Results 11 to 20 of about 11,119 (186)

Biological function of activation-induced cytidine deaminase (AID)

Biomedical Journal, 2014
Activation-induced Cytidine Deaminase (AID) is an essential regulator of B cell diversification, but its full range of action has until recently been an enigma. Based on homology, it was originally proposed to be an RNA-editing enzyme, but so far, no RNA
Ritu Kumar, Lauren J DiMenna, Jayanta Chaudhuri, Todd Evans   +3 more
doaj   +3 more sources

Activation-induced cytidine deaminase deficiency causes organ-specific autoimmune disease.

PLoS ONE, 2008
Activation-induced cytidine deaminase (AID) expressed by germinal center B cells is a central regulator of somatic hypermutation (SHM) and class switch recombination (CSR).
Koji Hase, Daisuke Takahashi, Masashi Ebisawa, Sayaka Kawano, Kikuji Itoh, Hiroshi Ohno   +5 more
doaj   +4 more sources

Aberrant Activation-Induced Cytidine Deaminase Gene Expression Links BCR/ABL1-Negative Classical Myeloproliferative Neoplasms

Haseki Tıp Bülteni, 2022
Aim:Activation-induced cytidine deaminase (AID) has been associated with tumor initiation and development because of its ability to generate DNA damage and somatic mutations that cause genomic instability. This study aimed to investigate the relationship
Hasan Dermenci, Aynur Daglar Aday, Aysegul Basak Akadam Teker, Veysel Sabri Hancer, Metin Yusuf Gelmez, Meliha Nalcaci, Akif Selim Yavuz   +6 more
doaj   +2 more sources

Ago2 and a miRNA reduce Topoisomerase 1 for enhancing DNA cleavage in antibody diversification by activation-induced cytidine deaminase. [PDF]

Proc Natl Acad Sci U S A, 2023
Kobayashi M, Wakaguri H, Shimizu M, Higasa K, Matsuda F, Honjo T.   +5 more
europepmc   +3 more sources

Activation-induced cytidine deaminase is a possible regulator of cross-talk between oocytes and granulosa cells through GDF-9 and SCF feedback system. [PDF]

Sci Rep, 2021
Iizuka T, Wakae K, Ono M, Suzuki T, Mizumoto Y, Kitamura K, Horike SI, Muramatsu M, Fujiwara H.   +8 more
europepmc   +3 more sources

Role of activation-induced cytidine deaminase in the development of oral squamous cell carcinoma. [PDF]

PLoS ONE, 2013
PURPOSE: In humans, activation-induced cytidine deaminase (AID) expression results due to inflammation and this deaminase activity is also involved in carcinogenesis.
Yosuke Nakanishi, Satoru Kondo, Naohiro Wakisaka, Akira Tsuji, Kazuhira Endo, Shigeyuki Murono, Makoto Ito, Kouichi Kitamura, Masamichi Muramatsu, Tomokazu Yoshizaki   +9 more
doaj   +2 more sources

Sustained activation induced cytidine deaminase (AID) expression in B cells following Plasmodium falciparum malaria infection in Kenyan children. [PDF]

J Immunol
Ariera B, Guyah B, Rahkola J, Arao I, Waomba K, Koech E, Samayoa-Reyes G, Sabourin KR, Ogolla S, Rochford R.   +9 more
europepmc   +3 more sources

Upregulated Expression of Activation-Induced Cytidine Deaminase in Ocular Adnexal Marginal Zone Lymphoma with IgG4-Positive Cells. [PDF]

Int J Mol Sci, 2021
Nishikori A, Nishimura Y, Shibata R, Ohshima KI, Gion Y, Ikeda T, Nishimura MF, Yoshino T, Sato Y.   +8 more
europepmc   +3 more sources

Post-translational regulation of activation-induced cytidine deaminase [PDF]

Philosophical Transactions of the Royal Society B: Biological Sciences, 2008
The assembled immunoglobulin genes in the B cells of mice and humans are altered by distinct processes known as class switch recombination (CSR) and somatic hypermutation, leading to diversification of the antibody repertoire.
Uttiya Basu, Andrew Franklin, Frederick W. Alt   +2 more
openalex   +3 more sources

Frequent expression of activation-induced cytidine deaminase in diffuse large B-cell lymphoma tissues from persons living with HIV. [PDF]

AIDS, 2020
Shponka V, Reveles CY, Alam S, Jaramillo M, Maguire A, Rimsza LM, Kendrick S.   +6 more
europepmc   +3 more sources