Results 31 to 40 of about 11,119 (186)

The Double-Edged Sword of Activation-Induced Cytidine Deaminase [PDF]

The Journal of Immunology, 2005
Abstract Activation-induced cytidine deaminase (AID) is required for Ig class switch recombination, a process that introduces DNA double-strand breaks in B cells. We show in this study that AID associates with the DNA-dependent protein kinase catalytic subunit (DNA-PKcs) promoting cell survival, presumably by resolving DNA double-strand ...
Xiaosheng, Wu, Pedro, Geraldes, Jeffrey L, Platt, Marilia, Cascalho   +3 more
openaire   +2 more sources

Regulation of hypermutation by activation-induced cytidine deaminase phosphorylation [PDF]

Proceedings of the National Academy of Sciences, 2006
Activation-induced cytidine deaminase (AID) initiates Ig class switch recombination and somatic hypermutation by producing U:G mismatches in DNA. These mismatches also have the potential to induce DNA damage including double-stranded breaks and chromosome translocations; therefore, strict regulation of AID is important for ...
Kevin M, McBride, Anna, Gazumyan, Eileen M, Woo, Vasco M, Barreto, Davide F, Robbiani, Brian T, Chait, Michel C, Nussenzweig   +6 more
openaire   +2 more sources

AID assists DNMT1 to attenuate BCL6 expression through DNA methylation in diffuse large B-cell lymphoma cell lines

Neoplasia: An International Journal for Oncology Research, 2020
The BCL6 proto-oncogene encodes a transcriptional repressor, which is required for germinal centers (GCs) formation and lymphomagenesis. Previous studies have been reported that the constitutive expression of BCL6 leads to diffuse large B cell lymphoma ...
Junna Jiao, Zhuangwei Lv, Ping Zhang, Yang Wang, Meng Yuan, Xiaozhuo Yu, Woodvine Otieno Odhiambo, Mingzhe Zheng, Hua Zhang, Yunfeng Ma, Yanhong Ji   +10 more
doaj   +1 more source

Introduction of pathogenic mutations into the mouse Psen1 gene by Base Editor and Target-AID

Nature Communications, 2018
CRISPR-guided cytidine deaminases, including BE3 (Base Editor 3) and Target-AID (activation-induced cytidine deaminase), can covert C:G base pairs to T:A at target site.
Hiroki Sasaguri, Kenichi Nagata, Misaki Sekiguchi, Ryo Fujioka, Yukio Matsuba, Shoko Hashimoto, Kaori Sato, Deepika Kurup, Takanori Yokota, Takaomi C. Saido   +9 more
doaj   +1 more source

Somatic hypermutation of IGVH genes and aberrant somatic hypermutation in follicular lymphoma without BCL-2 gene rearrangement and expression

Haematologica, 2008
Background Follicular lymphoma is characterized by the t(14;18) translocation resulting in constitutive expression of BCL-2 protein; however approximately 10–15% of follicular lymphomas do not express BCL-2 protein, and a small fraction of these cases ...
Éva Gagyi, Zsófia Balogh, Csaba Bödör, Botond Timár, Lilla Reiniger, Linda Deák, Judit Csomor, Balázs Csernus, Ágota Szepesi, András Matolcsy   +9 more
doaj   +1 more source

Increasing fidelity and efficiency by modifying cytidine base-editing systems in rice

Crop Journal, 2020
The efficiency of plant cytidine base-editing systems is limited, and unwanted mutations frequently occur in transgenic plants. We increased the cytidine editing frequency and fidelity of the plant base editor 3 (BE3) and targeted activation-induced ...
Ruiying Qin, Shengxiang Liao, Juan Li, Hao Li, Xiaoshuang Liu, Jianbo Yang, Pengcheng Wei   +6 more
doaj   +1 more source

Activation-induced cytidine deaminase expression in colorectal cancer. [PDF]

Int J Clin Exp Pathol, 2019
Li L, Su N, Cui M, Li H, Zhang Q, Yu N, Wu S, Cao Z.   +7 more
europepmc   +2 more sources

Targeting mutagenesis in B cells: Phosphorylation goes beyond AID association

Molecular & Cellular Oncology, 2018
The mutations induced by activation-induced cytidine deaminase (AID) trigger antibody diversification but can cause genome instability. We find that AID phosphorylation is an important determinant of “off-target” mutagenesis and identify a drug that ...
Yunxiang Mu, Kevin M. McBride
doaj   +1 more source

Activation-Induced Cytidine Deaminase Expression in Gastric Cancer

Tumor Biology, 2007
Helicobacter pylori increases the risk of gastric cancer development and triggers aberrant expression of activation-induced cytidine deaminase (AID). The goal of the present study was to investigate whether AID expression is involved in the development or progression of gastric cancer and the nuclear expression of p53 protein in cancer cells.
Chang Jae, Kim, Jae Hwi, Song, Yong Gu, Cho, Zhang, Cao, Su Young, Kim, Suk Woo, Nam, Jung Young, Lee, Won Sang, Park   +7 more
openaire   +2 more sources

EXPRESSION OF AID-SPECIFIC mRNA IN PERIPHERAL BLOOD LYMPHOCYTES IN BRONCHIAL ASTHMA

Медицинская иммунология, 2015
The aim of this study was to evaluate a possible role of AID (AICDA – activation-induced (cytidine) deaminase) in the bronchial asthma (BA) pathogenesis. Materials and methods.
V. N. Mineev, M. A. Nyoma, L. N. Sorokina   +2 more
doaj   +1 more source