Results 41 to 50 of about 11,119 (186)

Helicobacter pylori-induced activation-induced cytidine deaminase expression and carcinogenesis [PDF]

Current Opinion in Immunology, 2010
Tumorigenesis is a multistep process in which the accumulation of genetic alterations drives the transformation of normal cells into malignant derivatives. Activation-induced cytidine deaminase (AID) contributes to immune system diversity by inducing somatic hypermutations and class-switch recombinations of human immunoglobulin genes.
Marusawa, Hiroyuki, Chiba, Tsutomu
openaire   +2 more sources

Induction of homologous recombination between sequence repeats by the activation induced cytidine deaminase (AID) protein

eLife, 2014
The activation induced cytidine deaminase (AID) protein is known to initiate somatic hypermutation, gene conversion or switch recombination by cytidine deamination within the immunoglobulin loci.
Jean-Marie Buerstedde, Noel Lowndes, David G Schatz   +2 more
doaj   +1 more source

Expression of activation‐induced cytidine deaminase decreases throughout the life [PDF]

Journal of Cellular and Molecular Medicine, 2003
AbstractActivation‐induced cytidine deaminase (AID) is an RNA editing enzyme, which contributes to generation of new functional genes from a restricted number of genes of plant and animal genome. This enzyme was involved in the process of somatic mutation and class switching in vertebrate.
D L, Radu, T, Kodera, C, Bona
openaire   +2 more sources

The off-target effects of AID in carcinogenesis

Frontiers in Immunology, 2023
Activation-induced cytidine deaminase (AID) plays a crucial role in promoting B cell diversification through somatic hypermutation (SHM) and class switch recombination (CSR).
Junna Jiao, Zhuangwei Lv, Yurong Wang, Liye Fan, Angang Yang, Angang Yang, Angang Yang   +6 more
doaj   +1 more source

Activation-Induced Cytidine Deaminase Does Not Impact Murine Meiotic Recombination [PDF]

G3 Genes|Genomes|Genetics, 2013
AbstractActivation-induced cytidine deaminase (AID) was first described as the triggering enzyme of the B-cell−specific reactions that edit the immunoglobulin genes, namely somatic hypermutation, gene conversion, and class switch recombination. Over the years, AID was also detected in cells other than lymphocytes, and it has been assigned additional ...
Cortesao, C. S., Freitas, R. F., Barreto, V. M.   +2 more
openaire   +3 more sources

Activation-induced cytidine deaminase mediates central tolerance in B cells [PDF]

Proceedings of the National Academy of Sciences, 2011
The Aicda gene product, activation-induced cytidine deaminase (AID), initiates somatic hypermutation, class-switch recombination, and gene conversion of Ig genes by the deamination of deoxycytidine, followed by error-prone mismatch- or base-excision DNA repair. These processes are crucial for
Masayuki, Kuraoka, T Matt, Holl, Dongmei, Liao, Mandy, Womble, Derek W, Cain, Alexander E, Reynolds, Garnett, Kelsoe   +6 more
openaire   +2 more sources

Repression of human activation induced cytidine deaminase by miR-93 and miR-155

BMC Cancer, 2011
Background Activation Induced cytidine Deaminase (AID) targets the immunoglobulin genes of activated B cells, where it converts cytidine to uracil to induce mutagenesis and recombination.
Holton Nathaniel W, Borchert Glen M, Larson Erik D   +2 more
doaj   +1 more source

Involvement of activation-induced cytidine deaminase in skin cancer development. [PDF]

J Clin Invest, 2016
Most skin cancers develop as the result of UV light-induced DNA damage; however, a substantial number of cases appear to occur independently of UV damage. A causal link between UV-independent skin cancers and chronic inflammation has been suspected, although the precise mechanism underlying this association is unclear.
Nonaka T, Toda Y, Hiai H, Uemura M, Nakamura M, Yamamoto N, Asato R, Hattori Y, Bessho K, Minato N, Kinoshita K.   +10 more
europepmc   +4 more sources

Complex regulation and function of activation-induced cytidine deaminase [PDF]

Trends in Immunology, 2011
Activation-induced cytidine deaminase (AID) instigates mutations and DNA breaks in Ig genes that undergo somatic hypermutation and class switch recombination during B cell activation in response to immunization and infection. This review discusses how AID expression and activity are regulated, including recent discoveries of AID-interacting proteins ...
openaire   +3 more sources

Evolution of Phosphorylation-Dependent Regulation of Activation-Induced Cytidine Deaminase [PDF]

Molecular Cell, 2008
Interaction of activation-induced cytidine deaminase (AID) with replication protein A (RPA) has been proposed to promote AID access to transcribed double-stranded (ds) DNA during immunoglobulin light chain and heavy chain class switch recombination (CSR).
Basu, Uttiya, Wang, Yabin, Alt, Frederick W.   +2 more
openaire   +2 more sources