Results 21 to 30 of about 11,119 (186)

Activation-induced cytidine deaminase: in sickness and in health. [PDF]

J Cancer Res Clin Oncol, 2020
Activation Induced cytidine Deaminase (AID) is an essential enzyme of the adaptive immune system. Its canonical activity is restricted to B lymphocytes, playing an essential role in the diversification of antibodies by enhancing specificity and changing affinity. This is possible through its DNA deaminase function, leading to mutations in DNA.
Rios LAS, Cloete B, Mowla S.
europepmc   +3 more sources

Insights on SNPs of Human Activation-Induced Cytidine Deaminase AID. [PDF]

Int J Mol Sci
Koveshnikova EA, Kuznetsova AA.
europepmc   +3 more sources

RNA-binding motifs of hnRNP K are critical for induction of antibody diversification by activation-induced cytidine deaminase. [PDF]

Proc Natl Acad Sci U S A, 2020
Yin Z, Kobayashi M, Hu W, Higashi K, Begum NA, Kurokawa K, Honjo T.   +6 more
europepmc   +3 more sources

Epstein-Barr Virus Lytic Reactivation Activates B Cells Polyclonally and Induces Activation-Induced Cytidine Deaminase Expression: A Mechanism Underlying Autoimmunity and Its Contribution to Graves' Disease. [PDF]

Viral Immunol, 2017
Nagata K, Kumata K, Nakayama Y, Satoh Y, Sugihara H, Hara S, Matsushita M, Kuwamoto S, Kato M, Murakami I, Hayashi K.   +10 more
europepmc   +3 more sources

Epigenetic targeting of activation-induced cytidine deaminase. [PDF]

Proc Natl Acad Sci U S A, 2014
Significance Activation-induced cytidine deaminase (AID) is a DNA modifying enzyme crucial for the generation of efficacious antibodies. AID also promiscuously introduces DNA lesions at cancer genes, leading to their chromosome translocation and lymphoma. However, how AID is recruited to these off targets is not well understood.
Wang Q, Oliveira T, Jankovic M, Silva IT, Hakim O, Yao K, Gazumyan A, Mayer CT, Pavri R, Casellas R, Nussenzweig MC, Robbiani DF.   +11 more
europepmc   +4 more sources

Activation induced cytidine deaminase expression in lymphocyte predominant Hodgkin lymphoma [PDF]

Journal of Clinical Pathology, 2005
Background: The lymphocytic and histiocytic (L&H) cells of lymphocyte predominant Hodgkin lymphoma (HL) originate from germinal centre B cells and carry mutated V gene rearrangements, usually with intraclonal diversity. It is unclear whether intraclonal V gene diversification by somatic hypermutation, which is strictly dependent ...
Anja Mottok, M-L Hansmann, Andreas Bräuninger   +2 more
openalex   +4 more sources

LINE-1 retroelements complexed and inhibited by activation induced cytidine deaminase. [PDF]

PLoS ONE, 2012
LINE-1 (abbreviated L1) is a major class of retroelements in humans and mice. If unrestricted, retroelements accumulate in the cytoplasm and insert their DNA into the host genome, with the potential to cause autoimmune disease and cancer.
Mirjam Metzner, Hans-Martin Jäck, Matthias Wabl   +2 more
doaj   +1 more source

Multiple gene substitution by Target-AID base-editing technology in tomato

Scientific Reports, 2020
The use of Target activation-induced cytidine deaminase (Target-AID) base-editing technology with the CRISPR-Cas 9 system fused with activation-induced cytidine deaminase (AID) resulted in the substitution of a cytidine with a thymine.
Johan Hunziker, Keiji Nishida, Akihiko Kondo, Sanae Kishimoto, Tohru Ariizumi, Hiroshi Ezura   +5 more
doaj   +1 more source

AIDmut-Seq: a Three-Step Method for Detecting Protein-DNA Binding Specificity

Microbiology Spectrum, 2023
Transcriptional factors (TFs) and their regulons make up the gene regulatory networks. Here, we developed a method based on TF-directed activation-induced cytidine deaminase (AID) mutagenesis in combination with genome sequencing, called AIDmut-Seq, to ...
Feixuan Li, Xiao-Yu Liu, Lei Ni, Fan Jin
doaj   +1 more source

Biochemical Regulatory Features of Activation-Induced Cytidine Deaminase Remain Conserved from Lampreys to Humans. [PDF]

Mol Cell Biol, 2017
Quinlan EM, King JJ, Amemiya CT, Hsu E, Larijani M.   +4 more
europepmc   +3 more sources