Results 171 to 180 of about 11,119 (186)
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Ictalurus Punctatus Activation-Induced Cytidine Deaminase Expression
2020Antigen-specific recognition and memory, the hallmarks of conventional mammalian adaptive immunity, are found in all jawed vertebrates along with all elements central to cognate adaptive immune responses (e.g. B-cells). During T-cell-dependent humoral immune responses in mammals, antigen-specific recognition is significantly enhanced by antibody ...
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Activation-Induced Cytidine Deaminase Aided In Vitro Antibody Evolution
2018Activation-induced cytidine deaminase (AID) initiates somatic hypermutation (SHM) by converting deoxycytidines (dC) to deoxyuracils (dU) which then can induce other mutations, and plays a central role in introducing diversification of the antibody repertoire in B cells.
Lili, An +4 more
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Activation-induced cytidine deaminase turns on somatic hypermutation in hybridomas
Nature, 2002The production of high-affinity protective antibodies requires somatic hypermutation (SHM) of the antibody variable (V)-region genes. SHM is characterized by a high frequency of point mutations that occur only during the centroblast stage of B-cell differentiation. Activation-induced cytidine deaminase (AID), which is expressed specifically in germinal-
Alberto, Martin +5 more
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Examining the Structure of Activation‐Induced Cytidine Deaminase (AID)
The FASEB Journal, 2020In order to respond to any foreign antigen that might present itself, B cells must produce antibodies of great variety. Activation‐Induced Cytidine Deaminase (AID) is a protein that plays a critical role in the diversification of antibodies.1 Discovered by T. Honjo et al.
Angela Feng, Katherine Alex
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Activation-induced cytidine deaminase mRNA levels in chronic lymphocytic leukemia
Leukemia & Lymphoma, 2010The Rai and Binet staging systems, which are used as standard methods for evaluating the prognosis of chronic lymphocytic leukemia (CLL), have some restrictions in identifying patients with early-stage CLL who will progress rapidly. To solve this defect, other prognostic parameters have become important in recent years.
Veysel Sabri, Hancer +4 more
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Chromosome Translocation, B Cell Lymphoma, and Activation-Induced Cytidine Deaminase
Annual Review of Pathology: Mechanisms of Disease, 2013Studies of B cell lymphomas in the early 1980s led to the cloning of genes (c-MYC and IGH) at a chromosome translocation breakpoint. A rush followed to identify recurrently translocated genes in all types of cancer, which led to remarkable advances in our understanding of cancer genetics.
Davide F, Robbiani +1 more
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Activation-induced cytidine deaminase mutator activity targeting through phosphorylation
The Journal of Immunology, 2018Abstract Activation induced cytidine deaminase (AID) initiates immunoglobulin class switch recombination (CSR) and somatic hypermutation (SHM) by deaminating transcribed double stranded DNA to produce U:G mismatches. Subsequent processing of lesions complete SHM or CSR. AID mutator activity predominantly targets the immunoglobulin locus,
Kevin M McBride +2 more
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Expression of activation-induced cytidine deaminase in Bowenoid papulosis
European Journal of Dermatology, 2013ejd.2013.2125 Auteur(s) : Takashi Yamaguchi, Motonobu Nakamura motonaka@med.uoeh-u.ac.jp Department of Dermatology, University of Occupational and Environmental Health, 1-1 Iseigaoka, Yahatanishi-ku, Kitakyushu 807-8555, Japan Bowenoid papuloses are small papules with a verrucous appearance in the ano-genital region, often associated with infection of ...
Takashi Yamaguchi, Motonobu Nakamura
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Discovery of Activation‐Induced Cytidine Deaminase, the Engraver of Antibody Memory
2007Discovery of activation-induced cytidine deaminase (AID) paved a new path to unite two genetic alterations induced by antigen stimulation; class switch recombination (CSR) and somatic hypermutation (SHM). AID is now established to cleave specific target DNA and to serve as engraver of these genetic alterations.
Masamichi, Muramatsu +4 more
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Characterization of bovine activation-induced cytidine deaminase
Veterinary Immunology and Immunopathology, 2009Subhash Verma, Tom Goldammer, Rob Aitken
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