Results 71 to 80 of about 11,119 (186)

DNA Methylation Dynamics of Germinal Center B Cells Are Mediated by AID

Cell Reports, 2015
Changes in DNA methylation are required for the formation of germinal centers (GCs), but the mechanisms of such changes are poorly understood. Activation-induced cytidine deaminase (AID) has been recently implicated in DNA demethylation through its ...
Pilar M. Dominguez, Matt Teater, Nyasha Chambwe, Matthias Kormaksson, David Redmond, Jennifer Ishii, Bao Vuong, Jayanta Chaudhuri, Ari Melnick, Aparna Vasanthakumar, Lucy A. Godley, F. Nina Papavasiliou, Olivier Elemento, Rita Shaknovich   +13 more
doaj   +1 more source

Response to 'Domain organization of activation-induced cytidine deaminase' [PDF]

Nature Immunology, 2003
Although we have not done any structural studies, we agree that elucidation of the structure of AID is essential for understanding the function of AID. Zaim and Kierzek suggest yeast CD as a template for AID structure prediction by using 3DJury, a newly developed software package.
Van-Thanh Ta, Tasuku Honjo
openaire   +1 more source

Plant organelle C‐to‐U RNA editing factors can operate successfully in yeast (Saccharomyces cerevisiae) as an easily amenable eukaryotic system for their functional analysis

The FEBS Journal, EarlyView.
Plant‐type pentatricopeptide repeat proteins capable of C‐to‐U RNA editing perform faithfully when expressed in a new heterologous system, the yeast Saccharomyces cerevisiae. They were tested with constitutive and inducible expression and with a set of different solubility tags. PPR56, PPR65, and PPR78 from P.
Shyam Ramanathan, Annika Hanraths, Jingchan Xie, Mareike Schallenberg‐Rüdinger, Volker Knoop   +4 more
wiley   +1 more source

Molecular Analysis of Activation-Induced Cytidine Deaminase Gene in Immunoglobulin-E Deficient Patients

Clinical and Developmental Immunology, 2008
Understanding how class switch recombination (CSR) is regulated to produce immunoglobulin E (IgE) has become fundamental because of the dramatic increase in the prevalence of IgE-mediated hypersensitivity reactions.
Sergio Roa, Maria Isidoro-Garcia, Ignacio Davila, Elena Laffond, Felix Lorente, Rogelio Gonzalez-Sarmiento   +5 more
doaj   +1 more source

Diversity in the Cow Ultralong CDR H3 Antibody Repertoire

Frontiers in Immunology, 2018
Typical antibodies found in humans and mice usually have short CDR H3s and generally flat binding surfaces. However, cows possess a subset of antibodies with ultralong CDR H3s that can range up to 70 amino acids and form a unique “stalk and knob ...
Jeremy K. Haakenson, Ruiqi Huang, Vaughn V. Smider   +2 more
doaj   +1 more source

Natural Variation of a PPR Coding Gene SST1 Confers Salt Tolerance During Soybean Domestication

Plant Biotechnology Journal, EarlyView.
ABSTRACT Soil salinity is one of the constraints that adversely affect seedling growth and limit soybean yield. Identifying salt tolerance genes and profiling their allele variants are crucial for elucidating the mechanisms underlying salt tolerance in soybean and enabling the genetic improvement of salt‐tolerant cultivars.
Hui Wang, Huifang Yuan, Yadi Wang, Weikang Xi, Xiaodi Wang, Ruiheng Tang, Qi Xu, Jiaying Li, Dongxu Liu, Qingyong Yang, Xutong Wang, Fanjiang Kong, Baohui Liu, Xia Li, Zhijuan Wang   +14 more
wiley   +1 more source

Enhancers Improve the AID-Induced Hypermutation in Episomal Vector for Antibody Affinity Maturation in Mammalian Cell Display

Antibodies, 2018
The induction of somatic hypermutation (SHM) in various cell lines by activation-induced cytidine deaminase (AID) has been used in protein-directed selection, especially in antibody affinity maturation.
Chuan Chen, Jie Wang, Yun Zhao, Shaopeng Chen, Zhishang Hu, Long Chen, Haiying Hang   +6 more
doaj   +1 more source

Artificial Mutations in the Nuclear Gene Encoding Mitochondrial RNA Polymerase Restore Pollen Fertility in Cytoplasmic Male Sterile Tomato

Plant Biotechnology Journal, EarlyView.
ABSTRACT Cytoplasmic male sterility (CMS) and restorer of fertility (Rf) are important traits in F1 hybrid breeding. However, the CMS/Rf system has not been used in tomatoes because of the limited resources of Rf lines. In this study, we performed mutagenesis in tomato CMS seeds and successfully obtained 13 suppressor mutants with pollen fertility ...
Kosuke Kuwabara, Rika Nakajima, Van Bosstraeten Alexis Gaetan, Kentaro Ezura, Kinya Toriyama, Tohru Ariizumi, Kenta Shirasawa   +6 more
wiley   +1 more source

Fate mapping for activation-induced cytidine deaminase (AID) marks non-lymphoid cells during mouse development. [PDF]

PLoS ONE, 2013
The Aicda gene encodes Activation-Induced cytidine Deaminase (AID), an enzyme essential for remodeling antibody genes in mature B lymphocytes. AID is also responsible for DNA damage at oncogenes, leading to their mutation and cancer-associated chromosome
Philipp C Rommel, David Bosque, Alexander D Gitlin, Gist F Croft, Nathaniel Heintz, Rafael Casellas, Michel C Nussenzweig, Skirmantas Kriaucionis, Davide F Robbiani   +8 more
doaj   +1 more source

Interplay between RNA‐protein interactions and RNA structures in gene regulation

FEBS Open Bio, Volume 16, Issue 2, Page 299-313, February 2026.
Methodological advances in mapping transcriptome‐wide RNA‐protein interactions and RNA structures have started to uncover the potential of RNP conformations in gene regulation. Competing RNA–RNA, RNA‐protein and protein–protein interactions shape the compaction and function of RNPs throughout their lifetime and may provide novel therapeutic targets in ...
Jenni Rapakko, Mauro Scaravilli, Minna‐Liisa Änkö   +2 more
wiley   +1 more source