethylation. AID is aberrantly expressed in inflammation‐associated cancers
Tomoyasu Isobe, Soken-Nakazawa J. Song, Prabha Tiwari, Hiroki Ito, Yuki Yamaguchi, Kazuyuki Yoshizaki   +5 more
openaire   +2 more sources

Circulating Follicular Helper and Follicular Regulatory T Cells Are Severely Compromised in Human CD40 Deficiency: A Case Report

Frontiers in Immunology, 2018
Mutations in genes that control class switch recombination and somatic hypermutation during the germinal center (GC) response can cause diverse immune dysfunctions.
Maria Pia Cicalese, Maria Pia Cicalese, Maria Pia Cicalese, Jolanda Gerosa, Manuela Baronio, Davide Montin, Francesco Licciardi, Annarosa Soresina, Rosa Maria Dellepiane, Maurizio Miano, Lucia Augusta Baselli, Stefano Volpi, Carlo Dufour, Carlo Dufour, Alessandro Plebani, Alessandro Aiuti, Alessandro Aiuti, Alessandro Aiuti, Vassilios Lougaris, Georgia Fousteri   +19 more
doaj   +1 more source

Data from Target Sequence Accessibility Limits Activation-Induced Cytidine Deaminase Activity in Primary Mediastinal B-Cell Lymphoma

, 2023
Sergey Popov, Gerhard Moldenhauer, Beate Wotschke, Silke Brüderlein, Thomas F.E. Barth, Karola Dorsch, Olga Ritz, Peter Mӧller, Frank Leithäuser   +8 more
openalex   +1 more source

Antibody Affinity Maturation in Fishes—Our Current Understanding

Biology, 2015
It has long been believed that fish lack antibody affinity maturation, in part because they were thought to lack germinal centers. Recent research done on sharks and bony fishes indicates that these early vertebrates are able to affinity mature their ...
Brad G. Magor
doaj   +1 more source

Domain organization of activation-induced cytidine deaminase [PDF]

Nature Immunology, 2003
Zaim, J, Kierzek, AM
openaire   +3 more sources

Activation-induced cytidine deaminase an antibody diversification enzyme interacts with chromatin modifier UBN1 in B-cells. [PDF]

Sci Rep, 2023
Jaiswal A, Roy R, Tamrakar A, Singh AK, Kar P, Kodgire P.   +5 more
europepmc   +1 more source

Supplementary Figures and Tables 1-3 from Activation-Induced Cytidine Deaminase Accelerates Clonal Evolution in <i>BCR-ABL1</i>–Driven B-Cell Lineage Acute Lymphoblastic Leukemia

, 2023
Tanja A. Grüber, Mi Sook Chang, Richard Sposto, Markus Müschen   +3 more
openalex   +2 more sources

Identification of two epitypes of IGHV unmutated chronic lymphocytic leukemia with distinct B‐cell‐related epigenetic imprinting and genetic alterations

HemaSphere, Volume 10, Issue 1, January 2026.
Stella Charalampopoulou, Silvia Ramos‐Campoy, Marti Duran‐Ferrer, Anna Puiggros, Joanna Kamaso, Florence Nguyen‐Khac, Gian Matteo Rigolin, Antonio Cuneo, Rosa Collado, Rocío García‐Serra, Claudia Haferlach, Margarita Ortega, Pau Abrisqueta, Francesc Bosch, Thorsten Zenz, María Laura Blanco, Rocío Salgado, Mª Dolores García‐Malo, Eva Gimeno, Armando Lopez‐Guillermo, Elias Campo, Laurence Etter, Jacqueline Schoumans, Blanca Espinet, Jose I. Martin‐Subero   +24 more
wiley   +1 more source

Editing Streptomyces genome using target AID system fused with UGI‐degradation tag

Engineering in Life Sciences
The utilization of Streptomyces as a microbial chassis for developing innovative drugs and medicinal compounds showcases its capability to produce bioactive natural substances. Recent focus on the clustered regularly interspaced short palindromic repeat (
Pamella Apriliana, Prihardi Kahar, Norimasa Kashiwagi, Akihiko Kondo, Chiaki Ogino   +4 more
doaj   +1 more source

Epstein-Barr virus infection of infants: implications of early age of infection on viral control and risk for Burkitt lymphoma

Boletín Médico del Hospital Infantil de México, 2016
Since its first description by Denis Burkitt, endemic Burkitt's lymphoma (BL), the most common childhood cancer in sub-Saharan Africa, has led scientists to search for clues to the origins of this malignancy.
Rosemary Rochford
doaj   +1 more source